Abstract：
:The autoimmune disease rheumatoid arthritis (RA) presents difficulty in diagnosis, commonly observed flare ups, polycyclical nature of RA progression, and variable response to therapies. Congruent with multiple causes, literature has documented various infectious agents, environmental factors, physical trauma, silica and food sensitivities as potential causes of RA or RA flares in different populations. We propose that these>36 events can initiate RA or RA flares which complicates treatment decisions. Each pharmaceutical medicine benefits 15-82% of RA patients. Predictive factors are needed. Because the initiating cause of RA or RA flare affects the type of joint damage, initial inflammatory response, adaptive immune response, and potential molecular mimicry, we propose the "RA cause affects response to therapy" (RACART) theory. The potential cause combined with confounding factors such as genetic risk factors, nutritional status, epigenetic status, inflammatory levels, and detoxification ability may help predict responses to various therapies.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Molnar-Kimber KL,Kimber CTdoi
10.1016/j.mehy.2011.10.006subject
Has Abstractpub_date
2012-01-01 00:00:00pages
123-9issue
1eissn
0306-9877issn
1532-2777pii
S0306-9877(11)00520-2journal_volume
78pub_type
杂志文章abstract：:A possible mechanism for maintaining immune memory, based on idiotypic-anti-idiotypic interactions, is described. It is proposed that pendular dynamic swings in the levels of idiotypic antibodies (Ab1) and anti-idiotypic Ab2 may underlay immune memory. In the terms of the advanced concept, Ab dynamics in the maternal ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2000.1132
更新日期：2001-02-01 00:00:00
abstract：:Sperm production is regulated by inhibin. Inhibin secretion may be controlled by the number of ejaculations. The more the number of ejaculations, the less the inhibin in blood and the more the production of spermatozoa. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(89)90089-3
更新日期：1989-10-01 00:00:00
abstract：:The physical interaction between the red blood cells and colloidal silica leads to hemolysis. We propose that the nature of the red-cell elimination as the result of this interaction is not random. As the negatively charged silica particles at the physiological conditions electrostatically react with the positive site...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(96)90046-8
更新日期：1996-07-01 00:00:00
abstract：:Plantar fasciitis has been and remains one of the most common pathologic conditions of the lower extremity. Patients diagnosed with plantar fasciitis are treated conservatively with various degrees of success. This article presents a review of the literature pertaining to treatment of plantar fasciitis as well as intr...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/s0306-9877(02)00120-2
更新日期：2002-07-01 00:00:00
abstract：:The time of re-evaluation of the role of human immunodeficiency viruses in the pathogenesis of acquired immune deficiency syndrome has now come, now that methods are available for the direct detection of human immunodeficiency viruses and for the detection of cellular anti-human immunodeficiency virus immune reactions...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(96)90192-9
更新日期：1996-04-01 00:00:00
abstract：:Cancer is a tissue that requires a genetic program, possibly involving hundreds of genes, as indicated by studies of differential gene expression performed with microarrays in various types of cancer. Cancer is thus a biological process of considerable precision as described by Schrödinger's equation, and it is not si...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.11.033
更新日期：2009-04-01 00:00:00
abstract：:This hypothesis clearly proposes the true and previously undiscovered cause of male homosexuality or bisexuality and in most cases the predictability in infancy of the development of this sexuality in adulthood. It is based on compelling new evidence which has accumulated over many years. The fetal and neonatal period...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.06.006
更新日期：2016-09-01 00:00:00
abstract：:Positive cancer patient outcomes, including increased time to recurrent events, have been associated with increased counts and function of natural killer (NK) cells. NK cell counts and function are elevated following acute exercise, and the generally accepted mechanism of increased recruitment suggests that binding of...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.10.015
更新日期：2017-11-01 00:00:00
abstract：:Although peripartum cardiomyopathy (PPCM) is a rare disease, it has very serious consequences for both mother and child. No single cause has been held responsible for the pathogenesis. Recent studies have indicated that increased proteolytic cathepsin D activity in cardiomyocytes results in16kDa prolactin fragments wi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.08.029
更新日期：2010-02-01 00:00:00
abstract：:The theory presented herewith provides a unified explanation for neoplasia and teratogenesis, both regarded here as stem cell disorders. Proliferating cells in the organism form two mutually exclusive classes, immortal stem cells and transitional cells whose life span is limited. Any lasting change in the organism e.g...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(85)90013-1
更新日期：1985-03-01 00:00:00
abstract：:Dental caries, a bacterial process that results in the acidic destruction of tooth structure, has historically been managed by the mechanical excavation of diseased tooth structure and then restoration with a synthetic material. The mechanical excavation of the infected site is most commonly achieved by a dental handp...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.05.002
更新日期：2011-09-01 00:00:00
abstract：:Hypertension is the leading cause of cardiovascular diseases, and an estimated 972 million people in the world are suffering from this problem. Indubitably, hypertension is an important worldwide public-health challenge. In recent years many efforts have been made to devise novel therapies involving new targets implic...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.03.030
更新日期：2009-09-01 00:00:00
abstract：:Alzheimer's disease (AD) includes etiologically heterogeneous disorders characterized by senile or presenile dementia, extracellular amyloid protein aggregations containing an insoluble amyloid precursor protein derivative, and intracytoplasmic tau protein aggregations. Recent studies also show excess neuronal aneuplo...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.12.045
更新日期：2004-01-01 00:00:00
abstract：:Treatment-resistant schizophrenia (TRS) is one of the subgroups of schizophrenia of which little is known with regard to its optimal mechanism. Treatment response, either as full remission of symptoms or prediction by biomarker, is important in psychiatry. We have proposed a model that integrates dopaminergic and glut...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110159
更新日期：2020-10-01 00:00:00
abstract：:Numerous studies implicate cellular immunological effector systems in the partial containment of virus replication during the early stages of HIV infection. Immunostimulatory therapeutic regimes designed to enhance virus clearance are therefore theoretically attractive, but are accompanied by the risk of concomitant a...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(92)90101-h
更新日期：1992-07-01 00:00:00
abstract：:Parkinson disease (PD) is a chronic progressive degenerative disorder that affects over 6 million people worldwide. It is manifested by motor and psychiatric signs. The latter inflicts up to 88% of PD patients. With the prolongation of life expectancy, it is presumed that the prevalence of PD will further rise, togeth...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.07.024
更新日期：2010-12-01 00:00:00
abstract：:Neutrophils are activated in the coronary circulation during acute coronary events (unstable angina and myocardial infarction), often prior to the onset of ischemic damage. Moreover, neutrophils infiltrate coronary plaque in these circumstances, and may contribute to the rupture or erosion of this plaque, triggering t...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.03.040
更新日期：2004-01-01 00:00:00
abstract：:Most of the body iron is found within hemoglobin in red cells (the erythron), a smaller amount being distributed in other tissues such as muscles and in deposits. Iron homeostasis is a finely tuned process in which the most important regulators are probably the liver-derived hepcidin which blocks iron absorption and d...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2014.09.008
更新日期：2014-11-01 00:00:00
abstract：:Arrhythmias is one of the leading causes of death in the world. Current antiarrhythmic drugs are limited by unsatisfactory efficacy and adverse effects such as proarrhythmias. Reentry mechanism plays an important role in persistence of arrhythmias. Reentry can only continue when reentry path-length is longer than card...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.08.047
更新日期：2011-01-01 00:00:00
abstract：:The prevalence of atopic diseases (atopic dermatitis, bronchial asthma, allergic rhinitis) has considerably increased for the last 40 years. This tendency has coincided with the beginning of the epoch of the use of the topical corticosteroids, which have a potent immunomodulation action. This fact itself as well as a ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.12.059
更新日期：2005-01-01 00:00:00
abstract：:Knowledge about how information is stored in neurons of animals and in the human brain is still incomplete. A hypothesis related to long-term changes in synaptic efficiency has strong experimental support, but does not seem to be able to explain all observations. It has recently been proposed that magnetite together w...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.07.003
更新日期：2018-10-01 00:00:00
abstract：:One of the most commonly alleged contraindications to the use of (ethylene diamine tetraacetic acid) chelation therapy is possible renal damage. In this experiment, 13 subjects with chronic degenerative disorders and with renal damage were treated with infusions that included EDTA, vitamins, mineral and oral supplemen...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(84)90020-3
更新日期：1984-11-01 00:00:00
abstract：:Secretion of ovarian hormones directly into the peritoneal cavity has been repeatedly demonstrated for 25 years, but the consequences of this pathway of secretion have not been fully considered. Circumstantial evidence suggests the following hypotheses: (1) Hormones enter the endometrial cavity through the tubes and i...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00029-x
更新日期：2003-06-01 00:00:00
abstract：:Purpura fulminans is a life threatening complication of many septic states, most notably meningococcaemia. It can also occur due to congenital deficiency of anticoagulant proteins. The pathophysiology of purpura fulminans is complex and not fully understood, but involves abnormalities of coagulation pathways, damage t...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.11.011
更新日期：2008-01-01 00:00:00
abstract：:We have formalized extracellular and intracellular volume interaction with each other and the influence of these processes on the type of cell growth. The linearized model was verified by stereo metric solution and the results were compared with experimental data. Two theoretical solutions were found: Solution 1, extr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.06.026
更新日期：2005-01-01 00:00:00
abstract：:Autism continues to be a significant cause of psychosocial pathology in affected children and adults. Until recently, the predominant research thrust to uncover the cause of this condition has been the search for a major nuclear mutation. Although a small percentage of cases do demonstrate such a DNA fault, recent eff...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.10.015
更新日期：2019-01-01 00:00:00
abstract：:The objective of this work is to propose a biomechanical model of sacro-iliac joint dysfunction as a cause of low back pain. Sacro-iliac joint is known to be a source of low back pain. We also know that it is a very stable joint with little mobility. Surrounding lower limb and back muscles contribute a major part of t...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.02.035
更新日期：2005-01-01 00:00:00
abstract：:Solutes concentration in the aqueous humor of the eye is highest near the ciliary processes in the posterior chamber (p.c.) and lowest near the trabecular meshwork in the anterior chamber (a.c.). The high osmotic gradient across the semipermeable iris causes it to easily move forward at this location and occasionally ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00338-9
更新日期：2003-03-01 00:00:00
abstract：:Some recent studies have reported a strong link between obesity and attention-deficit/hyperactivity disorder (ADHD). However, to date, the factors underlying this newly described comorbidity are still unclear and unexplored. In the present article, we proposed that the dopamine system and implicate dopamine genes cont...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.10.012
更新日期：2008-01-01 00:00:00
abstract：:The classical form of Barlow's disease or infantile scurvy, with bruises, broken bones and sores that will not heal, is rarely seen today, but it seems to be reappearing under a different guise, when infants with borderline vitamin C depletion are assaulted with too many inoculations at one time.Moreover, it is now so...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00114-7
更新日期：2002-07-01 00:00:00
