Cytokine-serotonin interaction through IDO: a neurodegeneration hypothesis of depression.

abstract：:The number of deaths per year from hepatocellular carcinoma (HCC) exceeds 250000, placing it sixth as the cause of death from cancer worldwide. The primary etiology of most cases of HCC in the US is hepatitis B and/or C. Extensive research has demonstrated that the relationship between hepatitis B infection and the pr...

journal_title：Medical hypotheses

authors： Steel J,Carney M,Carr BI,Baum A

更新日期：2004-01-01 00:00:00

abstract：:Humans vary in the gene that encodes for Vitamin K epoxide reductase complex (VKORC1). Recent research has documented the protective effect of Vitamin K on neural cells and its role in maintaining normal neural development. Of interest, specific neural effects of Vitamin K overlap with key brain development aberration...

journal_title：Medical hypotheses

authors： DeSoto MC

更新日期：2016-11-01 00:00:00

abstract：:The thickness of the choroid is measured on the optical coherence tomography (OCT) as the distance between the hyperreflective retinal pigment epithelium and the hyperreflective chorio-scleral junction, contributed by the choroidal vessels and choroidal melanocytes. Our hypothesis is that the amount of absorption and ...

journal_title：Medical hypotheses

authors： Venkatesh R,Reddy NG,Chhablani J

更新日期：2021-01-01 00:00:00

abstract：:The water proton spin lattice relaxation time of normal and tumorous tissues of human and radiosensitivity yield a linear relationship. ...

journal_title：Medical hypotheses

authors： Akber SF

更新日期：1995-06-01 00:00:00

abstract：:It is well documented that depressed patients, as a result of their illness, often experience some difficulties with their memory. This hypothesis suggests a vice-versa; that it is a gradual impairment and ultimate failure of specific memory systems that may underpin the onset and continuation of a depressive illness....

journal_title：Medical hypotheses

authors： Frais AT

更新日期：2007-01-01 00:00:00

abstract：HYPOTHESIS:The delayed lung damage after SARS-CoV-2 infection may be caused by an autoimmune response to ACE2 induced by forced presentation of the ACE2 protein in a complex with CoV Spike in Fc Receptor positive Antigen Presenting Cells in the lung. The likelihood that this hypothesis is valid is low, but it is easily...

journal_title：Medical hypotheses

authors： Townsend A

更新日期：2020-11-01 00:00:00

abstract：:Knowledge about how information is stored in neurons of animals and in the human brain is still incomplete. A hypothesis related to long-term changes in synaptic efficiency has strong experimental support, but does not seem to be able to explain all observations. It has recently been proposed that magnetite together w...

journal_title：Medical hypotheses

authors： Alfsen EM,Størmer FC,Njå A,Walløe L

更新日期：2018-10-01 00:00:00

abstract：:We have previously presented a new Systemic Evolutionary Theory of Cancer (SETOC) based on the failure of proper endosymbiosis in eukaryotic cells. Here, we propose that the progressive uncoupling of two endosymbiotic subsystems (information and energy) inside the cell, as a consequence of long-term injuries, gives ri...

journal_title：Medical hypotheses

authors： Mazzocca A,Ferraro G,Misciagna G,Fais S

更新日期：2018-12-01 00:00:00

abstract：:Complex Regional Pain Syndrome (CRPS) has defied a clear unified pathological explanation to date. Not surprisingly, treatments for the condition are limited in number, efficacy and their ability to enact a cure. Whilst many observations have been made of physiological abnormalities, how these explain the condition an...

journal_title：Medical hypotheses

authors： Russo M,Georgius P,Santarelli DM

更新日期：2018-10-01 00:00:00

abstract：:Almost all solid tumors consist of aneuploid cells with highly abnormal chromosome numbers. Such cancer cells could very well originate from chromosome missegregation which is a disturbingly common phenomenon, happening in 0.01 to 4 percent of cell divisions. Missegregated cells are aneuploid, typically lacking a chro...

journal_title：Medical hypotheses

authors： Engvild KC

更新日期：2018-11-01 00:00:00

abstract：:A major factor relating to the oversight of neurological dysfunction and seizures caused by magnesium (Mg++) depletion, involves the buffer functions of the skeletal system orchestrated primarily by the parathyroid. A Mg++ depleted subject may appear relatively asymptomatic until a short period after homeostatic respo...

journal_title：Medical hypotheses

authors： Langley WF,Mann DJ

更新日期：1991-01-01 00:00:00

abstract：:Several studies have demonstrated the existence of morphological, biological, genetic and antigenic correlations between human and animal retroviruses. Furthermore, some agents of bovine and feline origin can also be considered useful comparative models for the pathogenetic study of human diseases such as leukaemia, a...

journal_title：Medical hypotheses

authors： Di Guardo G

更新日期：1989-07-01 00:00:00

abstract：:Gender differences in stem cell population have recently been identified. Blood and tissue samples from women showed consistent elevation of hematopoietic stem cell populations, mesenchymal stem cell populations and endothelial progenitor cells compared to men of similar ages. We and others have shown an increase in h...

journal_title：Medical hypotheses

authors： El-Badri NS,Groer M

更新日期：2012-10-01 00:00:00

abstract：:No single dietary factor or ingested substance has been implicated in the aetiology of oesophageal carcinoma especially in high-risk areas of the world. Although not well defined, there is heavy consumption of tannin-rich foods, particularly sorghum, by populations at high risk for carcinoma. The carcinogenic properti...

journal_title：Medical hypotheses

authors： Warner TF,Azen EA

更新日期：1988-06-01 00:00:00

abstract：:Aspirin, today, is an established drug in the regime for the prevention of myocardial infarction, especially in high-risk groups. This use of aspirin has given it a new lease of life in its tenth decade of clinical use. Aspirin is probably the oldest synthetic drug in the Pharmacopoeias today; thus one would have imag...

journal_title：Medical hypotheses

authors： Ghooi RB,Thatte SM,Joshi PS

更新日期：1995-02-01 00:00:00

abstract：:Articles dealing with the epidemiological aspects of asthma were carefully reviewed in order to support or reject our clinical impression of increased rate of asthma among immigrants. Particular emphasis was put on data on very high or very low rates of asthma. The proposed theories to explain these differences were c...

journal_title：Medical hypotheses

authors： Ballin A,Somekh E,Geva D,Meytes D

更新日期：1998-10-01 00:00:00

abstract：:The etiology of Insulin Dependent Diabetes Mellitus (IDDM) is reviewed and discussed using Rothman's deterministic model for causal inference. Intercontinental comparisons, familial aggregation, seasonal variation, maternal age, breast-feeding and infectious agents are reviewed within the context of IDDM causation. Ge...

journal_title：Medical hypotheses

authors： Sumburèru D

更新日期：1991-08-01 00:00:00

abstract：:There are differences in male and female height throughout the growth period. Utilising reference standard height charts we calculated the difference in male and female height as a function of age. A triphasic relationship was observed with statistically significant peaks (males greater than females) at 8 months and 1...

journal_title：Medical hypotheses

authors： Schreiber G,Baron B

更新日期：1984-07-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder, characterized by loss of dopaminergic neuromelanin containing neurons in the substantia nigra. Peripheral melanin, found in skin and hair, and neuromelanin appear to have some characteristics in common and share the same precursor for their synthesis; therefore...

journal_title：Medical hypotheses

authors： Jucevičiūtė N,Banaitytė I,Vaitkus A,Balnytė R

更新日期：2019-06-01 00:00:00

abstract：:The rigid gas permeable contact lens (RGPCL) is an ideal choice to improve the corrective vision of patients with a high degree of refractive error, keratoconus and corneal transplantation. However, RGPCL fitting is not an easy work for those patients with extremely irregular corneal surface. Technicians or doctors of...

journal_title：Medical hypotheses

authors： Zhao F,Zhao G,Weijie F,Chen L

更新日期：2018-04-01 00:00:00

abstract：:Superficial fraying, splitting and fibrillation of articular cartilage as a consequence of ageing or mechanical injury is not always associated with joint pain. However, similar cartilage lesions accompanied by synovitis and engorgement of the subchondral vasculature generally is; the disorder being known as osteoarth...

journal_title：Medical hypotheses

authors： Ghosh P,Smith M

更新日期：1993-08-01 00:00:00

abstract：:Although fibrosis and emphysema are in many ways on opposite ends of the pulmonary parenchymal disease spectrum, they seem to share common pathomechanistic steps. This is illustrated by the coexistence of both entities in lungs of individuals with combined pulmonary fibrosis and emphysema. Macroproteins elastin and co...

journal_title：Medical hypotheses

authors： Janssen R,de Brouwer B,von der Thüsen JH,Wouters EFM

更新日期：2018-11-01 00:00:00

abstract：:On the basis of the physical properties of magnetic fluids a new technique of whole-body hyperthermia is proposed. Subdomain dextran stabilized magnetite particles injected into the blood-stream can be efficiently heated using an external high-frequency magnetic field, which allows rapid and controllable delivery of h...

journal_title：Medical hypotheses

authors： Babincová M,Sourivong P,Leszczynska D,Babinec P

更新日期：2000-12-01 00:00:00

abstract：:Contrast-induced nephropathy (CIN) is regarded as acute tubular necrosis resulting from the cytotoxicity of contrast media and the medullary hypoxia linking to the interplay of vasoconstriction and vasodilatation. Saline infusion may prevent CIN by inhibiting renin release and thus production of angiotensin II (ANG II...

journal_title：Medical hypotheses

authors： Wong PC,Guo J,Zhang A

更新日期：2015-12-01 00:00:00

abstract：:A hypothesis which explains disease prevalence among different socio-economic groups following early infantile modulation of cell-mediated immunity by infection and nutrition related stress is presented. Wealthy populations living under highly hygienic circumstances can develop their cell-mediated immunity to genetic ...

journal_title：Medical hypotheses

authors： Dutz W

更新日期：1975-11-01 00:00:00

abstract：:The symptom spectra of several 'popular press' diagnoses are examined and compared to Diagnostic and Statistical Manual of Mental Disorders-IIIR criteria for somatization disorder, depression, and generalized anxiety disorder. While there is much overlap, there are clear distinctions, and these psychiatric terms do no...

journal_title：Medical hypotheses

authors： Elks ML

更新日期：1996-04-01 00:00:00

abstract：:The accepted paradigms of mainstream neuropsychiatry appear to be incompletely adequate and in various cases offer equivocal analyses. However, a growing number of new approaches are being proposed that suggest the emergence of paradigm shifts in this area. In particular, quantum theories of mind, brain and consciousn...

journal_title：Medical hypotheses

authors： Tonello L,Cocchi M,Gabrielli F,Tuszynski JA

更新日期：2017-04-01 00:00:00

abstract：:The rise of anatomical realism in sculpture with the Classical Greeks puzzles art historians. Recently, it has been discovered that the motor cortex perceives motor actions. I argue that Classical artists discovered a new aesthetic based on using art to stimulate not just, as previously, the visual cortex, but also th...

journal_title：Medical hypotheses

authors： Skoyles JR

更新日期：1998-07-01 00:00:00

abstract：:Natural whole foods contain fats as structural components, and have a balance of polyunsaturated fat, monounsaturated fat, and saturated fat. Since we are still a Paleolithic species, adapted to eating only wild foods, it is difficult to justify the consumption of anything other than an overall balance of triglyceride...

journal_title：Medical hypotheses

authors： Broadhurst CL

更新日期：1997-09-01 00:00:00

abstract：:In light of the progressive, pubertal increases in serum gonadotropin (FSH, LH) levels coinciding with the peak incidence of simple goiters; the common alpha subunits associated with the gonadotropins, TSH and hCG; the ability of LH and hCG to bind to thyroid TSH receptors and affect thyroid function; and, the probabl...

journal_title：Medical hypotheses

authors： DiNicola AF

更新日期：1983-04-01 00:00:00