Abstract：
:Treatment-resistant schizophrenia (TRS) is one of the subgroups of schizophrenia of which little is known with regard to its optimal mechanism. Treatment response, either as full remission of symptoms or prediction by biomarker, is important in psychiatry. We have proposed a model that integrates dopaminergic and glutamatergic systems with the biological interactions of TRS patients. We hypothesize that the subgroups of schizophrenia may be determined by glutamatergic and dopaminergic concentrations prior to medical treatment. This hypothesis implies that higher glutamatergic concentration in the brain with normalized or decreased dopamine synthesis capacity may explain aspects of TRS as observed in clinical medical practice, neuroimaging measurements, and brain stimulations. According to this hypothesis, the ability to prescribe a proper medication combination, to predict the outcome in first-episode psychosis, and personalized medicine for chronic schizophrenia patients can be applied into practice. This represents an initial step in explaining psychosis due to the valence of two neurotransmitters. Future studies are needed to examine the validity of this mechanism.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Huang LC,Lin SH,Tseng HH,Chen KC,Yang YKdoi
10.1016/j.mehy.2020.110159subject
Has Abstractpub_date
2020-10-01 00:00:00pages
110159eissn
0306-9877issn
1532-2777pii
S0306-9877(20)31195-6journal_volume
143pub_type
杂志文章abstract：:Multiple sclerosis remains a rare neurological disease of unknown aetiology, with a unique distribution, both geographically and historically. Rare in equatorial regions, it becomes increasingly common in higher latitudes; historically, it was first clinically recognized in the early nineteenth century. A hypothesis, ...
journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
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abstract：:Hepatic encephalopathy (HE) is a common neuropsychiatric complication of liver disease affecting about 20-30% patients with cirrhosis. HE may only affect quality of life (e.g. impairments in attention; coordination; driving ability), but in some patients this progresses to coma and death; defining mortality in those w...
journal_title：Medical hypotheses
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journal_title：Medical hypotheses
pub_type： 杂志文章,评审
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
pub_type： 杂志文章,评审
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doi：10.1016/j.mehy.2018.02.028
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pub_type： 杂志文章
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更新日期：2017-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：1991-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：1995-06-01 00:00:00
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更新日期：2019-09-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2001-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1993-02-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.07.030
更新日期：2006-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
