Contribution to problems of pseudohypoaldosteronism type I in children.

abstract：:It has been shown by Elmets et al. (1) that ultraviolet irradiation of the skin followed by the application of a normally sensitizing antigen results in tolerance induction to the antigen. This tolerance is due to the induction of suppressor T-cells specific for the antigen. Multiple sclerosis is more common in certai...

journal_title：Medical hypotheses

authors： Sharpe RJ

更新日期：1986-04-01 00:00:00

abstract：:For a number of years, the principal attention was accorded total serum cholesterol as a possible predictor of cardiovascular pathosis. More recently, emphasis has been shifted to the high-density lipoproteins (HDL). Now consideration is turning to the ratio of total serum cholesterol to high-density lipoproteins. In ...

journal_title：Medical hypotheses

authors： McDonagh EW,Rudolph CJ,Cheraskin E

更新日期：1982-12-01 00:00:00

abstract：:The new prion diseases that have emerged in the last 15 years are bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (variant CJD). Although initially confined to the UK, these diseases have recently emerged in other European countries. The accepted cause of the human disease is that BSE spre...

journal_title：Medical hypotheses

authors： Brown DR

更新日期：2001-11-01 00:00:00

abstract：:Evidence is reviewed supporting a hypothesis of an anticarcinogenic effect of magnesium. Animal studies reported increased cancer in rodents maintained on magnesium deficient diets and a preventive effect for rodents fed excess levels of magnesium. Epidemiologic evidence is presented that magnesium levels in water, fo...

journal_title：Medical hypotheses

authors： Blondell JM

更新日期：1980-08-01 00:00:00

abstract：:Skin photoaging, the most common skin damage, is caused by chronic UV irradiation. It is involved in the reduction, aging and apoptosis of fibroblasts (FBs) as well as the blockage of transforming growth factor-beta (TGF-β)/Smad and p38 mitogen-actived protein kinase (MAPK) signaling pathways. Dermal multipotent stem ...

journal_title：Medical hypotheses

authors： Zhong J,Hu N,Xiong X,Lei Q,Li L

更新日期：2011-03-01 00:00:00

abstract：:The hypterphosphorylation of tau proteins is a well-established step in the expression of the pathological features in Alzheimer's disease (AD). While a primary event that links aluminum and AD, the so-called 'aluminum hypotheses', is far from being demonstrated, however, the metal ion could be an important etiologica...

journal_title：Medical hypotheses

authors： Zatta PF

更新日期：1995-03-01 00:00:00

abstract：:It is suggested that chronic fatigue syndrome/fibromyalgia is caused by virus injury to the calcium channels leading to larger quantities than usual of calcium ions entering the striated muscle cells. Should this be true, then treatment with a calcium antagonist (CA) may possibly be of value. ...

journal_title：Medical hypotheses

authors： Lund-Olesen LH,Lund-Olesen K

更新日期：1994-07-01 00:00:00

abstract：:At present, researchers are still debating the effect of blue light on the eyes.Studies have shown thatwhile blue lighthelpsto maintain normal biological rhythms,excessive blue light radiation mayinduce fundus lesions. The preliminary survey shows that the incidence of vitreous floaters is high among digital device us...

journal_title：Medical hypotheses

authors： Chen JT,Wu HJ

更新日期：2020-06-01 00:00:00

abstract：:A novel virus named 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) causes symptoms that are classified as coronavirus disease (COVID-19). Respiratory conditions are extensively described among more serious cases of COVID-19, and the onset of acute respiratory distress syndrome (ARDS) is one of the hallmark features of ...

journal_title：Medical hypotheses

authors： Geier MR,Geier DA

更新日期：2020-07-01 00:00:00

abstract：:Intrinsic radio-sensitivity is the determinant of differential response of tumours to low LET ionising radiations. The probabilistic DNA fibril both model shows intrinsic radio-sensitivity factor [I] as function of nuclear diameter (Nd) and intra cellular hydrogen ion concentration [H+]. Linking probabilities of letha...

journal_title：Medical hypotheses

authors： Mohammed SA

更新日期：2013-12-01 00:00:00

abstract：:Numerous medical conditions present with acute and severe autonomic and muscular overactivity. These syndromes include Neuroleptic Malignant Syndrome, Serotonin Syndrome, Dysautonomia (or paroxysmal sympathetic storms) following acquired brain injury, Autonomic Dysreflexia, Parkinsonian-Hyperpyrexia Syndrome, Malignan...

journal_title：Medical hypotheses

authors： Baguley IJ

更新日期：2008-01-01 00:00:00

abstract：:It is proposed that there is biological regulation of the low molecular weight antioxidant (LMWA) status of the body, and that these different antioxidants work in concert and in homeostasis as a system analogous to the regulation of acid-base status (pH). The theoretical design characteristics for such a system inclu...

journal_title：Medical hypotheses

authors： Berry EM,Kohen R

更新日期：1999-11-01 00:00:00

abstract：:Chlorination of potable water supplies high in organics may yield carcinogenic compounds such as trihalomethanes. Chlorine dioxide has been proposed as an alternative disinfectant to chlorine. However, chlorine dioxide is a strong oxidant that forms significant amounts of chlorite when added to potable water supplies,...

journal_title：Medical hypotheses

authors： Moore GS,Calabrese EJ,DiNardi SR,Tuthill RW

更新日期：1978-09-01 00:00:00

abstract：:Organisms release their antigens into the environment. Some antigens are volatile and may pass into the blood of other organisms during respiration. Fetal antigens enter the mother's bloodstream through the placenta. Foreign antigens in the blood can cause various chemical changes and may initiate an immune reaction. ...

journal_title：Medical hypotheses

authors： Rumyantsev SN,Grzeszczuk J

更新日期：1995-07-01 00:00:00

abstract：:Immunotherapy has attracted attention as a novel treatment modality for malignant melanoma. Although the use of immunotherapy in metastatic melanoma has shown promising results, there remains a lack of predictive biomarkers indicating treatment benefit from immunotherapy. There is growing evidence suggesting that micr...

journal_title：Medical hypotheses

authors： Kubecek O,Trojanova P,Molnarova V,Kopecky J

更新日期：2016-08-01 00:00:00

abstract：:Endophthalmitis following pars-plana procedures such as a vitrectomy vitreo-retinal procedures has been infrequently reported in literature. The cited incidence is about 0.1% to 0.2%. In the 8 cases of endophthalmitis that have been reported in literature, the prognosis has been indicated as very poor due to a delay i...

journal_title：Medical hypotheses

authors： Venkatesh P,Verma L,Tewari H

更新日期：2002-06-01 00:00:00

abstract：:Many clinical trials have clearly demonstrated the benefit of statins in the prevention of coronary heart disease. Although other effects have subsequently been described, the so-called pleiotropic effects of statins, there is a tendency to relate all those effects, more or less directly, to inhibition of 3-hydroxy-3-...

journal_title：Medical hypotheses

authors： Negrão MR,Mota A,Azevedo I,Martins MJ

更新日期：2006-01-01 00:00:00

abstract：:Increased chemotactic activity of peripheral polymorphonuclear (PMN) cells has been described in disease states of different etiology and may represent a common pathway in the generation of an inflammatory reaction. The suppressive effect of colchicine on PMN chemotaxis may explain its effect in apparently unrelated d...

journal_title：Medical hypotheses

authors： Levy M,Ehrenfeld M,Gallily R,Eliakim M

更新日期：1981-01-01 00:00:00

abstract：:The results described in this paper partially agree with the hypothesis that mesenteric lymph nodes (MLN) of depleted growing rats recover their antigen specific determinants after the oral administration of 20% casein for 5-9 days following the time course of antigen dependent changes observed in virgin lymph nodes. ...

journal_title：Medical hypotheses

authors： Langini SH,López MC,Slobodianik NH,Sanahuja JC,Rio ME,Roux ME

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:There is widespread loss of acetylcholine and other neurotransmitters in Alzheimer's disease and vascular dementia. It has generally been assumed that death of neurons causes neurotransmitter loss, but alternatively neurotransmitter depletion itself may at least contribute to neurodegeneration. PRESENTATION...

journal_title：Medical hypotheses

authors： Alisky JM

更新日期：2006-01-01 00:00:00

abstract：:The incidence and prevalence of Crohn's disease (CD) among children in developed countries is extremely high. Although, dietary factors have long been implicated, to date no single causative element has been identified. Risks or benefits for CD from dietary elements would depend on their appropriate metabolism within ...

journal_title：Medical hypotheses

authors： K Amre D,G Seidman E

更新日期：2003-03-01 00:00:00

abstract：:Clinical studies have shown that ionic zinc (Zn2+) dissolved in the mouth shortened manifestations of the common cold significantly, by an unknown mechanism. The observed immediate effect on symptoms is consonant with osmotic transport of Zn2+, placing a temporary chemical clamp on critical nerves. It is proposed that...

journal_title：Medical hypotheses

authors： Novick SG,Godfrey JC,Godfrey NJ,Wilder HR

更新日期：1996-03-01 00:00:00

abstract：:We would like to put forward the hypothesis that cancer patients may produce autoantibodies that promote uncontrolled cell growth and thereby function as oncogenes. Dying cells release proteins that stimulate the production of autoantibodies, an event also known to occur during the earliest stages of tumor growth. If ...

journal_title：Medical hypotheses

authors： Admon A,Shoshan SH

更新日期：2006-01-01 00:00:00

abstract：:The possibility of a pathway, common to progression, in entities in which activated macrophages or microglia are present, amenable to particular therapies, is discussed. Immunoglobulin synthesis and activation of the complement pathway may be critical elements in progression. It is possible progression in a proportion...

journal_title：Medical hypotheses

authors： Milder DG

更新日期：2006-01-01 00:00:00

abstract：:An unacceptably high incidence of preterm labour is seen in the black and coloured communities of South Africa. This hypothesis proposes that sodium-potassium adenosine triphosphatase activity plays an important role in preterm labour. The impaired activity of the sodium pump leads to increased cytosolic calcium level...

journal_title：Medical hypotheses

authors： Du Toit PJ,Theron JJ,Grobler AS,Steinmann CM,Van Papendorp DH

更新日期：1996-09-01 00:00:00

abstract：:In this work a new theory of acoustic signal detection in the inner ear and an experimental explanation of the causes of bifilar cochlear structure was presented. Our innovative approach describes sound detection in a completely different way from the one currently adopted. It requires analyzing the inner ear system i...

journal_title：Medical hypotheses

authors： Dora J,Wojcieszak D,Kaczmarek D,Mazur M,Aksenczuk A

更新日期：2020-02-18 00:00:00

abstract：:The function of the gallbladder is questioned in a hypothesis postulating that all bile which enters this reservoir is totally absorbed to the liver and none of it flows back to the cystic duct and duodenum. Cholecystokinesis is believed to increase and maintain a gradient of intravesical pressure which increases the ...

journal_title：Medical hypotheses

authors： Al-Hilli F

更新日期：1986-10-01 00:00:00

abstract：:We describe here a new technique for analyzing human growth curves using a first order kinetic representation. Plotting in ([h infinity-ht)/h infinity] vs time (where h infinity and ht represent the final and instantaneous heights) transforms growth curves into 3 linear phases and 2 interphases. These growth parameter...

journal_title：Medical hypotheses

authors： Schreiber G,Baron B

更新日期：1985-02-01 00:00:00

abstract：:Exocytosis and endocytosis are the way of macromolecules transmembrane transport. Pulmonary surfactant (PS), one of such macromolecules, is secreted via exocytosis of lamellar bodies and recycled via endocytosis by type II alveolar epithelial cells (AEC II). It maintains low alveolar surface tension and is therefore e...

journal_title：Medical hypotheses

authors： Xu C,Liu W,Wang Y,Chen Z,Ji Y

更新日期：2009-02-01 00:00:00

abstract：:Elevated levels of aluminium (Al), strontium (Sr), barium (Ba), iron (Fe), manganese (Mn) cations - combined with deficiencies of magnesium (Mg)/calcium (Ca) - have been observed in the foodchains that traditionally support the Chamorro populations affected by high incidence clusters of Alzheimer (AD), Parkinson-like ...

journal_title：Medical hypotheses

authors： Purdey M

更新日期：2004-01-01 00:00:00