Abstract:
:Homocysteine is a sulfur-containing amino acid produced by the breakdown of methionine. Plasma homocysteine levels can be elevated due to a variety of genetic and nutritional factors. Poor nutrition from diets low in folate and vitamin B12 can lead to hyperhomocysteinemia. Mildly elevated levels of homocysteine have been implicated in a number of disease processes such as atherosclerotic vascular disease and adverse obstetrical outcomes. High levels of plasma homocysteine are also associated with abnormal collagen cross-linking. Due to homocysteine's effects on connective tissue integrity, it is hypothesized that hyperhomocysteinemia in pregnancy is associated with preterm premature rupture of membranes (PPROM). Hyperhomocysteinemia, therefore, could be a treatable cause of this important public health concern.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Ferguson SE,Smith GN,Walker MCdoi
10.1054/mehy.2000.1116keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
85-90issue
1eissn
0306-9877issn
1532-2777pii
S0306-9877(00)91116-2journal_volume
56pub_type
杂志文章abstract::The authors sought to establish whether maternal dietary methanol during pregnancy was a factor in the etiology of autism spectrum disorders. A seven item questionnaire was given to women who had given birth to at least one child after 1984. The subjects were solicited from a large primary care practice and several in...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2015.06.025
更新日期:2015-10-01 00:00:00
abstract::Posterior capsule opacification (PCO) is a debilitating and relatively common complication of cataract surgery despite modern medical and surgical advances. The pathophysiology of this condition has largely been attributed to peptide mediators, such as transforming growth factor-beta (TGFβ), epidermal growth factor (E...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.12.042
更新日期:2013-04-01 00:00:00
abstract::In the present study, we used the potential of bioinformatics and computational analysis to predict the existence and biological relevance of zinc finger (ZF) motifs in heamagglutinin (HA) protein of Avian Influenza (AI) virus. Sequence data of Avian Influenza (AI) viruses were retrieved from accessible databases (Gen...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109925
更新日期:2020-11-01 00:00:00
abstract::With spinal anesthesia the level of surgical analgesia is mostly reported without reference to the neuroanatomic map of spinal nerves. The classical maps are variably and inconsistently reported in many textbooks. Because of the differences between the classical maps of Keegan and Garrett and of Foerster, and also bec...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(97)90116-x
更新日期:1997-06-01 00:00:00
abstract::Epidemiological studies reveal that chronic alcoholics exhibiting liver disease are generally malnourished. Experimental studies unequivocally demonstrate that incidence of malnutrition cannot be avoided in animals fed liquid diets containing high concentrations of alcohol. Furthermore, ingestion of additional amounts...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(94)90087-6
更新日期:1994-02-01 00:00:00
abstract::The autoimmune disease rheumatoid arthritis (RA) presents difficulty in diagnosis, commonly observed flare ups, polycyclical nature of RA progression, and variable response to therapies. Congruent with multiple causes, literature has documented various infectious agents, environmental factors, physical trauma, silica ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.10.006
更新日期:2012-01-01 00:00:00
abstract::A hypothesis is proposed here to reconcile the inconsistencies observed in the IQ-P3 latency relation. The hypothesis stems from the observation that task-induced increase in P3 latency correlates positively with IQ scores. It is hypothesised that: (a) there are several parallel information processing pathways of vary...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1999.0979
更新日期:2000-06-01 00:00:00
abstract::Cancer stem cells are presently viewed as carriers of the growth initiating potential, repopulation capability and drug resistance in tumors. However, many of these fundamental properties of cancer are host-related, modified by cell-cell interactions and/or dependent on angiogenesis. Indeed, it is well established tha...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.09.004
更新日期:2006-01-01 00:00:00
abstract::Concerning the damage to back muscles and posterior ligament complex (PLC) by posterior open approach for lumbar spinal stenosis (LSS), the oblique lateral intervertebral fusion (OLIF) is pretty popular nowadays. However, oblique lateral approach has obvious drawbacks, which are limited vision and operative scope for ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.110007
更新日期:2020-11-01 00:00:00
abstract::Recompression and oxygen breathing constitute the primary treatments for decompression sickness (DCS). Increasing the volume of distribution of dissolved gas with high-volume liquid therapy represents an alternative strategy to prevent or treat DCS. Furthermore, degassing of ingested and infused liquids would increase...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(03)00045-8
更新日期:2003-05-01 00:00:00
abstract::Traditional wisdom and empirical observation unite in recommending a 7 year unit for measuring human life - including individual and institutional science. But, because of astronomy and the decimal system, things tend to be measured either in years, five years or in decades. A year is too short while a decade is too l...
journal_title:Medical hypotheses
pub_type: 社论
doi:10.1016/j.mehy.2006.02.017
更新日期:2006-01-01 00:00:00
abstract::Auer rods are cytoplasmic inclusions found only in the leukaemic cells of some cases of acute myeloid leukaemia (AML). The ultrastructure of Auer rods is different in different sub-types of the disease and it is suggested here that this may be a consequence of the Auer rods consisting of different crystalline forms of...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(89)90058-3
更新日期:1989-11-01 00:00:00
abstract::Currently, several prominent researchers are investigating the role of reactive oxygen and free radicals in the activation of latent HIV in infected individuals. Early clinical applications of free radical scavengers and plant-based antioxidant systems have shown promise of efficacy in altering this process. This manu...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90133-b
更新日期:1993-02-01 00:00:00
abstract::Inotropic treatment remains the cornerstone for cardiogenic shock, an emergency that requires immediate resuscitative therapy before shock irreversibly damages vital organs. Although the sympathomimetic drug dobutamine is the most widely-used inotropic drug worldwide, it has several side effects including sinus tachyc...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.05.002
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is the most common cardiac arrhythmia. Many studies have investigated the cause for the development of AF, however, the question remains unanswered. METHODS:A comparison of hydrodynamics between AF and sinus rhythm was performed. RESULTS:I proposed the hypothesis that atrial fibril...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2015.11.028
更新日期:2016-01-01 00:00:00
abstract::The incidence of insulin-dependent diabetes mellitus (IDDM), a chronic disease with a well-known genetic basis, is highest in Scandinavian and Sardinian populations. The high incidence of IDDM in Scandinavia and Sardinia, which were genetically isolated from the spread of agriculturists in Europe about 8000 years ago,...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1997.0663
更新日期:1999-05-01 00:00:00
abstract::Stress, in its many forms, is long associated with the etiology and course of schizophrenia. The mechanisms mediating the impacts of stress are not fully elucidated. Here it is proposed that stress induced cortisol alters kynurenic acid (KA) and quinolinic acid (QA) in the cortex and amygdala/striatum, respectively. T...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.08.029
更新日期:2011-01-01 00:00:00
abstract::The type of treatment that most psychiatric disturbances receive at present is a mixture of pharmacotherapy and psychotherapy, following the principle that mental functions are the result of the activities of brain machinery subsequent to the interaction between individuals and their external environment. We now know ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1997.0774
更新日期:1999-01-01 00:00:00
abstract::A steady fall in mortality rates from cardiovascular diseases (CVD) has been reported recently in the United States. This study tests the hypothesis that fruits and vegetables had a protective effect against cardiovascular mortality among the American population from 1964-78. Special attention was focused on more spec...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(85)90035-0
更新日期:1985-01-01 00:00:00
abstract::Dream periods during sleep have been observed in most mammals as early in history as antiquity. Sleep researchers at the University of Chicago, discovered the phase of rapid eye movement (REM) during sleep and connected it to the dream period. During this period, called the REM phase (after the American terminology), ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.03.027
更新日期:2019-06-01 00:00:00
abstract::It is well known, that most of the psychiatric diseases affect various neurotransmitter systems. It is the aim of this profile to define a set of cheap analyses, indicative for a specific psychiatric disease, to facilitate differential diagnosis and to offer an additional tool to the already existing clinical-descript...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.06.023
更新日期:2011-10-01 00:00:00
abstract::It is well documented that depressed patients, as a result of their illness, often experience some difficulties with their memory. This hypothesis suggests a vice-versa; that it is a gradual impairment and ultimate failure of specific memory systems that may underpin the onset and continuation of a depressive illness....
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.01.046
更新日期:2007-01-01 00:00:00
abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.07.027
更新日期:2012-08-20 00:00:00
abstract::Multiple reports show the efficacious usage of ECT for catatonia in individuals with autism. There are also a few reports showing that ECT improves self-injury in people with and without autism. In this hypothesis, self-injury in autism and other developmental disorders may be an alternate sign of catatonia, and as su...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.02.001
更新日期:2010-07-01 00:00:00
abstract::We suggest that polymyalgia rheumatica with giant cell arteritis (PR-GCA) is an arachidonic acid metabolites mediated disease which can be diagnosed more accurately and monitored more precisely for therapeutic benefits by the serial determinations of the major urinary prostaglandin F, serum urinary lysozymes, serum ac...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(81)90059-1
更新日期:1981-09-01 00:00:00
abstract::Rodent studies reveal that oxidative stress, much of it generated via induction/activation of NADPH oxidase, is a key mediator of a number of the pathogenic effects of chronic ethanol overconsumption. The highly reactive ethanol metabolite acetaldehyde is a key driver of this oxidative stress, and doubtless works in o...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.12.040
更新日期:2013-04-01 00:00:00
abstract::Diabetes mellitus, a metabolic disorder with significant global health care burden, causes chronic microvascular and macrovascular complications that still comprise a therapeutic challenge. Angiotensin-(1-7), a heptapeptide with vasodilatory properties, has been found to restore vascular reactivity and endothelial cel...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.05.010
更新日期:2016-08-01 00:00:00
abstract::The possibility that Hematopoiesis is under CNS control has been discussed in the literature; but never been conclusively proved at the molecular level. Evidence in the form of antigenic similarity between murine brain and the Stem Cell, and the decline in the number of Stem Cells following the lesioning of the Locus ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(88)90010-2
更新日期:1988-12-01 00:00:00
abstract::This hypothesized reflex relates the vertical direction of gaze to the amount of tension exerted by the ciliary muscle. Based on simple observations the following is assumed. When looking downwards a tendency for closer focusing (near searching) exists even without a specific visual stimulus, whereas looking up favors...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(91)90016-r
更新日期:1991-12-01 00:00:00
abstract::The affected individual of hair loss demands help, because hair is viewed as a sign of youth and good health. Nowadays treatment of alopecia includes drug therapy and hair transplantation. Some drugs may promote hair growth, at least temporarily, but the treatment is effective only in milder alopecia, instead of exten...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.09.001
更新日期:2008-01-01 00:00:00