Abstract:
:Intrauterine growth retardation (IUGR) is associated with insulin resistance, non-insulin-dependent diabetes mellitus (NIDDM) and cardiovascular diseases in adulthood. Postnatal tissues contain stem cells that though quiescent, retain their capacity to self-renew and regenerate tissues to fulfil organ demands. I propose that intrauterine malnutrition reduces the number of tissue stem cells, eventually leading to an early exhaustion of organ function, especially when demands are increased. This hypothesis implies that early prevention of long-term consequences of IUGR should be aimed at inducing proliferation, differentiation and survival of stem cells or reversing the differentiation state of mature cells.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Cianfarani Sdoi
10.1016/s0306-9877(03)00182-8keywords:
subject
Has Abstractpub_date
2003-09-01 00:00:00pages
401-4issue
3eissn
0306-9877issn
1532-2777pii
S0306987703001828journal_volume
61pub_type
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