Extracellular volume regulation and growth.

abstract：:The paper based on the hypothesis that mechanical impulses cause the transmission of excitement in the peripheral and central nervous system. Possible connections between changes in the tubular neuronal network and the morphological findings of Alzheimer's disease are presented. Additionally, changes in the viscosity ...

journal_title：Medical hypotheses

authors： Barz H,Barz U

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Geldanamycin, which is one of the most potent and effective hsp90 alpha inhibitor until date, is normally used to target breast cancer. Inhibition of hsp90 alpha leads to the degradation of client proteins involved in the initiation and progress of breast cancer pathogenesis. Hence, Geldanamycin has been wid...

journal_title：Medical hypotheses

authors： Mahanta S,Pilla S,Paul S

更新日期：2013-09-01 00:00:00

abstract：:The new prion diseases that have emerged in the last 15 years are bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (variant CJD). Although initially confined to the UK, these diseases have recently emerged in other European countries. The accepted cause of the human disease is that BSE spre...

journal_title：Medical hypotheses

authors： Brown DR

更新日期：2001-11-01 00:00:00

abstract：:The rise of anatomical realism in sculpture with the Classical Greeks puzzles art historians. Recently, it has been discovered that the motor cortex perceives motor actions. I argue that Classical artists discovered a new aesthetic based on using art to stimulate not just, as previously, the visual cortex, but also th...

journal_title：Medical hypotheses

authors： Skoyles JR

更新日期：1998-07-01 00:00:00

abstract：:Many theories try to explain the existence and function of paranasal sinuses. This paper is an attempt to correlate process of paranasal sinus development in human with bone pneumatization processes in animals. It is here proposed that this mechanism starts in utero and continues after birth. During endochondral devel...

journal_title：Medical hypotheses

authors： Kurbel S,Radić R,Kristek B,Ivezić Z,Selthofer R,Kotromanović Z

更新日期：2004-01-01 00:00:00

abstract：:Recent studies confirm that dietary methionine restriction increases both mean and maximal lifespan in rats and mice, achieving "aging retardant" effects very similar to those of caloric restriction, including a suppression of mitochondrial superoxide generation. Although voluntary caloric restriction is never likely ...

journal_title：Medical hypotheses

authors： McCarty MF,Barroso-Aranda J,Contreras F

更新日期：2009-02-01 00:00:00

abstract：:Schmorl's nodes (SNs) are common abnormalities in the human spine, which represent herniation of the nucleus pulposus of the intervertebral disc into the adjacent cartilaginous endplate of the vertebra. However, the principle mechanism of SNs is still not fully understood. And the relationship of SNs in the spine and ...

journal_title：Medical hypotheses

authors： Zhang N,Li FC,Huang YJ,Teng C,Chen WS

更新日期：2010-03-01 00:00:00

abstract：:Burnout is a state of physical or mental collapse caused by overwork or stress. Burnout during residency training has gained significant attention secondary to concerns regarding job performance and patient care. The new COVID-19 pandemic has raised public health problems around the world and required a reorganization...

journal_title：Medical hypotheses

authors： Dimitriu MCT,Pantea-Stoian A,Smaranda AC,Nica AA,Carap AC,Constantin VD,Davitoiu AM,Cirstoveanu C,Bacalbasa N,Bratu OG,Jacota-Alexe F,Badiu CD,Smarandache CG,Socea B

更新日期：2020-11-01 00:00:00

abstract：:This paper describes a model which puts together three key elements of cancer theory: the analogies between embryogenesis and carcinogenesis, the role played in both processes by morphogens and related pathways, and the recently emerged paradigm of cancer stem cells. The model is called Epigenetic Tracking. Originally...

journal_title：Medical hypotheses

authors： Fontana A,Wróbel B

更新日期：2013-10-01 00:00:00

abstract：:Viral infections are often the etiological agents of severe acute and chronic human diseases. Their peculiar biology usually leads to the need of design specific therapies for each virus, and the eradication of the viruses and the healing of the patients very often are not reached also after decades of theoretical and...

journal_title：Medical hypotheses

authors： Arancio W

更新日期：2012-09-01 00:00:00

abstract：:Immune competence is considered as a state of equilibrium between humoral and cellular immunity. This notion fits well with the functionally antagonistic cytokine profiles in cell groups of CD4(+)-helper cells as described by Mosmann and Coffman. The Th-1 cells release mainly IL-2, IL-12 and IFN gamma and thereby stim...

journal_title：Medical hypotheses

authors： Hässig A,Wen-Xi L,Stampfli K

更新日期：1996-06-01 00:00:00

abstract：:Late luteal phase dysphoric disorder is described as a classic biopsychosocial disorder resulting from complex interactions of biological, psychological, socioeconomic and cultural forces on women. To understand women suffering from the disorder, one must understand how the genetically designed female brain and body i...

journal_title：Medical hypotheses

authors： Severino SK

更新日期：1993-09-01 00:00:00

abstract：:Low carbohydrate high fat (LCHF) diets are emerging in popularity. Several athletics have adopted LCHF diets in an attempt to improve exercise performance and body composition by enhancing fat utilization. However, these diets impair maximal and supramaximal exercise performance due to limited glycogen stores as well ...

journal_title：Medical hypotheses

authors： Kaviani M,Izadi A,Heshmati J

更新日期：2021-01-01 00:00:00

abstract：:Gas formed in tissues and the circulating blood due to decompression is thought to be a significant factor in the progression of decompression illness (DCI). DCI is a potential problem for a growing population of professional and recreational divers. We hypothesise that these gas bubbles are not the causative agent in...

journal_title：Medical hypotheses

authors： Madden LA,Laden G

更新日期：2009-04-01 00:00:00

abstract：:Following observation of fatigue syndromes in people who have been occupationally exposed to pesticides and insecticides which exert their toxicity through the GABAa receptor, we have formulated the hypothesis that fatigue syndromes in general may be secondary to altered sensitivity of the GABAa receptor. We discuss t...

journal_title：Medical hypotheses

authors： Corrigan FM,MacDonald S,Brown A,Armstrong K,Armstrong EM

更新日期：1994-10-01 00:00:00

abstract：:IGF-I acts on vascular endothelium to activate nitric oxide synthase, thereby promoting vascular health; there is reason to believe that this protection is especially crucial to the cerebral vasculature, helping to ward off thrombotic strokes. IGF-I may also promote the structural integrity of cerebral arteries, there...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2003-09-01 00:00:00

abstract：:The malignant cell, in vivo, metabolizes and respires anaerobically. For a good many years scientists have been aware of anaerobia being present in malignant growths. The prevailing opinion is that the malignant cell is able to remain viable in an anaerobic medium. This assumption is incorrect and is actually misleadi...

journal_title：Medical hypotheses

authors： White MW

更新日期：1992-12-01 00:00:00

abstract：:Inflammation and the genes, molecules, and biological pathways that lead to inflammatory processes influence many important and disparate biological processes and disease states that are quite often not generally considered classical inflammatory or autoimmune disorders. These include development, reproduction, aging,...

journal_title：Medical hypotheses

authors： Becker KG

更新日期：2007-01-01 00:00:00

abstract：:Current tuberculosis control measures are focused on the prompt detection and treatment of active tuberculosis. Despite the measured success of this strategy, tuberculosis continues to be a public health issue of major significance around the world. This unwanted situation suggests the need to expand our control effor...

journal_title：Medical hypotheses

authors： Mao F,Chen T,Zhao Y,Zhang C,Bai B,Zhao S,Xu Z,Shi C

更新日期：2011-07-01 00:00:00

abstract：:In addition to classical metastatic pathways, recently gastric cancer was described having an alternative route called "endoluminal exfoliation". Provisional analyses demonstrated, in fact, this kind of shedding is associated with several clinico-pathological features indicative of aggressive behavior and resulted to ...

journal_title：Medical hypotheses

authors： Virgilio E,Balducci G,Mercantini P,Giarnieri E,Giovagnoli MR,Montagnini M,Proietti A,D'Urso R,Cavallini M

更新日期：2018-05-01 00:00:00

abstract：:Epidemiologic literatures suggest that temporomandibular joint disorders (TMD) are more prevalent in women than in men. It is affecting approximately 7-15% of the adult population in North America, and 80% of patients treated for TMD are women. The severity of symptoms is also related to the age of the patients. The g...

journal_title：Medical hypotheses

authors： Wang J,Chao Y,Wan Q,Zhu Z

更新日期：2008-10-01 00:00:00

abstract：:Drug biotransformations are controlled in the body by tissue-differentiated choice of a selection of the induced and constitutive 57 isoforms of the human cytochromes P450 (CYP). CYP are the mixed function oxidase enzyme family (EC 1.14.14.1: mono-oxygenases that contain iron-dependent protohaematin IX). Many of the m...

journal_title：Medical hypotheses

authors： Wiseman A

更新日期：2005-01-01 00:00:00

abstract：:Triggering receptor expressed on myeloid cells-1 (TREM-1) is a recently identified cell surface receptor that is expressed mainly on monocytes and neutrophils, and plays an important role as an amplifier of inflammatory response in acute and chronic inflammatory conditions. Recent studies suggested that TREM-1 contrib...

journal_title：Medical hypotheses

authors： Kim TH,Choi SJ,Lee YH,Song GG,Ji JD

更新日期：2012-02-01 00:00:00

abstract：:To discuss the possible pathogenesis of outlet obstructive constipation (OOC) and identify the theoretical basis of the Procedure for Prolapse and Hemorrhoids (PPH) used to treat outlet obstructive constipation (OOC). 19 patients diagnosed with outlet obstructive constipation (OOC) form the case group, and 9 healthy v...

journal_title：Medical hypotheses

authors： Qin Z,Pang L,Dai W,Yan W,Zhang J,Zhao Y,Li Q,Wu K,Zhou B

更新日期：2015-07-01 00:00:00

abstract：:The mechanism by which polyglutamine expansions in several proteins lead to neurodegenerative disorders remains largely unknown. The biochemical properties of polyglutamine repeats suggest one possible explanation; endolytic cleavage at a glutaminyl-glutaminyl bond followed by pyroglutamate formation may contribute to...

journal_title：Medical hypotheses

authors： Saido TC

更新日期：2000-03-01 00:00:00

abstract：:Based on a consideration of biochemical mechanisms, rational methods for the prevention of cancer and for its positive regression are presented. It is demonstrated that the means employed are fundamentally opposed so that if the preventive method were to be used after the onset of cancer, it would only accelerate its ...

journal_title：Medical hypotheses

authors： Duchesne J

更新日期：1981-04-01 00:00:00

abstract：:This hypothesized reflex relates the vertical direction of gaze to the amount of tension exerted by the ciliary muscle. Based on simple observations the following is assumed. When looking downwards a tendency for closer focusing (near searching) exists even without a specific visual stimulus, whereas looking up favors...

journal_title：Medical hypotheses

authors： Blumenthal EZ

更新日期：1991-12-01 00:00:00

abstract：:We describe a six-month-old girl with microcephaly, developmental delay, truncal hypotonia, left pyramidal signs, partial seizures and myoclonic spasms, born to a feverish mother. MRI showed bilateral vascular lesions in the territory of the middle cerebral arteries, prevalent in the right hemisphere, together with hy...

journal_title：Medical hypotheses

authors： Spalice A,Del Balzo F,Papetti L,Nicita F,Ursitti F,Salvatori G,Iannetti P

更新日期：2011-08-01 00:00:00

abstract：:The German doctor Hermann Kümmell described Kümmell's disease as the clinical scenario in which patients suffer a trivial spinal trauma, but develop a symptomatic, progressive, angular kyphosis after a symptom-free period of months to years. Since an intravertebral vacuum phenomenon, which is considered indicative of ...

journal_title：Medical hypotheses

authors： Li H,Liang CZ,Shen CC,Chen QX

更新日期：2011-11-01 00:00:00

abstract：:Metastasis is the leading cause of cancer death, yet it is mechanistically considered a very inefficient process suggesting the presence of some sort of (e.g. systemic) routes for fuelling the process. The pre-metastatic niche formation is described as one such metastasis promoting route. Now, the emerging potentials ...

journal_title：Medical hypotheses

authors： Ghasemi R,Grassadonia A,Tinari N,Piccolo E,Natoli C,Tomao F,Iacobelli S

更新日期：2013-01-01 00:00:00