Cannabinoid hyperemesis syndrome: A disorder of the HPA axis and sympathetic nervous system?

abstract：:This article reviews the biochemical and physiological observations underpinning the synergism between ghrelin and ghrelin agonists with exercise, especially progressive resistance training that has been shown to increase muscle mass. The synergy of ghrelin agonists and physical exercise could be beneficial in conditi...

journal_title：Medical hypotheses

authors： Fuoco D,Kilgour RD,Vigano A

更新日期：2015-12-01 00:00:00

abstract：:Intestinal dysbiosis refers to an imbalance in the intestinal flora. The concept of small intestinal bacterial overgrowth (SIBO), a condition of abnormal proliferation of the small intestine microbiota, has been proposed as a form of small intestine dysbiosis. In Parkinson's disease patients, weight loss and metabolic...

journal_title：Medical hypotheses

authors： Hasuike Y,Endo T,Koroyasu M,Matsui M,Mori C,Yamadera M,Fujimura H,Sakoda S

更新日期：2020-01-01 00:00:00

abstract：:Fibromyalgia (FM) is a debilitating, widespread pain disorder that is assumed to originate from inappropriate pain processing in the central nervous system. Psychological and behavioral factors are both believed to underlie the pathogenesis and complicate the treatment. This hypothesis, however, has not yet been suffi...

journal_title：Medical hypotheses

authors： Hulens M,Dankaerts W,Stalmans I,Somers A,Vansant G,Rasschaert R,Bruyninckx F

更新日期：2018-01-01 00:00:00

abstract：:Herbs and minerals are the integral parts of traditional systems of medicine in many countries. Kushta is a form of herbo-mineral preparations used in traditional systems of medicine (Unani and Ayurvedic) of Indo-Pak subcontinent. These preparations have long been used and claimed to be the most effective and potent d...

journal_title：Medical hypotheses

authors： Aziz N,Gilani AH,Rindh MA

更新日期：2002-10-01 00:00:00

abstract：:We tested the hypothesis that if SPECT/CT-detected volumes of active and inactive parts of brain tissue present correlation with the results of hyperbaric oxygen therapy (HBOT) of ischemic stroke, SPECT imaging may serve as a selective tool for post-stroke patients to indicate cases that may significantly benefit from...

journal_title：Medical hypotheses

authors： Golan H,Makogon B,Volkov O,Smolyakov Y,Hadanny A,Efrati S

更新日期：2020-03-01 00:00:00

abstract：:Timely recanalization of infarct related artery along with effective myocardial cell reperfusion represents a major challenge in the management of STEMI. The reperfusion of coronary arteries can induce further cardiomyocyte death by generating oxidative stress, which itself can mediate myocardial damage through a numb...

journal_title：Medical hypotheses

authors： Truscelli G,Tanzilli G,Viceconte N,Dominici M,Arrivi A,Sommariva L,Granatelli A,Gaudio C,Mangieri E

更新日期：2017-05-01 00:00:00

abstract：:The etiology of most kinds of dementia is still obscure and is probably multifactorial. We query whether excessive watching of television may contribute to the development of dementive processes for the following reasons: TV spectators are exposed to a mass of successive and rapid stimuli with little or no possibility...

journal_title：Medical hypotheses

authors： Aronson M

更新日期：1993-11-01 00:00:00

abstract：:Melanoma is one of the most aggressive cancers which has very low response rate and survival rate. Melanoma cells are known to be inherently resistant to the chemotherapy which results in poor outcomes and even failure of the therapy. For this reason, a better understanding of underlying mechanism of melanoma pathogen...

journal_title：Medical hypotheses

authors： Mishra H,Mishra PK,Ekielski A,Iqbal Z,Jaggi M,Talegaonkar S

更新日期：2018-07-01 00:00:00

abstract：:'Electrohypersensitivity' is often explained as a psychological syndrome. Our modern environment contains a lot of different substances and some of them are toxic. Mycotoxins are types of toxins that are biologically very active and that affect living organisms. Mycotoxins and fungi capable of producing toxins have be...

journal_title：Medical hypotheses

authors： Anttila K

更新日期：2000-09-01 00:00:00

abstract：:Epoxides as reactive intermediates of estrogen metabolism have been considered to be potential precursors of the 2- and 4-hydroxy, catechol estrogens and even to be mutagenic/carcinogenic agents themselves. The labile nature of the intermediates has made proof of their existence difficult in natural biological conditi...

journal_title：Medical hypotheses

authors： Raeside JI

更新日期：2016-06-01 00:00:00

abstract：:Traumatic iris sphincter tear has been thought to occur secondary to anteroposterior compression of the globe with defined forces lead to equatorial expansion and active pull along the corneoscleral junction and sphincter tear. However, here in this report, we elaborate the additional forces involved in the traumatic ...

journal_title：Medical hypotheses

authors： Pujari A,Agarwal D,Kumar Behera A,Bhaskaran K,Sharma N

更新日期：2019-01-01 00:00:00

abstract：:In a recent issue of Medical Hypotheses, Dr H L Newbold repeats the assertion that the cause of James B Duke's death in 1925 was pernicious anemia. Dr Newbold postulates that Mr Duke was neurologically impaired as a result of vitamin B-12 deficiency and that he suffered from depression. In an attempt to relieve this d...

journal_title：Medical hypotheses

authors： Halperin EC

更新日期：1991-11-01 00:00:00

abstract：:It is suggested here that a Hemoglobin S (HbS)-mediated membrane oxidant injury is responsible for both the protection from malaria infection in the heterozygous sickle cell state, and for a critical pathologic process in homozygous sickle cell disease. This suggestion is arrived at by applying to the HbS condition th...

journal_title：Medical hypotheses

authors： Anastasi J

更新日期：1984-07-01 00:00:00

abstract：:Skin photoaging, the most common skin damage, is caused by chronic UV irradiation. It is involved in the reduction, aging and apoptosis of fibroblasts (FBs) as well as the blockage of transforming growth factor-beta (TGF-β)/Smad and p38 mitogen-actived protein kinase (MAPK) signaling pathways. Dermal multipotent stem ...

journal_title：Medical hypotheses

authors： Zhong J,Hu N,Xiong X,Lei Q,Li L

更新日期：2011-03-01 00:00:00

abstract：:Chlorination of potable water supplies high in organics may yield carcinogenic compounds such as trihalomethanes. Chlorine dioxide has been proposed as an alternative disinfectant to chlorine. However, chlorine dioxide is a strong oxidant that forms significant amounts of chlorite when added to potable water supplies,...

journal_title：Medical hypotheses

authors： Moore GS,Calabrese EJ,DiNardi SR,Tuthill RW

更新日期：1978-09-01 00:00:00

abstract：:In this study, after having formed the hypothesis of the existence of a "Compensating Center" (cerebral?) that orders the increase in the function of one kidney in case of deterioration of its congener, we propose two mechanisms that may lead to the activation of this Center. The first may be the difference between th...

journal_title：Medical hypotheses

authors： Collard M

更新日期：1988-03-01 00:00:00

abstract：:In a previous paper we predicted that health effects of dietary fats in humans would require half a century or more to be understood, instead of the decade or so predicted during 1956 by an Editorial in The Lancet. It would seem that our prediction may have been optimistic since it has now been reported that trans uns...

journal_title：Medical hypotheses

authors： Booyens J,van der Merwe CF

更新日期：1992-04-01 00:00:00

abstract：:The mechanism by which polyglutamine expansions in several proteins lead to neurodegenerative disorders remains largely unknown. The biochemical properties of polyglutamine repeats suggest one possible explanation; endolytic cleavage at a glutaminyl-glutaminyl bond followed by pyroglutamate formation may contribute to...

journal_title：Medical hypotheses

authors： Saido TC

更新日期：2000-03-01 00:00:00

abstract：:It has been proposed that combination of indole-3-acetic acid (IAA) and horseradish peroxidase (HRP) could be useful as the basis for targeted cancer therapy involving antibody-, polymer-, or gene-directed approaches. By circulating IAA in human body, the cells labeled with HRP could be selectively killed since cytoto...

journal_title：Medical hypotheses

authors： Kawano T

更新日期：2003-05-01 00:00:00

abstract：:Although once considered by biologists almost exclusively for their toxicity, reactive oxygen (ROS) and nitrogen (RNS) species produced within normal cells under baseline physiological conditions are now appreciated as redox regulators of a wide range of protein functions. Two families of enzymes, the NADPH oxidases (...

journal_title：Medical hypotheses

authors： Stuart JA,Aibueku O,Bagshaw O,Moradi F

更新日期：2019-08-01 00:00:00

abstract：:Restless legs syndrome (RLS) exhibits sensorimotor symptoms. In familial cases, a gene at chromosomal location 9p-24-22 is linked to RLS and the expressed mutation is Dopamine Receptor Specific Individual Sensitivity (DRSIS). The symptoms are triggered during changes in alertness, generally at sleep hours, resulting f...

journal_title：Medical hypotheses

authors： Akpinar S

更新日期：2009-08-01 00:00:00

abstract：:There have been various comments on the complexity of cell signaling and the need for simplification. Recently, new mechanics was proposed by Hlavacek and Faeder as a means of achieving this goal. Some of the important tenets include: (1) phosphorylation of nearby phosphorylation sites is likely to be cooperative and ...

journal_title：Medical hypotheses

authors： Kovacic P

更新日期：2010-05-01 00:00:00

abstract：:Scrub typhus is a mite borne infectious disease which has re-emerged in India in the 3rd millennium after years of quiescence. In this review, the authors hypothesize the various factors responsible for resurgence of this disease. The main drivers that could have contributed to the upsurge in scrub typhus cases in pas...

journal_title：Medical hypotheses

authors： Ranjan J,Prakash JAJ

更新日期：2018-06-01 00:00:00

abstract：:For almost 70 years, essential fatty acid deficiency has been known to be associated with skin disorders, vessel abnormalities, and increased tumorigenesis. However, the underlying molecular and cellular mechanism is largely unknown. Recently, it has been reported that essential fatty acids regulate cell adhesion by m...

journal_title：Medical hypotheses

authors： Jiang WG,Eynard AR,Mansel RE

更新日期：2000-09-01 00:00:00

abstract：:The exact nature of the mechanism that triggers initiation of chromosome replication in the best understood of all organisms, Escherichia coli, remains mysterious. Here, I suggest that this mechanism evolved in response to the problems that arise if chromosome replication does not occur. E. coli is now known to be hig...

journal_title：Medical hypotheses

authors： Norris V

更新日期：2011-05-01 00:00:00

abstract：:Although Still's disease has been first described more than one century ago, it still appears as an orphan entity, which should be separated from the other auto-inflammatory diseases (AID). The main reason to individualize Still's disease among the AID is the absence of any genetic predisposition. Recently, the human ...

journal_title：Medical hypotheses

authors： Hayem F,Hayem G

更新日期：2012-08-01 00:00:00

abstract：:Alzheimer's disease (AD) may be related to nutritional deficiencies from exocrine pancreatic insufficiency (EPI) with mal-absorption of essential nutrients, vitamins and minerals. EPI occurs in about twenty percent of the elderly population, sometimes without obvious symptoms, a number similar to the incidence of AD. ...

journal_title：Medical hypotheses

authors： Brenner SR

更新日期：2017-05-01 00:00:00

abstract：:Advances in human genome analyses have not yet allowed identification of specific genetic mechanisms underlying the expression of human neurobehavioural disorders. There is an increasing awareness that several genes may contribute to behavioural phenotypes and these genes appear to interact in as yet undetermined ways...

journal_title：Medical hypotheses

authors： Gericke GS

更新日期：2006-01-01 00:00:00

abstract：:Natural whole foods contain fats as structural components, and have a balance of polyunsaturated fat, monounsaturated fat, and saturated fat. Since we are still a Paleolithic species, adapted to eating only wild foods, it is difficult to justify the consumption of anything other than an overall balance of triglyceride...

journal_title：Medical hypotheses

authors： Broadhurst CL

更新日期：1997-09-01 00:00:00

abstract：:The objective of this study was to test the hypothesis that the regular practice of mindfulness meditation is associated with increased physiological levels of melatonin. Melatonin may be related to a variety of biologic functions important in maintaining health and preventing disease, including breast and prostate ca...

journal_title：Medical hypotheses

authors： Massion AO,Teas J,Hebert JR,Wertheimer MD,Kabat-Zinn J

更新日期：1995-01-01 00:00:00