Abstract:
:Auer rods are cytoplasmic inclusions found only in the leukaemic cells of some cases of acute myeloid leukaemia (AML). The ultrastructure of Auer rods is different in different sub-types of the disease and it is suggested here that this may be a consequence of the Auer rods consisting of different crystalline forms of the enzyme myeloperoxidase. There is statistical evidence to indicate that patients with Auer rods have a more favourable prognosis than those without. It is proposed that an investigation of the factors that determine the form, if any, of the crystallisation of myeloperoxidase will lead to a better understanding of the molecular events underlying the different types of AML. In the long term this may in turn lead to a therapeutic advance.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Pearson ECdoi
10.1016/0306-9877(89)90058-3subject
Has Abstractpub_date
1989-11-01 00:00:00pages
175-7issue
3eissn
0306-9877issn
1532-2777pii
0306-9877(89)90058-3journal_volume
30pub_type
杂志文章abstract::The modern living standard has imposed upon society a situation of chronic sleep deprivation. This chronic loss of sleep affects women more than it does men. As a result, the postponement of pregnancy has become a common choice due to the priority given to social and domestic activities. For women, pregnancy represent...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.07.036
更新日期:2010-12-01 00:00:00
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(96)90071-7
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章,评审
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章,评审
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更新日期:1989-09-01 00:00:00
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journal_title:Medical hypotheses
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pub_type: 信件
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(90)90184-g
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2000.1221
更新日期:2001-06-01 00:00:00
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journal_title:Medical hypotheses
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doi:10.1016/j.mehy.2016.01.013
更新日期:2016-03-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(80)90104-8
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journal_title:Medical hypotheses
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doi:10.1016/j.mehy.2004.03.013
更新日期:2004-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.06.027
更新日期:2008-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.05.019
更新日期:2013-08-01 00:00:00
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journal_title:Medical hypotheses
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doi:10.1016/s0306-9877(98)90080-9
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(92)90034-a
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(92)90007-y
更新日期:1992-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(98)90007-x
更新日期:1998-04-01 00:00:00