Abstract:
:Spontaneous acute occlusion of the coronary artery produces regional myocardial ischemia and infarction. This coronary occlusion could be due to rapid progression of atherosclerosis or vasospasm. The factors that can precipitate an acute attack of myocardial infarction or coronary spasm are not known. It is proposed that a stress-induced rise of unesterified arachidonic acid could trigger a leukocyte respiratory burst with the release of free radicals such as superoxide anion (O2-), hydrogen peroxide, hydroxyl radical, and singlet oxygen. These free radicals have the ability to inhibit prostacyclin (PGI2) formation and enhance the breakdown of endothelium-derived vascular relaxing factor (EDRF) which are potent vasodilators and platelet anti-aggregators. This may lead to rapid progression of atherosclerosis or coronary vasospasm leading to acute myocardial infarction. If this is true, free radical quenchers and inhibitors of leukocyte oxidative burst may be useful in the prevention of progression of atherosclerosis and coronary vasospasm.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Das UNdoi
10.1016/0306-9877(92)90147-5keywords:
subject
Has Abstractpub_date
1992-09-01 00:00:00pages
90-4issue
1eissn
0306-9877issn
1532-2777pii
0306-9877(92)90147-5journal_volume
39pub_type
杂志文章abstract::Pro PSA, the precursor of PSA, is an inactive 244-amino acid protein secreted by prostatic cells. Pro PSA, a distinct molecular form of free PSA in serum, includes native as well as several truncated forms. Clinical studies have recently provided evidence that pro PSA is associated with prostate cancer (PCa). The trun...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.06.006
更新日期:2005-01-01 00:00:00
abstract::A theoretical consideration of the relationship between plasma concentrations of calcium and parathyroid hormone suggests that the reported negative correlations between these variables in normal subjects and in patients with secondary hyperparathyroidism, and the positive correlation in patients with primary hyperpar...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(77)90043-3
更新日期:1977-01-01 00:00:00
abstract::Initial diagnosis of acute kidney injury (AKI) is usually based on measuring serum-creatinine and blood urea nitrogen levels; however such measurements are still poor in identifying renal injuries at initial stages. These standard matrices are not enough to monitor the outcome and progression of AKI. The prognosis pre...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.08.011
更新日期:2016-10-01 00:00:00
abstract::Nasopharyngeal angiofibroma is a histologically benign tumor composed of stroma and vessels. The vascular component of the lesion is prone to bleeding and responsible for its clinical "malignancy". Some nasopharyngeal angiofibromas are resistant to surgical therapy because of extensive growth and occasionally bone des...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.06.011
更新日期:2008-01-01 00:00:00
abstract::Ultrasound (US) is gaining recognition as a useful tool for assessing lung physiology and pathology. Yet, currently the skill of performing lung US is taught by experienced operators to novice ones, mainly by recognizing expected patterns. Recognizing the latter may be difficult and subjective. In this hypothesis we p...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.04.019
更新日期:2016-06-01 00:00:00
abstract::Numerous studies indicate that aberrant amyloid precursor protein metabolism, elevated peroxidative damage, depressed energy metabolism and altered calcium homeostasis are four pivotal deleterious factors in the pathogenesis of Alzheimer's disease. Cumulative evidence further suggests that these four factors are intim...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(96)90021-3
更新日期:1996-05-01 00:00:00
abstract::The exact contribution of the sirtuin family of NAD+-dependent histone deacetylases to longevity in metazoans is, at present, not completely understood but nonetheless regarded as significant. Despite the rapidly accreting evidence solidifying the role of NAD+-dependent histone deacetylase activity in longevity-promot...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.08.032
更新日期:2006-01-01 00:00:00
abstract::A nutraceutical that has exploded onto the prescription pad in recent years is the fat soluble vitamin, vitamin D. This is due to an increasing medical interest in the utility of the vitamin in the treatment and prevention of an array of diseases and ailments. Despite the continued debate over the correct dose, form a...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.07.022
更新日期:2013-10-01 00:00:00
abstract::Endemic cancer of the oesophagus in Africa is associated with the use of maize as the staple. In one African community endemic cancer of the oesophagus has been shown to have a strong statistical association with the consumption of foods based on maize in the meal form. A strong association with consumption of maize m...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.05.037
更新日期:2006-01-01 00:00:00
abstract::'Electrohypersensitivity' is often explained as a psychological syndrome. Our modern environment contains a lot of different substances and some of them are toxic. Mycotoxins are types of toxins that are biologically very active and that affect living organisms. Mycotoxins and fungi capable of producing toxins have be...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1999.1045
更新日期:2000-09-01 00:00:00
abstract::The hypothesis of the evolutionary origin of bipolar disorder (EOBD) synthesized ideas about the biological clock and seasonal shifts in mood (Rosenthal, Wehr) with theorizing that bipolar disorder descends from a pyknic (compact, cold-adapted) group (Kretchmer). The hypothesis suggested that bipolar behaviors evolved...
journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
doi:10.1016/j.mehy.2011.10.005
更新日期:2012-01-01 00:00:00
abstract::A holistic-organismic approach is suggested as foundation for intensified, systematic inquiry into relationships among adult attachment styles and various dimensions of physical and mental health. Exploratory findings of differences in stamina associated with adult attachment style are noted. The extent to which attac...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(03)00125-7
更新日期:2003-07-01 00:00:00
abstract::Although once considered by biologists almost exclusively for their toxicity, reactive oxygen (ROS) and nitrogen (RNS) species produced within normal cells under baseline physiological conditions are now appreciated as redox regulators of a wide range of protein functions. Two families of enzymes, the NADPH oxidases (...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109249
更新日期:2019-08-01 00:00:00
abstract::The role of ozone on earth is controversial, as in the stratosphere it is protective against excessive ultra violet irradiation, and in the troposphere it is toxic for animals and plants. The effectiveness of ozone against pathogens is well recognized and ozone appears to be the best agent for sterilization of water. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(96)90016-x
更新日期:1996-02-01 00:00:00
abstract::Extracellular matrix metalloproteinase inducer (EMMPRIN), which is also called BASIGIN/CD147, is a cell surface glycoprotein that belongs to the immunoglobulin superfamily and plays a significant role in intercellular recognition in immunology, cellular differentiation and development. Apart from ACE-2, recently EMMPR...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.110089
更新日期:2020-10-01 00:00:00
abstract::We have previously presented a new Systemic Evolutionary Theory of Cancer (SETOC) based on the failure of proper endosymbiosis in eukaryotic cells. Here, we propose that the progressive uncoupling of two endosymbiotic subsystems (information and energy) inside the cell, as a consequence of long-term injuries, gives ri...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2018.09.033
更新日期:2018-12-01 00:00:00
abstract::Cholesterol efflux from macrophage foam cells, the initial step of reverse cholesterol transport, is assumed to be the most relevant step with respect to atherosclerosis. As one of the ATP-binding cassette transporter (ABC) family members, ABCG1 plays a critical role in the process of cholesterol efflux. It has been r...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.06.042
更新日期:2007-01-01 00:00:00
abstract::Alpha-fetoprotein (AFP) is overexpressed in the majority of hepatocellular carcinomas (HCCs), and thus may offer attractive target for immunotherapy against this neoplasm. CD40 ligand (CD40L) is the major signal that induces B cells to efficiently present antigen to T cells, and CD40-activated B (CD40-B) lymphocyte ce...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.12.050
更新日期:2009-11-01 00:00:00
abstract::Stress, in its many forms, is long associated with the etiology and course of schizophrenia. The mechanisms mediating the impacts of stress are not fully elucidated. Here it is proposed that stress induced cortisol alters kynurenic acid (KA) and quinolinic acid (QA) in the cortex and amygdala/striatum, respectively. T...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.08.029
更新日期:2011-01-01 00:00:00
abstract::COVID-19 exacts a disproportionate toll on both the elderly and those with diabetes; these patients are more likely to require costly intensive care, longer hospitalisation, and die from complications. Nations would thus find it extremely difficult to either lift or sustain socially, economically, and politically dama...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.110374
更新日期:2021-01-01 00:00:00
abstract::At present no good method of assisting the right ventricle of the heart exists. This paper presents a new and effective approach to assisting the right ventricle of the heart which can be utilized independently or during cardiac surgery. Through implementation of this method, and timed inflation and deflation of sever...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(79)90003-3
更新日期:1979-11-01 00:00:00
abstract::Oxygen therapy, usually administered by a facemask or nasal cannulae, is the current default treatment of respiratory failure. Since respiration entails intake of oxygen and release of carbon dioxide from tissues as waste product, the notion of administering carbon dioxide in respiratory failure appears counter-intuit...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.11.010
更新日期:2018-01-01 00:00:00
abstract::Cardiomyopathies are the group of diseases affecting the cardiac muscle. Although they have never been related to oxidative stress diseases, an analysis of the causes of these pathologies reveals the presence of a pro-oxidative agent or that the intracardiocytic balance between oxidation and antioxidation has been bro...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(96)90453-3
更新日期:1996-08-01 00:00:00
abstract::MS risk is associated with low vitamin D status prior to disease, and Epstein Barr virus (EBV) infection seems to be a prerequisite for MS. EBV could activate autoreactive T cells by several mechanisms, but it is not clear why this leads to MS. Only a small proportion of those infected with EBV develops MS, whereas au...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.04.030
更新日期:2008-01-01 00:00:00
abstract::The reluctance of physicians to get involved with child abuse can be attributed to the problem of role conflict. Physicians derive their social authority from the Aesculapian tradition. This form of social authority is fragile and easily subverted, yet of utmost importance if physicians are to retain their effectivene...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(82)90028-7
更新日期:1982-04-01 00:00:00
abstract::Cancer stem cells are a small population of tumor cells that have many malignant features such as chemotherapy resistance, radiotherapy resistance, tumorigenicity and are responsible for tumor progression, disease recurrence and metastasis. Therefore, insight into the regulation of the biology of cancer stem cells is ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.12.016
更新日期:2013-04-01 00:00:00
abstract::Timely recanalization of infarct related artery along with effective myocardial cell reperfusion represents a major challenge in the management of STEMI. The reperfusion of coronary arteries can induce further cardiomyocyte death by generating oxidative stress, which itself can mediate myocardial damage through a numb...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.03.010
更新日期:2017-05-01 00:00:00
abstract::Neuromyelitis optica (NMO) is an uncommon, life-threatening demyelinating disease that produces transverse myelitis and optic neuritis. An important pathogenetic mechanism belongs to NMO-IgG autoantibodies directed against the ultrastructure of the water channel aquaporin-4 (AQP4), the so-called orthogonal arrays of p...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.02.036
更新日期:2009-09-01 00:00:00
abstract::The concept of local pathology has long served neurology admirably. Relevant models include self-organizing nonlinear brain dynamics, global workspace and dynamic core theories. However such models are inconsistent with certain clinical phenomena found in Charles Bonnet syndrome, disjunctive agnosia and schizophrenia,...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.04.012
更新日期:2010-11-01 00:00:00
abstract::In elderly, the fractures in C1-C2 are a common entity. Poor bone quality and wide range of motion hamper the natural bone fusion, thus making surgery often the only possible way to deal with the underlying pathology. The proximity to important neurovascular structures represents the stabilization in this segment a ch...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109641
更新日期:2020-02-21 00:00:00