Abstract：
:In a recent issue of Medical Hypotheses, Dr H L Newbold repeats the assertion that the cause of James B Duke's death in 1925 was pernicious anemia. Dr Newbold postulates that Mr Duke was neurologically impaired as a result of vitamin B-12 deficiency and that he suffered from depression. In an attempt to relieve this depression, Dr Newbold argues that James B Duke donated the money necessary to found Duke University. Had he been properly treated for pernicious anemia, James Duke might have not been depressed nor made his donation. The historical record does not substantiate this hypothesis. Dr George Minot, Novel Laureate for his work on pernicious anemia, was a consultant to Mr Duke's physicians, and felt that the patient did not have pernicious anemia. There is no independently verifiable evidence to demonstrate that Mr Duke ever suffered from depression. Duke made his first donations to Trinity College, later named Duke University, in 1900--25 years before his death. The available data discounts the hypothesis that depression related to pernicious anemia played any role in the founding of Duke University.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Halperin ECdoi
10.1016/0306-9877(91)90130-qsubject
Has Abstractpub_date
1991-11-01 00:00:00pages
200-3issue
3eissn
0306-9877issn
1532-2777pii
0306-9877(91)90130-Qjournal_volume
36pub_type
传,历史文章,杂志文章abstract：:Preliminary but increasing evidence suggests that attention-deficit/hyperactivity disorder (ADHD), Tourette's syndrome (TS), and restless legs syndrome (RLS) may be comorbid. In the present article, we hypothesize that ADHD, TS, and RLS may be part of a spectrum, and that iron deficiency contributes to the pathophysio...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.10.013
更新日期：2008-01-01 00:00:00
abstract：:The endotheliopathy associated with insulin resistance syndrome appears to result largely from excessive free fatty acid (FFA) exposure that boosts endothelial production of diacylglycerol, thereby activating protein kinase C. This endothelial "lipotoxicity" can be alleviated by very-low-fat diets and by appropriate w...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.01.042
更新日期：2005-01-01 00:00:00
abstract：:Preeclampsia (PE) and gestational diabetes mellitus (GDM) are two of the most common medical complications of pregnancy, with risks for both mother and child. Like many other antepartum complications, PE and GDM occur only in pregnancy. However, it is not clear if pregnancy itself is the cause of these complications o...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.04.019
更新日期：2012-07-01 00:00:00
abstract：:A comparison is made of the x-ray induced thyroid adenocarcinoma in the rat by the in-vitro, in-vivo method of Clifton et al. with previous data of Doniach on in-vivo irradiation in whole animals. The Clifton data consists of only one point at 500 rad. I have assumed that the probability of transformation per viable c...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(84)90070-7
更新日期：1984-04-01 00:00:00
abstract：:Boron is increasingly added to food supplements due to multiple effects that have been reported in mammals after boric acid administration. Among these effects are inflammatory process control, bone and muscle strength enhancement, protein expression regulation, and a decreased risk of developing some pathologies in w...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.06.024
更新日期：2018-09-01 00:00:00
abstract：:Exercise is thought to have considerable potential as a preventive for osteoporosis. We critically examined 27 studies that address the prophylactic role of exercise in osteoporosis. The results from both cross-sectional and longitudinal studies showed that differences in bone mass were more pronounced in the axial sk...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/0306-9877(89)90118-7
更新日期：1989-09-01 00:00:00
abstract：:Exacerbation of certain medical conditions during specific phases of the menstrual cycle has long been recognized. Mechanisms of the cyclic variations are poorly understood, but are often attributed to fluctuations in reproductive hormones. We hypothesize that normal variations in autonomic balance during the menstrua...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.02.036
更新日期：2004-01-01 00:00:00
abstract：:Ischaemic stroke ranks among the most important causes of death and disability in developed countries. Abnormal lipid metabolism is among the several factors that have a role in the pathogenesis of atherosclerosis. We hypothesize that the decreased resistance of low-density lipoproteins against oxidative stress is an ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2000.1252
更新日期：2001-06-01 00:00:00
abstract：:In the AKR strain of mice a high incidence of spontaneous lymphoid leukemia develops before 12 months of age. Genetic, viral, and endocrine factors interact during development to produce the syndrome. Many of the deficiencies of AKR mice are associated with gene action in chromosome 17, at or near the major histocompa...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(76)80005-9
更新日期：1976-11-01 00:00:00
abstract：:A hypothesis is presented concerning the origin of the action of muscles in the human and animal bodies It is advanced that muscle action originates with very rapid chemical reactions known as percussion reactions. These give rise to the temporary precipitation of solids in muscle cells. The accompanying volume change...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00149-4
更新日期：2002-08-01 00:00:00
abstract：:It is suggested that the Persian Gulf Syndrome (PGS) is caused by beef allergy. In the first symptomless phase, as a result of an energetic US Army immunizing program, using sera with adjuvants to produce detectable antibody levels, the subjects not only developed immunity to the targeted substances, but also became s...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(95)90106-x
更新日期：1995-09-01 00:00:00
abstract：:From biographical data sources on ranking scientists, I was able to identify 35 centenarians. Among these, only one (Michel Chevereul from France) lived before the 20th century. Since the remaining 34 individuals became centenarians only from 1965, I propose that centenarian scientists are an unusual cluster, first fo...
journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
doi：10.1054/mehy.2001.1480
更新日期：2001-12-01 00:00:00
abstract：:Stressful events occur in the lives of millions of individuals each year. Such events, or "stressors", are experiences that threaten personal well-being, and include traumatic events such as motor vehicle collision, infectious illness, and situations such as military deployment. While most individuals recover from suc...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.03.022
更新日期：2004-01-01 00:00:00
abstract：:Helical bundles are found in all the known structures of peanut allergens. The peptide fragments, which survive gastrointestinal digestion of the allergens and are absorbed intact, are hypothesized to reassociate and form stable helical bundles in the circulation, which could elicit a specific IgE response resulting i...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.07.024
更新日期：2012-11-01 00:00:00
abstract：:Since 1960, the incidence of melanoma has increased dramatically in Caucasians worldwide, and during the past decade has risen at a rate of 6% a year in the USA. A hypothesis regarding this increased incidence suggests that the prevalent use of antibacterial soaps that contain photosensitizing compounds may be a risk ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1997.0718
更新日期：1999-07-01 00:00:00
abstract：:The limb remote ischaemia postconditioning (RIPOC), a newly conceived idea of applying brief limb ischaemic stimulus after onset of the myocardial ischaemia but prior to the reperfusion, can offer the possibility of applying this cardioprotective strategy to the patients with acute myocardial infraction. Although incr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.04.004
更新日期：2009-09-01 00:00:00
abstract：:The assumption is introduced that there are two types of adaptive responses in central neurons in response to significantly changed circuit activity. Morphological synaptic modifications and synapse turnover are thought to be involved in both of these responses, in such a way that in the first case they are to restore...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(91)90077-c
更新日期：1991-05-01 00:00:00
abstract：:Neural tube defect (NTD) is more common among spontaneously aborted fetuses than in infants born in the third trimester, but there is no direct evidence that NTD-affected conceptuses, presenting at these two different gestational ages, are components of a single disease process. Evidence for homology is here presented...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(79)90129-4
更新日期：1979-02-01 00:00:00
abstract：:Medical Hypotheses exists to give ideas and speculations in medicine a fair hearing. Doing this is not easy. Most conventional journals would regard some of what is published here as questionable, most referees would reject it as 'unproven'. We have more liberal standards, for reasons we have presented before. But we ...
journal_title：Medical hypotheses
pub_type： 社论
doi：10.1016/j.mehy.2004.10.003
更新日期：2005-01-01 00:00:00
abstract：:It has been proposed that combination of indole-3-acetic acid (IAA) and horseradish peroxidase (HRP) could be useful as the basis for targeted cancer therapy involving antibody-, polymer-, or gene-directed approaches. By circulating IAA in human body, the cells labeled with HRP could be selectively killed since cytoto...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00012-4
更新日期：2003-05-01 00:00:00
abstract：:Logic, a fundamental component of research in the exact sciences is often not applied in prominent fields of medical research. Investigation into the aetiopathogenesis of headache, vertigo, and fatigue--acknowledged as the commonest and amongst the most prominent and debilitating of symptoms known to mankind--may be s...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(90)90025-a
更新日期：1990-04-01 00:00:00
abstract：:It is well known that chronic hepatitis C is associated with insulin resistance and metabolic syndrome which are risk factors for atherosclerosis and coronary heart disease. As a result, chronic hepatitis C might be thought, through its association with metabolic syndrome, to increase the risk of myocardial infarction...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2014.01.030
更新日期：2014-04-01 00:00:00
abstract：:Neurofibromatosis 1 is a common heritable disorder. The gene causing neurofibromatosis 1 had been recognized and the protein encoded by this gene, neurofibromin, was supposed to play a role in development of various tissues. Neurofibromin was found to have GTP-ase (GAP) domain against small p21 ras. IQGAP1 is another ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2000.1232
更新日期：2001-03-01 00:00:00
abstract：:Almost all solid tumors consist of aneuploid cells with highly abnormal chromosome numbers. Such cancer cells could very well originate from chromosome missegregation which is a disturbingly common phenomenon, happening in 0.01 to 4 percent of cell divisions. Missegregated cells are aneuploid, typically lacking a chro...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.08.028
更新日期：2018-11-01 00:00:00
abstract：:Deep brain stimulation of the pedunculopontine tegmental nucleus (PPTg) had usually been reported to improve the symptoms of advanced Parkinson's disease. Previous studies showed that neurons in the PPTg involved in the control of the sympathetic outflow to the kidneys. Our recent studies using transneuronal labeling ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.09.022
更新日期：2011-12-01 00:00:00
abstract：:The Aquatic Ape Theory claims that human ancestors once lived in a semi-aquatic habitat. Some human diseases might be explained by our aquatic past. Such problems include hyperventilation, periodic breathing, laryngo- and bronchospasm, vasomotor rhinopathy, seborrhea, dandruff, male pattern alopecia, rhinophyma, osteo...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(87)90076-4
更新日期：1987-11-01 00:00:00
abstract：:Psammoma bodies are structures classified in the group of dystrophic calcifications, which occur in some kind of tumors and in choroid plexus during the aging process. Despite early discovery of their presence in choroid plexus stroma, mechanisms responsible for their formation remained unclear. Their presence in some...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.01.006
更新日期：2010-06-01 00:00:00
abstract：:It is generally accepted that a placebo in a standard, randomized, controlled trial (RCT), being an inert substance, cannot itself produce any effects. Yet, the magnitude of the placebo effect has increased remarkably in the last three decades. We propose that macroscopic information entanglement potentially explains ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.06.047
更新日期：2011-10-01 00:00:00
abstract：:Six medical papyri document how Santorini's volcanic ash from the Bronze Age biphasic eruption, otherwise attested by material retrieved at the bottom of lakes at the edge of the Nile Delta, severely affected the health of the inhabitants of Egypt as well as their society as a whole. Treatments for burns caused by par...
journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
doi：10.1016/j.mehy.2006.01.008
更新日期：2006-01-01 00:00:00
abstract：:All kinds of hypotheses have been proposed to explain the mechanism of tumorigenesis. Up until now, we have not had any generally acknowledged model that helps us understand the process. In this paper, I propose a dynamic model of how tumor cells escape the supervision of the immune system; I also examine the possibil...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(95)90256-2
更新日期：1995-05-01 00:00:00
