Correlation between spin lattice relaxation time and radiation sensitivity in human tissues.

abstract：:The paper discusses a mechanism for reciprocal translocation of midsegments between two chromatids so that one of the segments is restacked in inverted configuration. Regarding malignant cells, such process could derive from anachronistic assembly of the nuclear envelope. ...

journal_title：Medical hypotheses

authors： Matioli GT

更新日期：1998-06-01 00:00:00

abstract：:A large number of epileptic patients suffer from refractory epilepsy, despite optimal treatment; thus these patients require new therapeutic approaches. Focal seizure activity is typically initiated in a fixed and localized region, which subsequently spreads to neighboring regions or more distant areas. At the initial...

journal_title：Medical hypotheses

authors： Zhang L,Liang S,Zhang G,Kang X

更新日期：2013-11-01 00:00:00

abstract：:Trigeminal neuralgia is a painful condition that causes great discomfort. Although this disease has been known for more than 1000years, there is still no consensus on its underlying mechanism or treatment. Many hypotheses have been reported to explain the cause and nature of trigeminal neuralgia. These include theorie...

journal_title：Medical hypotheses

authors： Peker S,Sirin A

更新日期：2017-03-01 00:00:00

abstract：:The time of re-evaluation of the role of human immunodeficiency viruses in the pathogenesis of acquired immune deficiency syndrome has now come, now that methods are available for the direct detection of human immunodeficiency viruses and for the detection of cellular anti-human immunodeficiency virus immune reactions...

journal_title：Medical hypotheses

authors： Hässig A,Wen-Xi L,Stampfli K

更新日期：1996-04-01 00:00:00

abstract：:Micelle is a stable, passively targetable and solubilizing minute particle, and plays a key role to anticancer drug delivery for chemotherapy. With an increasing number of novel polymeric micelles synthesized, many anticancer drugs have been core-encapsulated in the micelles. However, only single drug was studied as t...

journal_title：Medical hypotheses

authors： Liu P,Wang B,Weili Qiao JL

更新日期：2008-09-01 00:00:00

abstract：:Over the last century and a half there has been a secular decline in the age of menarche in Western, industrialized cultures. This trend has been largely ascribed to improved nutrition and health, and we offer an alternative hypothesis that changes in socio-economic conditions have resulted in changes in the pheromona...

journal_title：Medical hypotheses

authors： Burger J,Gochfeld M

更新日期：1985-05-01 00:00:00

abstract：:The German doctor Hermann Kümmell described Kümmell's disease as the clinical scenario in which patients suffer a trivial spinal trauma, but develop a symptomatic, progressive, angular kyphosis after a symptom-free period of months to years. Since an intravertebral vacuum phenomenon, which is considered indicative of ...

journal_title：Medical hypotheses

authors： Li H,Liang CZ,Shen CC,Chen QX

更新日期：2011-11-01 00:00:00

abstract：:This hypothesis clearly proposes the true and previously undiscovered cause of male homosexuality or bisexuality and in most cases the predictability in infancy of the development of this sexuality in adulthood. It is based on compelling new evidence which has accumulated over many years. The fetal and neonatal period...

journal_title：Medical hypotheses

authors： Roper WG

更新日期：2016-09-01 00:00:00

abstract：:An expansion of the 'stable' gene hypothesis proposed previously is the hypothesis that there is a range of genes, some proto-oncogenes and some not, varying from those with multiple copies in the genome, wide distribution among species, and limited mutability because of a specific protective stabilizing mechanism of ...

journal_title：Medical hypotheses

authors： Frei JV

更新日期：1995-02-01 00:00:00

abstract：:Obstructive sleep apnea is characterized by episodes of intermittent hypoxia that occur while the afflicted person sleeps, and is believed to affect and have a negative impact on many people worldwide. Both observational evidence in obstructive sleep apnea patients and direct studies in mice mimicking the disease stro...

journal_title：Medical hypotheses

authors： Johnson PR

更新日期：2008-10-01 00:00:00

abstract：UNLABELLED:Teeth start as bi-layered epithelial soft tissue follicles within bony jaws. Follicles grow into teeth and erupt. Early third molar follicles are detectable 8-9 years (±9 months). Intra-oral dental arches of jaws have finite space accommodating formed crowns. The last teeth to erupt are third molars. When th...

journal_title：Medical hypotheses

authors： Touyz LZ,Dent M

更新日期：2012-09-01 00:00:00

abstract：:Herein it is hypothesized that M2-like macrophages or pre-macrophages of fetal origin might play a central role in development and closure of the neural tube. Early in embryonic development, pre-macrophages arise from the fetal yolk sac and track through the bloodstream to reach diverse embryonic tissues, where they m...

journal_title：Medical hypotheses

authors： Block J

更新日期：2019-08-01 00:00:00

abstract：:Aspirin, today, is an established drug in the regime for the prevention of myocardial infarction, especially in high-risk groups. This use of aspirin has given it a new lease of life in its tenth decade of clinical use. Aspirin is probably the oldest synthetic drug in the Pharmacopoeias today; thus one would have imag...

journal_title：Medical hypotheses

authors： Ghooi RB,Thatte SM,Joshi PS

更新日期：1995-02-01 00:00:00

abstract：:Muscle spindles are increasingly recognized as playing a pivotal role in the cause of dystonia. This development and own laryngeal observations that support the idea of causally "well-intentioned" stuttering motivated us to present the following hypothesis: stuttering events compensate for a sensory problem that arise...

journal_title：Medical hypotheses

authors： Schuster SH,Schuster FM

更新日期：2012-07-01 00:00:00

abstract：:A hypothesis is suggested, which emphasizes the role in carcinogenesis of the attack on low molecular nucleophilic substances (LMN) by electrophilic agents - chemical carcinogens, phisical factors, and antitumor alkylating agents. The significance of the degree of nucleophilicity (electronic charge, order of bonds, in...

journal_title：Medical hypotheses

authors： Raikov ZD,Christova-Georgieva NI,Raikova ET

更新日期：1987-01-01 00:00:00

abstract：:The accepted paradigms of mainstream neuropsychiatry appear to be incompletely adequate and in various cases offer equivocal analyses. However, a growing number of new approaches are being proposed that suggest the emergence of paradigm shifts in this area. In particular, quantum theories of mind, brain and consciousn...

journal_title：Medical hypotheses

authors： Tonello L,Cocchi M,Gabrielli F,Tuszynski JA

更新日期：2017-04-01 00:00:00

abstract：:The pathogenesis of seasonal affective disorder (SAD) has been attributed to abnormal melatonin metabolism. Perorally administered psoralens increase the daytime levels of melatonin via the competitive inhibition of hepatic melatonin metabolism. Some findings among SAD patients are parallel to those observed after the...

journal_title：Medical hypotheses

authors： Partonen T

更新日期：1998-06-01 00:00:00

abstract：:A novel substance-attributed biophysical theory of brain-mind unity is presented. We separate spiritualism and matters of the soul from the medical sphere. Biophysical principles are responsible for the body's operational regimen (BOR) in the homeostatic state which allows for materialization and emergence of the mind...

journal_title：Medical hypotheses

authors： Naisberg Y

更新日期：2000-03-01 00:00:00

abstract：:The paper studies how certain topologic features of the nuclear envelope may reorganize entrained transcription via spatial rearrangements of genes carried by distinct chromatids. ...

journal_title：Medical hypotheses

authors： Matioli GT

更新日期：1995-07-01 00:00:00

abstract：:For many years, the ketogenic diet, including recent variants such the medium-chain triglyceride (MCT) diet, has been used with good clinical results in the management of refractory epilepsies, particularly in children. The antiepileptic effects of the diet, like the antiepileptic effects of starvation, have been attr...

journal_title：Medical hypotheses

authors： Mainardi P,Albano C

更新日期：2008-01-01 00:00:00

abstract：:Oral glucosamine has anti-inflammatory activity in rodents, and anecdotal evidence suggests that it may be clinically useful in inflammatory bowel disorders. A possible explanation is that supplemental glucosamine increases production of heparan sulfate (HS) proteoglycans by the vascular endothelium, thereby improving...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：1998-07-01 00:00:00

abstract：:Glaucoma is the leading cause of irreversible blindness worldwide, which is now viewed as a disease of brain with pathogenesis not fully understood. The main diagnostic methods are examining the retinal nerve fiber layer through optical coherence tomography and investigating visual field defect, but these methods pres...

journal_title：Medical hypotheses

authors： Sun Y,Huang W,Li F,Li H,Wang L,Huang Y,Zhang X

更新日期：2019-02-01 00:00:00

abstract：:In view of the limited success of available treatment modalities for metastatic tumor, alternative and complementary strategies need to be developed. Oncolytic viruses are capable of selective replication in malignant cells and therefore offer levels of potency and specificity that are potentially far higher than conv...

journal_title：Medical hypotheses

authors： Deng W,Jia J

更新日期：2008-01-01 00:00:00

abstract：:Anorexia nervosa was explored as the possible expression of an aberration of the processing of information which ordinarily has value in life protection or extension. Each of 6 areas was briefly reviewed, and noted to have the potential for failure to balance 2 or more factors. Anorexia nervosa may prove to be a psych...

journal_title：Medical hypotheses

authors： Spencer RP

更新日期：1990-09-01 00:00:00

abstract：:By influencing fetal brain development pregnancy may be prolonged beyond term for an unknown time period. In late gestation the mother animal (host) is nephrectomized. The urine of the fetus (transplant) is guided to the outside so that the fetal kidneys excrete the host's urinary secretory substances and eventually h...

journal_title：Medical hypotheses

authors： Metka W

更新日期：1982-10-01 00:00:00

abstract：:It was hypothesized decades ago that reduced levels of brain monoamines such as serotonin or norepinephrine form, at least in part, a pathophysiological basis for major depression. Consistent with this hypothesis, a conventional strategy used, with varying success, to treat major depression involves administering anti...

journal_title：Medical hypotheses

authors： Fitzgerald PJ

更新日期：2013-06-01 00:00:00

abstract：:So far, the pathogenesis of Alzheimer's disease (AD) has not been clarified, nor has patient therapy been satisfactory. Although inheritance dominates the less frequent early-onset AD in young and middle-aged individuals, environmental and immunogenetic factors have been identified in the most frequently occurring lat...

journal_title：Medical hypotheses

authors： Laumbacher B,Fellerhoff-Loesch B,Wank R

更新日期：2017-02-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is a common neuropsychiatric complication of liver disease affecting about 20-30% patients with cirrhosis. HE may only affect quality of life (e.g. impairments in attention; coordination; driving ability), but in some patients this progresses to coma and death; defining mortality in those w...

journal_title：Medical hypotheses

authors： Jalan R,Wright G,Davies NA,Hodges SJ

更新日期：2007-01-01 00:00:00

abstract：:Interleukin (IL)-1, an established mediator of inflammation, is also a mediator of ovulation (a cyclic inflammatory-like process). We have shown that IL-1 beta induces the in vitro expression of genes believed to play important role in ovulation (IL-1 beta itself, its receptors, IL-1 beta receptor antagonist, glucose ...

journal_title：Medical hypotheses

authors： Kol S,Kehat I,Adashi EY

更新日期：2002-01-01 00:00:00

abstract：:The AIDS dementia complex and peripheral neuropathy in AIDS are considered to be direct or indirect manifestations of HIV infection, yet the pathogenesis in unclear. There are parallels between AIDS and Tangier disease clinically and histopathologically and in lipid metabolism. The neurological disorders in AIDS may b...

journal_title：Medical hypotheses

authors： Falkenbach A,Klauke S,Althoff PH

更新日期：1990-09-01 00:00:00