Maternal plasma homocysteine levels in women with preterm premature rupture of membranes.

Abstract:

:Homocysteine is a sulfur-containing amino acid produced by the breakdown of methionine. Plasma homocysteine levels can be elevated due to a variety of genetic and nutritional factors. Poor nutrition from diets low in folate and vitamin B12 can lead to hyperhomocysteinemia. Mildly elevated levels of homocysteine have been implicated in a number of disease processes such as atherosclerotic vascular disease and adverse obstetrical outcomes. High levels of plasma homocysteine are also associated with abnormal collagen cross-linking. Due to homocysteine's effects on connective tissue integrity, it is hypothesized that hyperhomocysteinemia in pregnancy is associated with preterm premature rupture of membranes (PPROM). Hyperhomocysteinemia, therefore, could be a treatable cause of this important public health concern.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Ferguson SE,Smith GN,Walker MC

doi

10.1054/mehy.2000.1116

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

85-90

issue

1

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(00)91116-2

journal_volume

56

pub_type

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