Abstract：
:Some recent studies have reported a strong link between obesity and attention-deficit/hyperactivity disorder (ADHD). However, to date, the factors underlying this newly described comorbidity are still unclear and unexplored. In the present article, we proposed that the dopamine system and implicate dopamine genes contribute to explaining the association between ADHD and obesity. The background for this hypothesis comes from studies on the association between ADHD and dopamine, as well as from investigations on dopamine in obese individuals. There is strong evidence that indicate catecholamines dopamine is very important in the pathophysiology of ADHD, as well as in the mechanism of therapeutic action of stimulant drugs. Furthermore, increasing evidence indicated that dopaminergic reward system is significantly associated with obesity. With regard to the therapeutic implications, recent studies indicate that methylphenidate (MPH) - a drug widely used for ADHD reduced overall energy intake with a selective reduction in dietary fat. Findings are consistent with a reward deficiency model of obesity whereby low brain dopamine predicts overeating and obesity, and administering agents that increase dopamine results in reduced feeding behavior. Given the above background, we hypothesize that the increased prevalence of ADHD in obese individual could be explained by the imbalance of dopaminergic reward system.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Liu LL,Li BM,Yang J,Wang YWdoi
10.1016/j.mehy.2007.10.012subject
Has Abstractpub_date
2008-01-01 00:00:00pages
1118-20issue
6eissn
0306-9877issn
1532-2777pii
S0306-9877(07)00636-6journal_volume
70pub_type
杂志文章abstract：:Breast and ovarian cancer rates in Pakistan are significantly higher than in neighboring countries. The cancer rate discrepancies cannot be explained with discrepancies of their risk factors. We propose that observed cancer excess in Pakistan is due to cancer development by negative heterosis. Heterosis occurs when a ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.10.013
更新日期：2005-01-01 00:00:00
abstract：:The author presents evidence from published papers of research done by numerous investigators that Multiple Sclerosis (MS) is an autoimmune disease, that the target tissue is the myelin sheath which covers the nerve fibers in the brain and spinal cord, that Myelin Basic Protein (MBP) is the antigen or one of the antig...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(88)90061-8
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abstract：:The per review system for the assessment of research proposals is widely respected by working scientists. Nevertheless two problems associated with the operation of this system by the US National Institutes of Health are identified. First the scientist has no control over which committee will review an application and...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(76)80019-9
更新日期：1976-01-01 00:00:00
abstract：:Sixty percent of cases of clinical depression are considered to be treatment-resistant depression (TRD). Magnesium-deficiency causes N-methyl-d-aspartate (NMDA) coupled calcium channels to be biased towards opening, causing neuronal injury and neurological dysfunction, which may appear to humans as major depression. O...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2009.10.051
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Short-term acute care public county hospitals in the US were a mainstay of much "safety net" medical care in the early twentieth century. The private sector currently provides much of what was in the past public medical care. Does this transition affect health care indices? METHODS:The presence of public ho...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109265
更新日期：2019-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2014.12.002
更新日期：2015-02-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1997.0695
更新日期：1999-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.05.013
更新日期：2015-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(90)90037-f
更新日期：1990-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/s0306-9877(03)00175-0
更新日期：2003-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(83)90093-2
更新日期：1983-07-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.09.015
更新日期：2011-02-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1539
更新日期：2002-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.06.023
更新日期：2011-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
doi：10.1016/0306-9877(92)90179-g
更新日期：1992-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(79)90046-x
更新日期：1979-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1997.0645
更新日期：1999-03-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110038
更新日期：2020-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(91)90261-v
更新日期：1991-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1517
更新日期：2002-05-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.04.041
更新日期：2006-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2012.02.023
更新日期：2012-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(86)90138-6
更新日期：1986-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.03.020
更新日期：2017-05-01 00:00:00
abstract：:Interferon-alpha (IFN) is widely used in the treatment of certain cancers and viral infections, including hepatitis C (HCV). Unfortunately, depression is a common side effect of IFN therapy, affecting approximately a third of HCV patients receiving IFN therapy. Studies have shown that selective serotonin reuptake inhi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.01.026
更新日期：2005-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.03.010
更新日期：2017-05-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.01.046
更新日期：2009-07-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(84)90156-7
更新日期：1984-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109976
更新日期：2020-11-01 00:00:00
abstract：:Researchers have recently reported a possible inverse relationship between taking steroids or non-steroidal anti-inflammatory drugs, or both, and the development of Alzheimer's disease. In this article it is hypothesized that the reduction in the human body of the amount of available arachidonic acid, the precursor of...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(98)90007-x
更新日期：1998-04-01 00:00:00
