Abstract:
:Cancer stem cells are a small population of tumor cells that have many malignant features such as chemotherapy resistance, radiotherapy resistance, tumorigenicity and are responsible for tumor progression, disease recurrence and metastasis. Therefore, insight into the regulation of the biology of cancer stem cells is important to eradicate cancer. Recently, studies suggested that hematopoietic stem cells could incorporate into tumor stroma and differentiated into stromal cells and the cells derived from hematopoietic stem cells play an important role on tumor progress. Moreover, cancer cells competed with hematopoietic stem cells for occupancy of the hematopoietic stem cell niches to regulate bone metastasis and most cancer cells in bone marrow metastasis were cancer stem cells. Therefore, we hypothesize that cancer stem cells could promote hematopoietic stem cells incorporating into tumor microenvironment and resulting into transformation of hematopoietic stem cells to stromal cells, which could impact the biological behavior of cancer stem cells.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Lin S,Fu Sdoi
10.1016/j.mehy.2012.12.016subject
Has Abstractpub_date
2013-04-01 00:00:00pages
494-7issue
4eissn
0306-9877issn
1532-2777pii
S0306-9877(12)00565-8journal_volume
80pub_type
杂志文章abstract::Can consciousness be understood as the ongoing active creation of information (of meaning)? 'Emergence', the central concept in this hypothesis, plays an essentially different role in it than in theories previously proposed. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(92)90023-6
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.02.003
更新日期:2017-04-01 00:00:00
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.03.042
更新日期:2013-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.08.045
更新日期:2011-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.05.037
更新日期:2017-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.08.045
更新日期:2006-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(92)90194-h
更新日期:1992-04-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.06.012
更新日期:2007-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.12.018
更新日期:2005-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(78)90004-x
更新日期:1978-05-01 00:00:00
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journal_title:Medical hypotheses
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.11.010
更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1982-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.04.009
更新日期:2012-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.11.001
更新日期:2018-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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