Auto-immune therapy against human allergic disease: a physiological self defence factor.

abstract：:Previous research from our group suggests that patients with lesions in the left inferior parietal lobule (IPL)-which is concerned with abstract numerical cognition and cross-modal association (which is consistent with its strategic location at the crossroads between the temporal, parietal and occipital lobes) have di...

journal_title：Medical hypotheses

authors： Jalal B,Ramachandran VS

更新日期：2014-06-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Medical hypotheses

authors： Dillon SP,Kurien BT,Maier-Moore JS,Wiley GB,Gaffney PM,Scofield RH

更新日期：2012-08-20 00:00:00

abstract：:The paper discusses certain dynamic processes leading to meiotic (haploid) partition of chromatids via the chiasmatic mode in mammalian spermatic cells. The achiasmatic case is also reviewed briefly and only in the context of homologs with centromeric braids arrayed in the Para configuration. ...

journal_title：Medical hypotheses

authors： Matioli GT

更新日期：1994-12-01 00:00:00

abstract：:It is postulated that the metabolically variable fine structure of pericellular heparan glycosaminoglycans affects the ability of these molecules to influence cell proliferation-associated proteinase-catalysed reactions occurring at cell surfaces. Evidence suggesting the possibility of a wide repertoire of glycosamino...

journal_title：Medical hypotheses

authors： Long WF,Williamson FB

更新日期：1983-07-01 00:00:00

abstract：:The clinical syndrome of hypoxic ischemic encephalopathy (HIE) which occurs in association with birth asphyxia, is thought to represent a reperfusion injury consequent upon the generation of cytotoxic oxygen derived free radicals. It has recently been suggested that resuscitation of asphyxiated infants with unrestrict...

journal_title：Medical hypotheses

authors： Ballot DE,Rothberg AD,Davies VA,Smith J,Kirsten G

更新日期：1993-10-01 00:00:00

abstract：:Atrial fibrillation (Af) is the most common disorder of cardiac rhythm and is responsible for substantial morbidity and mortality in the general population. A recent community-based observational study revealed that diabetes and hypertension were associated with the development of Af. Since there is no definite eviden...

journal_title：Medical hypotheses

authors： Yamagishi S,Takenaka K,Inoue H

更新日期：2006-01-01 00:00:00

abstract：:Despite aggressive intervention, patients who survive an out-of-hospital cardiac arrest (OHCA) generally have very poor prognoses, with nationwide survival rates of approximately 10-20%. Approximately 90% of survivors will have moderate to severe neurological injury ranging from moderate cognitive impairment to brain ...

journal_title：Medical hypotheses

authors： Gul SS,Huesgen KW,Wang KK,Mark K,Tyndall JA

更新日期：2017-08-01 00:00:00

abstract：:Numerous studies implicate cellular immunological effector systems in the partial containment of virus replication during the early stages of HIV infection. Immunostimulatory therapeutic regimes designed to enhance virus clearance are therefore theoretically attractive, but are accompanied by the risk of concomitant a...

journal_title：Medical hypotheses

authors： Wrightham MN,Cann AJ,Sewell HF

更新日期：1992-07-01 00:00:00

abstract：:The various neurotransmitter systems postulated to be involved in the pathogenesis of Gilles de la Tourette syndrome(GTS) are described with special reference to the endogenous opioid system(EOS). Malfunction of the opioid system is proposed as the underlying disturbance in this disease causing secondary dysfunction o...

journal_title：Medical hypotheses

authors： Gillman MA,Sandyk R

更新日期：1986-04-01 00:00:00

abstract：:Hyperplasia of the coronoid process of the mandible has been observed in conditions like Oral submucous fibrosis, TMJ ankylosis, etc. The etiopathogenesis of this coronoid overgrowth has not been clearly sequenced or adequately hypothesized, and no definite mechanism has so far been advocated to explain this elongatio...

journal_title：Medical hypotheses

authors： Chakranarayan A,Jeyaraj P

更新日期：2011-11-01 00:00:00

abstract：:Hypertensive left ventricular hypertrophy (LVH) is a maladaptive response to chronic pressure overload and a strong independent risk factor for cardiovascular disease. Regression of LVH is associated with improved prognosis. Regression of LVH with antihypertensive therapy (angiotensin-converting enzyme inhibitors, ang...

journal_title：Medical hypotheses

authors： Quintana-Villamandos B,Delgado-Baeza E

更新日期：2016-02-01 00:00:00

abstract：:A major factor relating to the oversight of neurological dysfunction and seizures caused by magnesium (Mg++) depletion, involves the buffer functions of the skeletal system orchestrated primarily by the parathyroid. A Mg++ depleted subject may appear relatively asymptomatic until a short period after homeostatic respo...

journal_title：Medical hypotheses

authors： Langley WF,Mann DJ

更新日期：1991-01-01 00:00:00

abstract：:To discuss the possible pathogenesis of outlet obstructive constipation (OOC) and identify the theoretical basis of the Procedure for Prolapse and Hemorrhoids (PPH) used to treat outlet obstructive constipation (OOC). 19 patients diagnosed with outlet obstructive constipation (OOC) form the case group, and 9 healthy v...

journal_title：Medical hypotheses

authors： Qin Z,Pang L,Dai W,Yan W,Zhang J,Zhao Y,Li Q,Wu K,Zhou B

更新日期：2015-07-01 00:00:00

abstract：:Although Still's disease has been first described more than one century ago, it still appears as an orphan entity, which should be separated from the other auto-inflammatory diseases (AID). The main reason to individualize Still's disease among the AID is the absence of any genetic predisposition. Recently, the human ...

journal_title：Medical hypotheses

authors： Hayem F,Hayem G

更新日期：2012-08-01 00:00:00

abstract：:One of the most affected cognitive impairments in children who experienced heavy burdens of diarrhea is semantic fluency, the same impairment that is most affected in Alzheimer's dementia. These findings are leading us into provocative genetic studies that may elucidate the evolution of such genetic polymorphisms as t...

journal_title：Medical hypotheses

authors： Oriá RB,Costa CM,Lima AA,Patrick PD,Guerrant RL

更新日期：2009-11-01 00:00:00

abstract：:Cholesterol efflux from macrophage foam cells, the initial step of reverse cholesterol transport, is assumed to be the most relevant step with respect to atherosclerosis. As one of the ATP-binding cassette transporter (ABC) family members, ABCG1 plays a critical role in the process of cholesterol efflux. It has been r...

journal_title：Medical hypotheses

authors： Ni ZL,Zhao SP,Wu Z

更新日期：2007-01-01 00:00:00

abstract：:Neuroleptic-induced tardive dyskinesia represents a major serious side-effect of chronic therapy with neuroleptic drugs. The pathomechanisms underlying this disorder are not well understood. Although the dopaminergic supersensitivity theory has gained most attention, there is evidence to suggest involvement of other t...

journal_title：Medical hypotheses

authors： Sandyk R

更新日期：1986-01-01 00:00:00

abstract：:Many brilliant and ambitious young women lose their drive for top careers after childbirth. New maternal impulses are at odds with their original ambitions and for many mothers stress and frustration will be the result as they have to combine child care with workweeks of 60-80h to reach or remain at the top. Pregnancy...

journal_title：Medical hypotheses

authors： Schulpen TWJ

更新日期：2017-09-01 00:00:00

abstract：:The etiology of focal distribution of atherosclerotic lesions has received much attention for many years. Current theories focus on mechanical factors such as low endothelial shear stress as an initiating factor for atherosclerosis formation. However, some evidences revealed that it could not be initiator of endotheli...

journal_title：Medical hypotheses

authors： Mehdizadeh A,Norouzpour A

更新日期：2009-12-01 00:00:00

abstract：:Tourette syndrome is a chronic, idiopathic, childhood onset neuropsychiatric disorder with both motor and vocal tics. Tourette syndrome occurs worldwide and the clinical features are similar irrespective of the country of origin, with genetic causes suspected, but to date not proven. A link between red hair colour and...

journal_title：Medical hypotheses

authors： Sterling-Levis K,Williams K

更新日期：2009-11-01 00:00:00

abstract：:Mood disturbances and depression are supposed to have a negative impact on patients' outcome in malignant tumour disease. On the other hand, poor prognosis in cancer patients is associated with chronic immune challenge which is paralleled by enhanced degradation of the essential amino acid tryptophan and thus decrease...

journal_title：Medical hypotheses

authors： Murr C,Widner B,Sperner-Unterweger B,Ledochowski M,Schubert C,Fuchs D

更新日期：2000-08-01 00:00:00

abstract：:Metastases from unknown primary tumours (MUP) are not an uncommon clinical problem. A hypothesis that discusses the plausible role of neoangiogenesis, as a central theme in the development of MUPs, is presented. Invasive cancers, which cannot or do not switch to the angiogenic phenotype, remain subclinical. In situati...

journal_title：Medical hypotheses

authors： Naresh KN

更新日期：2002-09-01 00:00:00

abstract：:About 19-26% of patients with chronic lymphocytic leukemia (CLL) have intractable disease resistant to chemotherapy, have a relatively short median survival time and are responsive to splenectomy. Lymphocytes from patients with intractable CLL are resistant in vitro to X-irradiation and to colchicine. Responsive CLL i...

journal_title：Medical hypotheses

authors： Schrek R

更新日期：1990-02-01 00:00:00

abstract：:The etiologic basis of urinary tract anomalies and dysfunctional voiding largely remain unknown. However, the travel of urine from renal pelvis into the amniotic cavity under the pressures exerted by amniotic fluid satisfactorily explains the etiologic basis. Amniotic pressure is affected by the changes in maternal in...

journal_title：Medical hypotheses

authors： Tanyel FC

更新日期：2000-01-01 00:00:00

abstract：:Many experimental evidences indicate that infection with Trypanosoma cruzi delays or inhibits the growth of malignant tumors in different strains of mice and in rats. These facts were verified by different workers. Although earlier workers proposed that this effect would be due to a toxin of T. cruzi, most of the accu...

journal_title：Medical hypotheses

authors： Cabral HR

更新日期：2000-01-01 00:00:00

abstract：:Pseudohypoaldosteronism Type I may occur due to several different causes. The authors recommend distinguishing between effector and receptor disorders with regard to the diverse mode of inheritance and prognosis. ...

journal_title：Medical hypotheses

authors： Bayer M,Kutílek S

更新日期：1993-09-01 00:00:00

abstract：:Reversing chronic conditions remains an elusive goal of medicine. The modern medical paradigm based on blocking overactive pathways or augmenting deficient pathways offers symptomatic benefit, but tolerance to therapy can develop and treatment cessation can produce rebound symptoms due to compensatory mechanisms. We p...

journal_title：Medical hypotheses

authors： Yun AJ,Lee PY,Bazar KA

更新日期：2005-01-01 00:00:00

abstract：:The nasal mucosa is very vascular, receiving more blood flow per cubic centimeter of tissue than does muscle, brain or liver (Drettner and Aust, 1974; [1]). This vascularity can present a major problem during sinus surgery. Surgeons routinely use topical vasoconstrictors in endoscopic sinus surgery however, the optima...

journal_title：Medical hypotheses

authors： Campbell RG,Nair S,Sacks R,Douglas RG

更新日期：2014-06-01 00:00:00

abstract：:Oxidative stress-mediated neurodegeneration is responsible for 12% mortality around the globe. Alzheimer's Disease (AD) and Parkinson's Disease (PD) are the most prevalent neurodegenerative diseases, associated with modulation of acetylcholine levels and amyloid beta accumulation & dopamine level and alpha-synuclein o...

journal_title：Medical hypotheses

authors： Krishnaswamy VKD,Alugoju P,Periyasamy L

更新日期：2020-10-01 00:00:00

abstract：:Recent work by molecular biologists into the behaviour of progesterone receptors (PR) has suggested an aetiological hypothesis for premenstrual syndrome (PMS). The proposition is that PMS is related to the transport by PR of sufficient progesterone (P) molecules into the cell nuclei during menstruating years. PR are w...

journal_title：Medical hypotheses

authors： Dalton K

更新日期：1990-04-01 00:00:00