New insights in atherosclerosis: endothelial shear stress as promoter rather than initiator.

abstract：:Immune competence is considered as a state of equilibrium between humoral and cellular immunity. This notion fits well with the functionally antagonistic cytokine profiles in cell groups of CD4(+)-helper cells as described by Mosmann and Coffman. The Th-1 cells release mainly IL-2, IL-12 and IFN gamma and thereby stim...

journal_title：Medical hypotheses

authors： Hässig A,Wen-Xi L,Stampfli K

更新日期：1996-06-01 00:00:00

abstract：:Intestinal dysbiosis refers to an imbalance in the intestinal flora. The concept of small intestinal bacterial overgrowth (SIBO), a condition of abnormal proliferation of the small intestine microbiota, has been proposed as a form of small intestine dysbiosis. In Parkinson's disease patients, weight loss and metabolic...

journal_title：Medical hypotheses

authors： Hasuike Y,Endo T,Koroyasu M,Matsui M,Mori C,Yamadera M,Fujimura H,Sakoda S

更新日期：2020-01-01 00:00:00

abstract：:NETosis, being an alternative form of cell death is the creation of web-like chromatin decondensates by suitably primed neutrophils as a response to stimulus aimed at containing and eliminating the same. In certain situations, it causes more harm than benefit in the form of bystander damage directly or via activation ...

journal_title：Medical hypotheses

authors： Gupta S,Sahni V

更新日期：2020-11-01 00:00:00

abstract：:Endometriosis is a common gynaecological disorder causing pain, infertility, and emotional distress. Evidence presented here suggests that abnormal production of tumour necrosis factor-alpha (TNF-alpha) is required for the establishment and maintenance of endometriosis and also is responsible for the associated infert...

journal_title：Medical hypotheses

authors： Bullimore DW

更新日期：2003-01-01 00:00:00

abstract：:Acute disseminated encephalomyelitis (ADEM) is defined as a multifocal, monophasic, demyelinating, and inflammatory disease involving the central nervous system. It typically begins within 6 weeks of an antigenic challenge such as infection or immunization. Perivenous inflammation, edema and demyelination are the path...

journal_title：Medical hypotheses

authors： Sabayan B,Zolghadrasli A

更新日期：2007-01-01 00:00:00

abstract：:Organogenesis is the result of cell allocation followed by cell differentiation, and the processes involved are still to be elucidated. Present-day teaching suggests that the cytoplasmic membrane, the extracellular matrix and the cytoskeleton, in combination, are responsible, but the literature also suggests that othe...

journal_title：Medical hypotheses

authors： Drummond R

更新日期：1996-03-01 00:00:00

abstract：:The efficiency of anti-tumour drug strongly depends on its dose. Higher drug doses and exposure times usually result in better treatment. It is why the implementation of high-dose treatment is always attractive. However, most of the drug delivery techniques meet essential limitations. In isolated regional perfusion a ...

journal_title：Medical hypotheses

authors： Rukhlenko OS,Guria GT,Vorobiev AI

更新日期：2017-07-01 00:00:00

abstract：:In endemic pemphigus foliaceus (EPF) or "fogo selvagem" the epidemiological evidence shows that all the described outbreaks occur on the banks of rivers where there is mercury contamination from alluvium gold mining and deforestation. Pathophysiological evidence shows a similarity to pemphigus induced by sulphydryl (S...

journal_title：Medical hypotheses

authors： Robledo MA

更新日期：2012-01-01 00:00:00

abstract：:Incretin hormones have trophic effects on beta cell function that can aid prevention and treatment of diabetes. cAMP is the primary mediator of these effects, and has been shown to potentiate glucose-stimulated insulin secretion, promote proper beta cells differentiation by increasing expression of the crucial transcr...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2006-01-01 00:00:00

abstract：:The 2013 American Heart Association Blood Cholesterol Guidelines increased the number of patients recommended for statin therapy in the United States to 56million. Two common statin side effects are muscle pain, referred to as "statin-associated muscle symptoms", and increased risk for new onset type-2-diabetes mellit...

journal_title：Medical hypotheses

authors： Carris NW,Tipparaju SM,Magness DJ,Chapalamadugu KC,Magness RR

更新日期：2017-09-01 00:00:00

abstract：:The classical form of Barlow's disease or infantile scurvy, with bruises, broken bones and sores that will not heal, is rarely seen today, but it seems to be reappearing under a different guise, when infants with borderline vitamin C depletion are assaulted with too many inoculations at one time.Moreover, it is now so...

journal_title：Medical hypotheses

authors： Clemetson CA

更新日期：2002-07-01 00:00:00

abstract：:Preliminary reports have demonstrated that anterior nucleus thalamus high-frequency electrical stimulation (ANT-HFS) is an effective treatment for patients who suffer from medically refractory epilepsy. However, its extensive application has been hampered by the high cost and the unpredictable outcome before the opera...

journal_title：Medical hypotheses

authors： Yan N,Chen N,Lu J,Wang Y,Wang W

更新日期：2013-09-01 00:00:00

abstract：:Analysis of the age distribution of cancers of the uterus reveals three clearly distinctive types: early- and late-onset cancers of the cervix and one form of cancer of the corpus. England and Wales mortality data are available for the three types combined from 1911; cancers of the cervix and corpus have been listed s...

journal_title：Medical hypotheses

authors： Burch PR

更新日期：1986-05-01 00:00:00

abstract：:In elderly, the fractures in C1-C2 are a common entity. Poor bone quality and wide range of motion hamper the natural bone fusion, thus making surgery often the only possible way to deal with the underlying pathology. The proximity to important neurovascular structures represents the stabilization in this segment a ch...

journal_title：Medical hypotheses

authors： Pavlov O,Mirchev N,Behr R

更新日期：2020-02-21 00:00:00

abstract：:Several hypotheses have been developed to interpret the progression of tubulointerstitial fibrosis (TF), including senescence, epithelial-mesenchymal transition, inflammation, chronic hypoxia, and reactive oxygen species. All of these hypotheses are based on persistent cell injury and localized cell death. Proliferati...

journal_title：Medical hypotheses

authors： Chen BC,Bai YH,Tang LL,Wang BQ,Liu B,Cai Y,Peng X,Yang YR,Zheng SL

更新日期：2014-06-01 00:00:00

abstract：:Metformin, a drug widely used in the treatment of type II diabetes mellitus (T2DM), has been the focus of interest as a potential therapeutic agent for certain types of malignancies, including gynaecological cancers [i.e. endometrial cancer (EC)]. Although the exact mechanism behind the potential anticancer activity o...

journal_title：Medical hypotheses

authors： Karadeniz Z,Aynacıoğlu AŞ,Bilir A,Tuna MY

更新日期：2020-01-01 00:00:00

abstract：:S-allylgutimine has immunostimulant and tumor cell inhibitory activities. This complex action may be a result of the stimulation of IL-2 production. The effectiveness of immunotherapy depends on the uncoupling of IL-2 downregulation. This principle can be widely used with those immunological diseases where IL-2 level ...

journal_title：Medical hypotheses

authors： Vértesi C

更新日期：1993-06-01 00:00:00

abstract：:Endemic cancer of the oesophagus in Africa is associated with the use of maize as the staple. In one African community endemic cancer of the oesophagus has been shown to have a strong statistical association with the consumption of foods based on maize in the meal form. A strong association with consumption of maize m...

journal_title：Medical hypotheses

authors： Sammon AM,Iputo JE

更新日期：2006-01-01 00:00:00

abstract：:TP53 (Tumor Protein 53, previously known as p53) is probably the best known of all tumor suppressor genes, and is mutated in nearly all (96%) high-grade serous ovarian cancer (HGS-OvCa), which is the most common histopathological type of epithelial ovarian cancer (EOC). Recently, TP53 is found to involve in regulating...

journal_title：Medical hypotheses

authors： Hu J,Liu Z,Wang X

更新日期：2013-10-01 00:00:00

abstract：:The pancreatic leakage is a lethal postoperative complication to the patients after duodenopancreatectomy for carcinoma of head of pancreas. However, we found that the patients who survived this lethal postoperative complication could potentially acquire a longer survival time comparing with those without postoperativ...

journal_title：Medical hypotheses

authors： Liu H,Liu M,Yuan T,Tang C,Chen P

更新日期：2009-08-01 00:00:00

abstract：:The cumulative incidence of uterine leiomyoma at age 50 is ≈ 70% in White women and >80% in Black women. Although risk factor research is limited, increasing age, and being premenopausal, nulliparous or Black are risk factors for leiomyomas. Black women tend to have larger leiomyomas and be younger at diagnosis. Surpr...

journal_title：Medical hypotheses

authors： Wegienka G

更新日期：2012-08-01 00:00:00

abstract：:We have formalized extracellular and intracellular volume interaction with each other and the influence of these processes on the type of cell growth. The linearized model was verified by stereo metric solution and the results were compared with experimental data. Two theoretical solutions were found: Solution 1, extr...

journal_title：Medical hypotheses

authors： Hajek D,Kolar P,Maini PK,Starha P

更新日期：2005-01-01 00:00:00

abstract：:Foster found areas with the highest incidence of SIDS in USA in 1983-1984 coincided with the highest areas recorded with the highest incidence of goitre in First World War troops (1). Reid compared the two populations described as having the highest incidence of SIDS worldwide. Both were selenium deficient areas (King...

journal_title：Medical hypotheses

authors： Reid G,Tervit H

更新日期：1994-04-01 00:00:00

abstract：:The recent global pandemic created by the Coronavirus SARS-CoV-2, started in Wuhan, China in December 2019, has generated panic, both in term of human death (4-5% of infected patients identified through testing) and the global economy. Human sufferings seem to be continuing, and it is not clear how long this will cont...

journal_title：Medical hypotheses

authors： Ahmad SI

更新日期：2020-09-01 00:00:00

abstract：:In literature, the cerebellum is given a substantial role in cognitive processes, in addition to traditional views on cerebellar function of regulating motor behaviour. The phenomenon of cerebellar damage causing impairments in memory and executive functioning was observed in various cerebellar disorders. Cerebellar c...

journal_title：Medical hypotheses

authors： Wijnia JW,Goossensen A

更新日期：2010-08-01 00:00:00

abstract：:Severe affective and behavioral dysregulation, labeled as severe mood dysregulation (SMD), is a widely spread phenomenon among adolescent psychiatric patients. This phenotype constitutes severe impairment across multiple settings, including various symptoms, such as non-episodic anger, mood instability, and hyperarous...

journal_title：Medical hypotheses

authors： Heiler S,Legenbauer T,Bogen T,Jensch T,Holtmann M

更新日期：2011-10-01 00:00:00

abstract：:Deciding for an amputation in case of complex regional pain syndrome type I (CRPS-I) is controversial. Evidence for favorable or adverse effects of an amputation is weak. We therefore follow a careful and well-structured decision making process. After referral of the patient with the request to amputate the affected l...

journal_title：Medical hypotheses

authors： Schrier E,Dijkstra PU,Zeebregts CJ,Wolff AP,Geertzen JHB

更新日期：2018-12-01 00:00:00

abstract：:Stressful events occur in the lives of millions of individuals each year. Such events, or "stressors", are experiences that threaten personal well-being, and include traumatic events such as motor vehicle collision, infectious illness, and situations such as military deployment. While most individuals recover from suc...

journal_title：Medical hypotheses

authors： McLean SA,Clauw DJ

更新日期：2004-01-01 00:00:00

abstract：:Cancer cells proliferate and metastasize against the body's defense mechanisms due to their ability to change in response to challenges, both from the body's internal defenses as well as those from external sources, such as radiation and chemotherapy. This ability of tumor cell populations to change and grow in respon...

journal_title：Medical hypotheses

authors： Pienta KJ,Ward WS

更新日期：1994-01-01 00:00:00

abstract：:Preeclampsia (PE) and gestational diabetes mellitus (GDM) are two of the most common medical complications of pregnancy, with risks for both mother and child. Like many other antepartum complications, PE and GDM occur only in pregnancy. However, it is not clear if pregnancy itself is the cause of these complications o...

journal_title：Medical hypotheses

authors： Wen SW,Xie RH,Tan H,Walker MC,Smith GN,Retnakaran R

更新日期：2012-07-01 00:00:00