Abstract：
:A nutraceutical that has exploded onto the prescription pad in recent years is the fat soluble vitamin, vitamin D. This is due to an increasing medical interest in the utility of the vitamin in the treatment and prevention of an array of diseases and ailments. Despite the continued debate over the correct dose, form and serum levels, many clinicians fail to achieve intended therapeutic responses with their patients and deficiencies still exist. This may be due to medical professionals being less aware of the multitude of factors that can influence treatment when dosing a product. In this paper we explore the magnitude of interactions that exist between the host physiology and the vitamin and cite such points as a reason for confounding treatment end points. Aspects that are proposed to influence treatment success more critically than dose and molecular form prescribed are: organ pathology, intracellular states, the endocrine system, concomitant products, genetics, lifestyle, quality of product, and modern delivery systems.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Braithwaite MC,Kumar P,Tyagi C,Tomar LK,Choonara YE,Pillay Vdoi
10.1016/j.mehy.2013.07.022subject
Has Abstractpub_date
2013-10-01 00:00:00pages
656-63issue
4eissn
0306-9877issn
1532-2777pii
S0306-9877(13)00346-0journal_volume
81pub_type
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