Pellagra: A clue as to why energy failure causes diseases?

Abstract:

:Pellagra is a curable dietary illness that unchecked leads to dementia, diarrhoea, dermatitis and death due to lack of the precursors for NAD(H). In addition it caused a wide range of monosyndromic degenerative and functional neurological disorders as well as profound developmental, premature aging and metabolic syndromes. Pellagrins harbour many chronic infections including tuberculosis, yeasts and malaria, that may be symbionts supplying nicotinamide adenine dinucleotide {NAD(H)} when the diet is poor. Many common diseases and aging may be caused by electrogenic energy mismatches from lack of a timely supply of NAD(H) creating disturbed metabolic fields and "protonopathies". Initially these may present in compartments fronted by homeostatic corrections from chronic symbiotic infections to inflammatory disease, cancer and degenerative/autophagic diseases that can all release NAD(H).

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Williams AC,Ramsden DB

doi

10.1016/j.mehy.2007.01.029

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

618-28

issue

3

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(07)00073-4

journal_volume

69

pub_type

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