Abstract：
:Melanoma is one of the most aggressive cancers which has very low response rate and survival rate. Melanoma cells are known to be inherently resistant to the chemotherapy which results in poor outcomes and even failure of the therapy. For this reason, a better understanding of underlying mechanism of melanoma pathogenesis and resistance is required, so that more efficient and novel therapeutic strategies can be developed. Survivin is a protein which is overexpressed in melanoma cells and is known to impart resistance to them against apoptosis. Also, melanoma cells overexpress Vascular Endothelial Growth Factor (VEGF) and basic Fibroblast Growth Factor (bFGF) angiogenic growth factors which lead to aggressive angiogenesis in melanoma cells thereby making the treatment more challenging. This hypothesis presents a combinatorial approach against melanoma where an anti-survivin agent and an anti-angiogenic agent are combined with a chemotherapeutic drug and loaded in surface functionalized liposomes in order to target specific mechanisms of melanoma, thus overcoming its resistance. Thus, the study aims to overcome the resistance of melanoma cells by developing a wise combination of drugs and achieve a higher response rate in resistant melanoma model, which is usually not achieved with the existing treatment modalities.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Mishra H,Mishra PK,Ekielski A,Iqbal Z,Jaggi M,Talegaonkar Sdoi
10.1016/j.mehy.2018.05.002subject
Has Abstractpub_date
2018-07-01 00:00:00pages
141-146eissn
0306-9877issn
1532-2777pii
S0306-9877(18)30151-8journal_volume
116pub_type
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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journal_title：Medical hypotheses
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pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
pub_type： 杂志文章
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