Abstract：
:Metastases from unknown primary tumours (MUP) are not an uncommon clinical problem. A hypothesis that discusses the plausible role of neoangiogenesis, as a central theme in the development of MUPs, is presented. Invasive cancers, which cannot or do not switch to the angiogenic phenotype, remain subclinical. In situations where a non-angiogenic tumour attempts to grow beyond the volume that can be supported by the vasculature, marked apoptosis and cell turnover result. Tumours with a high cell turnover are biologically advanced. Thus, such subclinical tumours acquire a metastatic phenotype. In the viscera, metastases may remain dormant for varying periods until subclones with an angiogenic phenotype arise due to tumour evolution or they burn out. Visceral MUPs, due to their longer evolution, are biologically advanced and have dismal prognosis. Contrary to this, tumour cells reaching lymph nodes (LN) grow without acquiring any phenotypic or genotypic change, as angiogenesis is redundant for growth within the metastatic LNs.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Naresh KNdoi
10.1016/s0306-9877(02)00221-9keywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
357-60issue
3eissn
0306-9877issn
1532-2777pii
S0306987702002219journal_volume
59pub_type
杂志文章abstract：:Hyperplasia of the coronoid process of the mandible has been observed in conditions like Oral submucous fibrosis, TMJ ankylosis, etc. The etiopathogenesis of this coronoid overgrowth has not been clearly sequenced or adequately hypothesized, and no definite mechanism has so far been advocated to explain this elongatio...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.07.058
更新日期：2011-11-01 00:00:00
abstract：:There are different theories and hypotheses related to the aetiology of depression. The interaction between brain 5-HT level and the activity of its autoreceptors plays a role in mood changes and depression. In major depression, activation of the inflammatory response system (IRS) and, increased concentrations of proi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00207-x
更新日期：2003-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
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更新日期：2004-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2002-12-01 00:00:00
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.06.030
更新日期：2005-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2005-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(91)90242-q
更新日期：1991-07-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.04.018
更新日期：2017-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.08.032
更新日期：2006-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2000.1089
更新日期：2000-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2014.06.017
更新日期：2014-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.09.004
更新日期：2017-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0306-9877(94)90160-0
更新日期：1994-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.0878
更新日期：2000-03-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00182-8
更新日期：2003-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.07.024
更新日期：2012-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2005-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2020-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.02.019
更新日期：2007-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/S0306-9877(03)00308-6
更新日期：2004-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：1993-11-01 00:00:00
abstract：:Osteoarthritis (OA) is a chronic, degenerative disorder of multifactorial aetiology, characterized by loss of articular cartilage and periarticular bone remodelling. Goals of managing OA include controlling pain, maintaining and improving function and health-related quality of life, and limiting functional impairment....
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.01.084
更新日期：2007-01-01 00:00:00
