Fetal death repetition: the event memory hypothesis.

abstract：:Periodontal disease is a chronic multifactorial infectious and inflammatory disease associated with several chronic systemic diseases, such as diabetes, cardiovascular diseases (CVD), chronic obstructive pulmonary disease, hypertension, Alzheimer's disease and so on. These same systemic diseases have been associated w...

journal_title：Medical hypotheses

authors： Räisänen IT,Umeizudike KA,Pärnänen P,Heikkilä P,Tervahartiala T,Nwhator SO,Grigoriadis A,Sakellari D,Sorsa T

更新日期：2020-11-01 00:00:00

abstract：:The recent unprecedented increase of childhood obesity has led to an alarming rise in type 2 diabetes mellitus (T2D) among these children. The process underlying the progression from simple obesity to T2D is not well understood. Cortisol is a candidate factor in the pathogenesis of T2D, as it can exacerbate insulin re...

journal_title：Medical hypotheses

authors： Soros A,Zadik Z,Chalew S

更新日期：2008-09-01 00:00:00

abstract：:This hypothesis agrees with Le Vay's suggestion that the two phenomena of childhood behavior and adult sexuality are induced by separate events rather than being two events in a single chain. However, it differs from Le Vay in that it includes the postnatal period, as being of crucial importance in the development of ...

journal_title：Medical hypotheses

authors： Roper WG

更新日期：1996-02-01 00:00:00

abstract：:Yawning continues to pose as a scientist's conundrum. Evidence is presented of yawning and contagious yawning in a number of different neurological disorders. Explanations are discussed in the context of disparate neurological disorders together with proposals for how theses findings may be linked. Thus, greater under...

journal_title：Medical hypotheses

authors： Thompson SB

更新日期：2010-12-01 00:00:00

abstract：:p27(Kip1) (here after referred to as p27) is a member of a family of cyclin-dependent kinase inhibitors that control cell cycle. There is a considerable evidence that p27 plays a pivotal role in multiple foundational cellular processes, including cell proliferation, cell differentiation, and apoptosis. A large number ...

journal_title：Medical hypotheses

authors： Guan X,Chen L,Wang J

更新日期：2007-01-01 00:00:00

abstract：:Currently, drug repurposing is an alternative to novel drug development for the treatment of COVID-19 patients. The antimalarial drug chloroquine (CQ) and its metabolite hydroxychloroquine (HCQ) are currently being tested in several clinical studies as potential candidates to limit SARS-CoV-2-mediated morbidity and mo...

journal_title：Medical hypotheses

authors： Derwand R,Scholz M

更新日期：2020-09-01 00:00:00

abstract：UNLABELLED:T helper (Th) lymphocytes have been classified into distinct subsets, Th1 and Th2 on the basis of the cytokines they produce. According to the cross-regulatory properties of Th1 and Th2 cells, one would assume that to be affected by a Th1 type disease increases susceptibility to a Th1 type disease and inhibi...

journal_title：Medical hypotheses

authors： Shahabi S,Hassan ZM,Jazani NH,Ebtekar M

更新日期：2006-01-01 00:00:00

abstract：:Treatment-resistant schizophrenia (TRS) is one of the subgroups of schizophrenia of which little is known with regard to its optimal mechanism. Treatment response, either as full remission of symptoms or prediction by biomarker, is important in psychiatry. We have proposed a model that integrates dopaminergic and glut...

journal_title：Medical hypotheses

authors： Huang LC,Lin SH,Tseng HH,Chen KC,Yang YK

更新日期：2020-10-01 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a lethal muscle wasting disease caused by a lack of dystrophin, which eventually leads to apoptosis of muscle cells and impaired muscle contractility. Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated protein 9 (CRISPR/Cas9) gene editing of induced pluripo...

journal_title：Medical hypotheses

authors： Hagan M,Ashraf M,Kim IM,Weintraub NL,Tang Y

更新日期：2018-01-01 00:00:00

abstract：:Metastasis is the leading cause of cancer death, yet it is mechanistically considered a very inefficient process suggesting the presence of some sort of (e.g. systemic) routes for fuelling the process. The pre-metastatic niche formation is described as one such metastasis promoting route. Now, the emerging potentials ...

journal_title：Medical hypotheses

authors： Ghasemi R,Grassadonia A,Tinari N,Piccolo E,Natoli C,Tomao F,Iacobelli S

更新日期：2013-01-01 00:00:00

abstract：:The precise role of erythrophagocytosis in sickle cell disease is not known. Using hematological data from three studies and 791 subjects comprising of eight epidemiological groups, we found a strong statistical support for the hypothesis that erythrophagocytosis is increased in sickle cell trait, that neutrophils and...

journal_title：Medical hypotheses

authors： Mamtani M,Sharma M,Amin M,Amin A,Jawahirani A,Kulkarni H

更新日期：2007-01-01 00:00:00

abstract：:Neurodegenerative diseases are associated with neuronal inclusions, comprised of protein aggregates. In Alzheimer's Disease (AD) and Lewy Body Disease (LBD) such lesions are distributed in a hierarchical retrograde transynaptic spatial pattern. This implies a retrograde transynaptic temporal propagation as well. There...

journal_title：Medical hypotheses

authors： Royall DR

更新日期：2013-02-01 00:00:00

abstract：:Injury and organ failure after irradiation of late-responding tissues is a substantial problem in radiation oncology and a major threat after accidental or belligerent exposures. The mechanisms of injury may include death of clonogens, vascular injury, activation of cytokine networks, and/or chronic oxidative stress. ...

journal_title：Medical hypotheses

authors： Cohen SR,Cohen EP

更新日期：2013-02-01 00:00:00

abstract：:Excessive milk consumption may adversely affect the circulation on account of the high calcium content of milk and because lactose promotes the intestinal absorption of calcium. Excessive calcium intake may cause calcification and rigidification of the large elastic arteries, which could be an important factor in caus...

journal_title：Medical hypotheses

authors： Seely S

更新日期：2000-05-01 00:00:00

abstract：:The three events, viz. schizophrenia, dissociative anaesthesia and Near-Death Experience, despite their seemingly unrelated manifestation to each other, have nevertheless similar functional basis. All three events are linked to the glutamate sensitive N-methyl-D-aspartate (NMDA) receptor complex, which serves as their...

journal_title：Medical hypotheses

authors： Bonta IL

更新日期：2004-01-01 00:00:00

abstract：:Keratoacanthomas have many characteristics of squamous cell carcinoma and in the past were interpreted as squamous cell carcinomas. It is now known that these lesions spontaneously resolve if left untreated. In man the lesions occur on sunlight damaged areas or areas exposed to tar. Many of the experimental cancers of...

journal_title：Medical hypotheses

authors： Stone OJ

更新日期：1988-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most frequent cause of dementia. Besides cognitive deterioration, patients with AD are prone to seizures - more than 20% of patients diagnosed with AD experience at least one unprovoked seizure and up to 7% have recurrent seizures. Although available antiepileptic drugs (AEDs) may suppr...

journal_title：Medical hypotheses

authors： Damar U,Gersner R,Johnstone JT,Schachter S,Rotenberg A

更新日期：2017-02-01 00:00:00

abstract：:It is proposed that, in addition to genetic factors involved in immune attack on myelin, higher concentrations of nerve growth factor in certain tissues during development determine susceptibility to multiple sclerosis. High early nerve growth factor in some vasculature of spontaneously hypertensive rats increases sym...

journal_title：Medical hypotheses

authors： Olson RC

更新日期：1998-12-01 00:00:00

abstract：:Multiple sclerosis remains a rare neurological disease of unknown aetiology, with a unique distribution, both geographically and historically. Rare in equatorial regions, it becomes increasingly common in higher latitudes; historically, it was first clinically recognized in the early nineteenth century. A hypothesis, ...

journal_title：Medical hypotheses

authors： Carlyle IP

更新日期：1997-12-01 00:00:00

abstract：:Alpha-fetoprotein (AFP) is overexpressed in the majority of hepatocellular carcinomas (HCCs), and thus may offer attractive target for immunotherapy against this neoplasm. CD40 ligand (CD40L) is the major signal that induces B cells to efficiently present antigen to T cells, and CD40-activated B (CD40-B) lymphocyte ce...

journal_title：Medical hypotheses

authors： Wan Y,Ma X,Li X,Yi J

更新日期：2009-11-01 00:00:00

abstract：:Preeclampsia (PE) and gestational diabetes mellitus (GDM) are two of the most common medical complications of pregnancy, with risks for both mother and child. Like many other antepartum complications, PE and GDM occur only in pregnancy. However, it is not clear if pregnancy itself is the cause of these complications o...

journal_title：Medical hypotheses

authors： Wen SW,Xie RH,Tan H,Walker MC,Smith GN,Retnakaran R

更新日期：2012-07-01 00:00:00

abstract：:The mechanism of pathogenesis of idiopathic Parkinson's disease (PD) is unknown. In a study of 200 PD patients and 200 age- and sex-matched controls, Strang noted a marked and statistically significant higher incidence of ulcers (diagnosed by X-ray or surgery) in the PD patients compared to the controls (14% to 4%). T...

journal_title：Medical hypotheses

authors： Altschuler E

更新日期：1999-07-01 00:00:00

abstract：:In the recent hypothesis that hair loss might be a manifestation of metabolic abnormalities particularly hyperglicemia. It has been reported various environmental risk factors affecting hair loss. There is growing evidence on the relationship between prediabetes and worse metabolic profile. However, there are few stud...

journal_title：Medical hypotheses

authors： Cakir E

更新日期：2012-12-01 00:00:00

abstract：:Accurate detection and prevention of overuse musculoskeletal injuries is limited by the nature of somatic tissue injury. In the pathogenesis of overuse injuries, it is well recognized that an abnormal inflammatory response occurs within somatic tissue before pain is perceived which can disrupt the normal remodeling pr...

journal_title：Medical hypotheses

authors： Gisselman AS,Baxter GD,Wright A,Hegedus E,Tumilty S

更新日期：2016-02-01 00:00:00

abstract：:The rigid gas permeable contact lens (RGPCL) is an ideal choice to improve the corrective vision of patients with a high degree of refractive error, keratoconus and corneal transplantation. However, RGPCL fitting is not an easy work for those patients with extremely irregular corneal surface. Technicians or doctors of...

journal_title：Medical hypotheses

authors： Zhao F,Zhao G,Weijie F,Chen L

更新日期：2018-04-01 00:00:00

abstract：:Vitamin A is a fat-soluble vitamin required for many physiological functions. The intracellular transport of vitamin A is assisted by proteins called cellular retinol-binding proteins (CRBP I/II). The absorption, storage and usage of vitamin A are regulated by a protein called lecithin:retinol acyltransferase (LRAT), ...

journal_title：Medical hypotheses

authors： Mezaki Y,Fujimi TJ,Senoo H,Matsuura T

更新日期：2016-03-01 00:00:00

abstract：:Seizure (ictal) behavior in humans has been observed and recorded since ancient times. A satisfactory solution to this vexing problem continues to elude medical science. Antiepileptic drug (AED) therapy fails to control seizures in 20% of patients with primary generalized epilepsy and 35% of patients with partial epil...

journal_title：Medical hypotheses

authors： Doman G,Pelligra R

更新日期：2003-01-01 00:00:00

abstract：:Fibromyalgia syndrome (FMS) is a chronic widespread pain syndrome that is estimated to affect 4-8 million US adults. The exact molecular mechanisms underlying this illness remain unclear, rendering most clinical treatment and management techniques relatively ineffective. It is now known that abnormalities in both noci...

journal_title：Medical hypotheses

authors： Recla JM,Sarantopoulos CD

更新日期：2009-08-01 00:00:00

abstract：:Although many risk factors influence atherogenesis, LDL appears to play a primary role in this process. In prospective epidemiology, coronary risk increases as LDL cholesterol increases, throughout the entire range of concentrations encountered in healthy humans. Coronary risk is minimal in individuals and populations...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2005-01-01 00:00:00

abstract：:It is well documented that depressed patients, as a result of their illness, often experience some difficulties with their memory. This hypothesis suggests a vice-versa; that it is a gradual impairment and ultimate failure of specific memory systems that may underpin the onset and continuation of a depressive illness....

journal_title：Medical hypotheses

authors： Frais AT

更新日期：2007-01-01 00:00:00