Abstract:
:One of the most commonly alleged contraindications to the use of (ethylene diamine tetraacetic acid) chelation therapy is possible renal damage. In this experiment, 13 subjects with chronic degenerative disorders and with renal damage were treated with infusions that included EDTA, vitamins, mineral and oral supplements. Following 20 infusions, creatinine clearance significantly improved. This report adds credence to the findings of those physicians who have noted that EDTA is a safe and major therapeutic modality in the treatment of chronic cardiovascular diseases. The patients reported in this experiment represent a small part of a much larger group of several hundred individuals undergoing a series of tests to determine the utility of EDTA therapy in subjects with occlusive vascular disorders.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Sehnert KW,Clague AF,Cheraskin Edoi
10.1016/0306-9877(84)90020-3subject
Has Abstractpub_date
1984-11-01 00:00:00pages
301-4issue
3eissn
0306-9877issn
1532-2777pii
0306-9877(84)90020-3journal_volume
15pub_type
杂志文章abstract::In observing the phenomenon of alterations of tumor cell phenotypes, one may envision a mechanism that induces the change in tumor cell characteristics and the appearance of metastasis. Schirrmacher (1) has suggested that the effect of the microenvironment on tumor cells influences the control of gene expression and t...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(81)90010-4
更新日期:1981-05-01 00:00:00
abstract::Acute stroke, including acute ischemic stroke (AIS) and acute hemorrhagic stroke, (AHS) is a common medical problem with particular relevance to the demographic changes in industrialized societies. In recent years, treatments for AIS have emerged, including thrombolysis with tissue plasminogen activator (t-PA). Althou...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.07.038
更新日期:2010-12-01 00:00:00
abstract::Postoperative delirium represents a serious complication after major surgery. Patients suffer from anxiety, hallucinations and delusions, and have higher postoperative morbidity and mortality. Generally, the role of acetylcholine deficiency in delirium pathophysiology is widely accepted. How this pathologic state evol...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.07.003
更新日期:2007-01-01 00:00:00
abstract::A meniscal graft extrusion is still an unresolved problem that affects most patients after a meniscal transplantation. Despite the advances in surgical techniques, together with the improved methods for a meniscal allograft sizing, success is only observed in up to 75% of patients after they experience a meniscal allo...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.02.003
更新日期:2017-04-01 00:00:00
abstract::The lymphatic system is an important component of human health and is critical in maintaining microcirculatory flow and immune system homeostasis. During septic shock, increased capillary permeability results in excess filtration of intravascular fluid and solutes producing interstitial edema with subsequent hydrostat...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109748
更新日期:2020-09-01 00:00:00
abstract::Kawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology that occurs predominantly in children <5 years of age. For the etiopathogenesis of KD, there is no agreement even as to whether KD is an infectious disease or an immune-mediated disease. The epidemiologic characteristics of KD, including...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.12.051
更新日期:2007-01-01 00:00:00
abstract::Vaccines are effective in preventing disease by stimulating the immune system and sustaining an immune response towards eradication of pathogens and diseased cells. However, designing successful vaccines is not always straightforward. For a vaccine to be successful, antigen-presenting cells (APC) need to be stimulated...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.06.013
更新日期:2011-10-01 00:00:00
abstract::Sperm production is regulated by inhibin. Inhibin secretion may be controlled by the number of ejaculations. The more the number of ejaculations, the less the inhibin in blood and the more the production of spermatozoa. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(89)90089-3
更新日期:1989-10-01 00:00:00
abstract::Diabetes is a global public health challenge that imposes heavy burdens on communities and individuals. Metformin, the first-line medication for diabetes, has the superiority of reducing risk of macrovascular diseases, all-cause mortality and even possibly cancers. Recent observational studies, however, have demonstra...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.05.025
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Ovarian cancer has a different prognosis between early (I and II) and advanced stage (III and IV). The mechanism of disease progression is unknown, but patients with advanced disease may have a higher propensity for seeding of the abdominal cavity early in the disease process than those with early stage. The...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.01.027
更新日期:2013-05-01 00:00:00
abstract::Elevated levels of aluminium (Al), strontium (Sr), barium (Ba), iron (Fe), manganese (Mn) cations - combined with deficiencies of magnesium (Mg)/calcium (Ca) - have been observed in the foodchains that traditionally support the Chamorro populations affected by high incidence clusters of Alzheimer (AD), Parkinson-like ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.04.029
更新日期:2004-01-01 00:00:00
abstract::Cardiac chambers have afferent connections to the brainstem and to the spinal cord. Vagal afferents mediate depressor responses and become activated by volume expansion, increased myocardial contractility and atrial natriuretic factor. Sympathetic afferents, on the contrary, are activated by metabolic mediators, myoca...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1999.0029
更新日期:2000-02-01 00:00:00
abstract::Doppler sonography is used as a routine test for detection of renal artery stenosis (RAS). Although increased peak systolic velocity at the site of the narrowing is a widely accepted method for assessing main renal artery stenosis, tardus parvus phenomenon detected on the downstream blood flow has been used as an alte...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.01.016
更新日期:2019-03-01 00:00:00
abstract::Dietary animal fat increases the risk of colorectal cancer. A factor in the increased risk is hypothesised to result from the inhibition of isoforms of a colonic epithelial cell enzyme that detoxifies genotoxins, glutathione S-transferase, by one of the major secondary bile acids produced in the colon by fat digestion...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(92)90168-c
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Short-term acute care public county hospitals in the US were a mainstay of much "safety net" medical care in the early twentieth century. The private sector currently provides much of what was in the past public medical care. Does this transition affect health care indices? METHODS:The presence of public ho...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109265
更新日期:2019-11-01 00:00:00
abstract::For almost 70 years, essential fatty acid deficiency has been known to be associated with skin disorders, vessel abnormalities, and increased tumorigenesis. However, the underlying molecular and cellular mechanism is largely unknown. Recently, it has been reported that essential fatty acids regulate cell adhesion by m...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1998.1191
更新日期:2000-09-01 00:00:00
abstract::Seizure (ictal) behavior in humans has been observed and recorded since ancient times. A satisfactory solution to this vexing problem continues to elude medical science. Antiepileptic drug (AED) therapy fails to control seizures in 20% of patients with primary generalized epilepsy and 35% of patients with partial epil...
journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
doi:10.1016/s0306-9877(02)00348-1
更新日期:2003-01-01 00:00:00
abstract::Tourette syndrome is a chronic, idiopathic, childhood onset neuropsychiatric disorder with both motor and vocal tics. Tourette syndrome occurs worldwide and the clinical features are similar irrespective of the country of origin, with genetic causes suspected, but to date not proven. A link between red hair colour and...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.03.052
更新日期:2009-11-01 00:00:00
abstract::Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play an essential role in tumor-associated immunosuppression, which hampers effective immunotherapeutic approaches. MicroRNAs (miRNAs) are short noncoding RNAs that negatively regulate target gene expression at the posttranscriptional level...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.05.006
更新日期:2014-08-01 00:00:00
abstract::Based on the principles of the altered homeostatic theory, a case will be made that the risk of cardiovascular (CV) events from pharmaceuticals as COX-2 inhibitors (coxibs) and sympatho-mimetic drugs can be reduced significantly by using standard pharmaceutical and lifestyle preventative measures as statins, exercise,...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.05.027
更新日期:2006-01-01 00:00:00
abstract::The paper based on the hypothesis that mechanical impulses cause the transmission of excitement in the peripheral and central nervous system. Possible connections between changes in the tubular neuronal network and the morphological findings of Alzheimer's disease are presented. Additionally, changes in the viscosity ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.02.012
更新日期:2014-05-01 00:00:00
abstract::The globally increasing incidences of Type 1 diabetes (T1DM) and Type 2 diabetes (T2DM) can have a common background. If challenged by the contemporary high level of nutritional glucose stimulation, the β-cells in genetically predisposed individuals are at risk for damage which can lead to the diseases. The fat to car...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.02.027
更新日期:2019-04-01 00:00:00
abstract::Ampligen, a mismatched double stranded RNA, is hypothesized to be an ideal base therapy for HIV disease to which other agents, such as the nucleoside analogue, AZT, can be advantageously added. The unique properties of Ampligen which support this hypothesis include activation of immune cells, inhibition of virus repli...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(92)90002-t
更新日期:1992-01-01 00:00:00
abstract::Acute viral infection is characterised by high-level replication before prompt decline of viraemia and, commonly, viral clearance. This kinetic pattern is generally held to be due to immune control. However, infection with some viruses, notably hepatitis C (HCV), hepatitis B (HBV) and the human immunodeficiency virus ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.02.050
更新日期:2004-01-01 00:00:00
abstract::Arthritis is inflammation in a joint often with joint damage, usually accompanied by pain, swelling and stiffness, resulting from infection, trauma, degenerative changes, metabolic disturbances, autoimmune or other causes. It occurs in various forms, including rheumatoid arthritis, osteoarthritis, bacterial arthritis ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.06.021
更新日期:2005-01-01 00:00:00
abstract::Plasticity of adult cells has been identified in several post-natal tissues in the past few years and has attracted special attention in regenerative medicine. Skin is the biggest organ in the body. Adult skin consists of epidermis, dermis and appendages such as hairs and glands which are linked to the epidermis but p...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2003.12.022
更新日期:2004-01-01 00:00:00
abstract::The etiology of focal distribution of atherosclerotic lesions has received much attention for many years. Current theories focus on mechanical factors such as low endothelial shear stress as an initiating factor for atherosclerosis formation. However, some evidences revealed that it could not be initiator of endotheli...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.11.049
更新日期:2009-12-01 00:00:00
abstract::Synthetic ligands of the retinoid X receptor (RXR) have shown antidiabetic activity in mice, apparently owing to the fact that they stimulate the transcriptional activity of PPAR-gamma/RXR heterodimers, much like thiazolidinedione drugs. The chlorophyll metabolite phytanic acid has been shown to be a natural ligand fo...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2000.1153
更新日期:2001-02-01 00:00:00
abstract::Currently, drug repurposing is an alternative to novel drug development for the treatment of COVID-19 patients. The antimalarial drug chloroquine (CQ) and its metabolite hydroxychloroquine (HCQ) are currently being tested in several clinical studies as potential candidates to limit SARS-CoV-2-mediated morbidity and mo...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109815
更新日期:2020-09-01 00:00:00
abstract::From biographical data sources on ranking scientists, I was able to identify 35 centenarians. Among these, only one (Michel Chevereul from France) lived before the 20th century. Since the remaining 34 individuals became centenarians only from 1965, I propose that centenarian scientists are an unusual cluster, first fo...
journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
doi:10.1054/mehy.2001.1480
更新日期:2001-12-01 00:00:00