Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: X. Correlation of the induceability of hepatomas and alpha-fetoprotein gene activity.

abstract：BACKGROUND:Geldanamycin, which is one of the most potent and effective hsp90 alpha inhibitor until date, is normally used to target breast cancer. Inhibition of hsp90 alpha leads to the degradation of client proteins involved in the initiation and progress of breast cancer pathogenesis. Hence, Geldanamycin has been wid...

journal_title：Medical hypotheses

authors： Mahanta S,Pilla S,Paul S

更新日期：2013-09-01 00:00:00

abstract：:The science of osteoimmunology, a relatively new field of research, reveals the important interactions between the immune system and skeletal system. Interactions occur between prostaglandin metabolism, inflammatory proteins and bone metabolism. Systemic as well as local sources of inflammation appear to be actively i...

journal_title：Medical hypotheses

authors： van Esch RW,Kool MM,van As S

更新日期：2013-08-01 00:00:00

abstract：:Limbic associated pelvic pain is a proposed pathophysiology designed to explain features commonly encountered in patients with chronic pelvic pain, including the presence of multiple pain diagnoses, the frequency of previous abuse, the minimal or discordant pathologic changes of the involved organs, the paradoxical ef...

journal_title：Medical hypotheses

authors： Fenton BW

更新日期：2007-01-01 00:00:00

abstract：:We describe a six-month-old girl with microcephaly, developmental delay, truncal hypotonia, left pyramidal signs, partial seizures and myoclonic spasms, born to a feverish mother. MRI showed bilateral vascular lesions in the territory of the middle cerebral arteries, prevalent in the right hemisphere, together with hy...

journal_title：Medical hypotheses

authors： Spalice A,Del Balzo F,Papetti L,Nicita F,Ursitti F,Salvatori G,Iannetti P

更新日期：2011-08-01 00:00:00

abstract：:Complex Regional Pain Syndrome (CRPS) has defied a clear unified pathological explanation to date. Not surprisingly, treatments for the condition are limited in number, efficacy and their ability to enact a cure. Whilst many observations have been made of physiological abnormalities, how these explain the condition an...

journal_title：Medical hypotheses

authors： Russo M,Georgius P,Santarelli DM

更新日期：2018-10-01 00:00:00

abstract：:Medical Hypotheses exists to give ideas and speculations in medicine a fair hearing. Doing this is not easy. Most conventional journals would regard some of what is published here as questionable, most referees would reject it as 'unproven'. We have more liberal standards, for reasons we have presented before. But we ...

journal_title：Medical hypotheses

authors： Bains W

更新日期：2005-01-01 00:00:00

abstract：:The secretion of Follicle Stimulating Hormone by the pituitary gland is not regulated entirely by the negative feedback from gonadal steroids. There is ample evidence that the secretion of FSH is regulated by a non-steroidal hormone of gonadal origin termed "inhibin". Using a radioimmunoassay procedure, immunoreactive...

journal_title：Medical hypotheses

authors： Sheth AR,Vanage GR,Hurkadli KS,Sheth NA

更新日期：1984-10-01 00:00:00

abstract：:A large number of epileptic patients suffer from refractory epilepsy, despite optimal treatment; thus these patients require new therapeutic approaches. Focal seizure activity is typically initiated in a fixed and localized region, which subsequently spreads to neighboring regions or more distant areas. At the initial...

journal_title：Medical hypotheses

authors： Zhang L,Liang S,Zhang G,Kang X

更新日期：2013-11-01 00:00:00

abstract：:NETosis, being an alternative form of cell death is the creation of web-like chromatin decondensates by suitably primed neutrophils as a response to stimulus aimed at containing and eliminating the same. In certain situations, it causes more harm than benefit in the form of bystander damage directly or via activation ...

journal_title：Medical hypotheses

authors： Gupta S,Sahni V

更新日期：2020-11-01 00:00:00

abstract：:Currently, several prominent researchers are investigating the role of reactive oxygen and free radicals in the activation of latent HIV in infected individuals. Early clinical applications of free radical scavengers and plant-based antioxidant systems have shown promise of efficacy in altering this process. This manu...

journal_title：Medical hypotheses

authors： Greenspan HC

更新日期：1993-02-01 00:00:00

abstract：:(1) Background: RNA viruses and especially coronaviruses could act inside host cells not only by building their own proteins, but also by perturbing the cell metabolism. We show the possibility of miRNA-like inhibitions by the SARS-CoV-2 concerning for example the hemoglobin and type I interferons syntheses, hence hig...

journal_title：Medical hypotheses

authors： Demongeot J,Seligmann H

更新日期：2020-11-01 00:00:00

abstract：:The essential trace element selenium is known to be capable of reducing the toxicity of heavy metals like cadmium(II), mercury(II) and silver(I). One mechanism by which this occurs is through the formation of an inert metal selenide like silver selenide. It is not clear why selenide should react in the body preferenti...

journal_title：Medical hypotheses

authors： Nuttall KL

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:No method is currently available for preoperative approximation of the patient's situation to the one existing during pneumonectomy in general anesthesia with alternations of single and double-lung ventilation in the lateral position. We hypothesized that a patient breathing the room air in the sitting posit...

journal_title：Medical hypotheses

authors： Subotic D,Ercegovac M,Mandaric D,Herth F,Andric Lj,Gajic M

更新日期：2011-10-01 00:00:00

abstract：:Plantar fasciitis has been and remains one of the most common pathologic conditions of the lower extremity. Patients diagnosed with plantar fasciitis are treated conservatively with various degrees of success. This article presents a review of the literature pertaining to treatment of plantar fasciitis as well as intr...

journal_title：Medical hypotheses

authors： Dmitri Luke BS

更新日期：2002-07-01 00:00:00

abstract：:Dyslipidemia is a common pathology throughout the industrialized world, and HMG-CoA reductase inhibitors (statins) are often administered to treat elevated lipid levels. Substantial concern has been raised regarding the aggressive clinical lowering of cholesterol, particularly in light of a growing body of research li...

journal_title：Medical hypotheses

authors： Gendle MH

更新日期：2016-12-01 00:00:00

abstract：:Recent findings demonstrate the vital role of endothelial progenitor cells in the homeostasis of the vessel wall and the development of atherosclerosis. Endothelial progenitor cells (EPCs) play important roles in repair-to-injury of arteries. Many evidences have shown Cardiovascular risk factors closely correlated wit...

journal_title：Medical hypotheses

authors： Zhang M,Zhou SH,Li XP,Shen XQ,Fang ZF

更新日期：2008-01-01 00:00:00

abstract：:An unexpected and novel finding is described and discussed here concerning the synaptic physiology of hippocampal slices during the period of recovery after brain dissection. Contrary to the common notion that the amplitude of synaptic responses recovers in a single exponential rising fashion, we found that synaptic r...

journal_title：Medical hypotheses

authors： Gourov AV

更新日期：2011-12-01 00:00:00

abstract：:Neural tube defect (NTD) is more common among spontaneously aborted fetuses than in infants born in the third trimester, but there is no direct evidence that NTD-affected conceptuses, presenting at these two different gestational ages, are components of a single disease process. Evidence for homology is here presented...

journal_title：Medical hypotheses

authors： Machin GA

更新日期：1979-02-01 00:00:00

abstract：:Gender differences in stem cell population have recently been identified. Blood and tissue samples from women showed consistent elevation of hematopoietic stem cell populations, mesenchymal stem cell populations and endothelial progenitor cells compared to men of similar ages. We and others have shown an increase in h...

journal_title：Medical hypotheses

authors： El-Badri NS,Groer M

更新日期：2012-10-01 00:00:00

abstract：:Growing evidences suggest a link between normal tension glaucoma (NTG) and Alzheimer's disease (AD). Both of them are progressive neurodegenerative disorders. Recently researches provide a clue that optineurin may be a new common underlying risk factor involved in NTG and AD. OPTINEURIN (OPTN) gene coding for "optineu...

journal_title：Medical hypotheses

authors： Liu YH,Tian T

更新日期：2011-10-01 00:00:00

abstract：:Amyloid beta-protein is a major focus in efforts to understand the etiology of Alzheimer disease yet there is little known about the mechanism of its deposition in plaques. I propose deposition of amyloid in neuritic plaques depends on the remains of neurofibrillary tangles after neuronal death. The interaction of the...

journal_title：Medical hypotheses

authors： Perry G

更新日期：1993-04-01 00:00:00

abstract：:The authors hypothesize that the impairment of hypothalamic-pituitary-gonadal axis in patients suffering from anorexia nervosa depends (at least in part) on the increased sensitivity to endogenous melatonin. The hypothesis is based mainly on the following facts: (1) melatonin is well known to exert an inhibitory effec...

journal_title：Medical hypotheses

authors： Pawlikowski M,Zarzycki J

更新日期：1999-02-01 00:00:00

abstract：:This paper discusses a mechanism for converting heterochromatin into the more relaxed state of euchromatin. Actuation of such state conversion stems from disassembly of internal vesicles that are incapable of surviving when trapped within the inner chamber of mammalian nuclei. ...

journal_title：Medical hypotheses

authors： Matioli GT

更新日期：2002-11-01 00:00:00

abstract：:Studies have reported an increasing incidence of thyroid cancer worldwide. The reasons are likely related to improved imaging modalities, altered histopathologic criteria for diagnosis of thyroid cancer, and nuclear exposure. However, the classical assumption derived from epidemiological studies is that it should be q...

journal_title：Medical hypotheses

authors： Gursoy A

更新日期：2010-01-01 00:00:00

abstract：:Neuroleptic-induced tardive dyskinesia represents a major serious side-effect of chronic therapy with neuroleptic drugs. The pathomechanisms underlying this disorder are not well understood. Although the dopaminergic supersensitivity theory has gained most attention, there is evidence to suggest involvement of other t...

journal_title：Medical hypotheses

authors： Sandyk R

更新日期：1986-01-01 00:00:00

abstract：:The AIDS dementia complex and peripheral neuropathy in AIDS are considered to be direct or indirect manifestations of HIV infection, yet the pathogenesis in unclear. There are parallels between AIDS and Tangier disease clinically and histopathologically and in lipid metabolism. The neurological disorders in AIDS may b...

journal_title：Medical hypotheses

authors： Falkenbach A,Klauke S,Althoff PH

更新日期：1990-09-01 00:00:00

abstract：:Medicine today is an extremely heterogeneous field of knowledge, based on clinical observations and action knowledge and on data from the biological, behavioral and social sciences. We hypothesize at first that medicine suffers from a disciplinary hyper-diversity compared to the level of conceptual interdisciplinary i...

journal_title：Medical hypotheses

authors： Tretter F,Löffler-Stastka H

更新日期：2019-12-01 00:00:00

abstract：:Salt is a major mineral element that plays fundamental roles in health and disease. Excessive salt intake is a major cause of hypertension, cardiovascular disease and stroke. Miscarriage and preeclampsia are the most common pregnancy complications with multiple etiological factors, including inflammatory and autoimmun...

journal_title：Medical hypotheses

authors： Abdoli A

更新日期：2016-04-01 00:00:00

abstract：:The etiology of sudden-death ischemic heart disease (SDIHD) remains an enigma. Data will be presented which suggest that SDIHD may be due to hypomagnesemia in and around the coronary arterial and arteriolar vessels. We have found that blood vessels (especially arteries and arterioles) deficient with respect to Mg can ...

journal_title：Medical hypotheses

authors： Altura BM

更新日期：1979-08-01 00:00:00

abstract：:The concept of reentry as the most important element in a hypothesis for consciousness proposed by Edelman and Tononi is reviewed. Reentry, is a process of ongoing parallel and recursive signalling between separate neuronal groups along parallel reciprocally fibers that link these groups anatomically. Reentry alters t...

journal_title：Medical hypotheses

authors： Mellerup E,Kristensen F

更新日期：2004-01-01 00:00:00