Immune reaction links disease progression in cancer patients with depression.

abstract：:Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play an essential role in tumor-associated immunosuppression, which hampers effective immunotherapeutic approaches. MicroRNAs (miRNAs) are short noncoding RNAs that negatively regulate target gene expression at the posttranscriptional level...

journal_title：Medical hypotheses

authors： Tian J,Rui K,Wang S

更新日期：2014-08-01 00:00:00

abstract：:Dietary chromium supplementation for the treatment of diabetes remains controversial. The prevailing view that chromium supplementation for glucose regulation is unjustified has been based upon prior studies showing mixed, modest-sized effects in patients with type 2 diabetes (T2DM). Based on chromium's potential to i...

journal_title：Medical hypotheses

authors： Brownley KA,Boettiger CA,Young L,Cefalu WT

更新日期：2015-07-01 00:00:00

abstract：:Acute disseminated encephalomyelitis (ADEM) is defined as a multifocal, monophasic, demyelinating, and inflammatory disease involving the central nervous system. It typically begins within 6 weeks of an antigenic challenge such as infection or immunization. Perivenous inflammation, edema and demyelination are the path...

journal_title：Medical hypotheses

authors： Sabayan B,Zolghadrasli A

更新日期：2007-01-01 00:00:00

abstract：:Patients with chronic kidney disease (CKD) experience co-morbid illnesses, including cardiovascular disease and retinopathy. Sevelamer hydrochloride (Renagel®); a non-calcium phosphate binder reduces coronary artery and aortic calcification as compared to calcium containing phosphate binders and additionally effects i...

journal_title：Medical hypotheses

authors： Draca N,Lazic R,Simic P,Dumic-Cule I,Luetic AT,Gabric N

更新日期：2013-04-01 00:00:00

abstract：:Chronic fatigue syndrome (CFS) has gained prominence since 1988 and a substantial amount of research has been done in this domain. However, it is still regarded as a controversial condition. Moreover, most of the symptoms of CFS itself are non-specific, occurring in many illnesses; some of the symptoms are also common...

journal_title：Medical hypotheses

authors： Van Hoof E,Cluydts R,De Meirleir K

更新日期：2003-07-01 00:00:00

abstract：:Dyslipidemia is a common pathology throughout the industrialized world, and HMG-CoA reductase inhibitors (statins) are often administered to treat elevated lipid levels. Substantial concern has been raised regarding the aggressive clinical lowering of cholesterol, particularly in light of a growing body of research li...

journal_title：Medical hypotheses

authors： Gendle MH

更新日期：2016-12-01 00:00:00

abstract：:Metformin, a drug widely used in the treatment of type II diabetes mellitus (T2DM), has been the focus of interest as a potential therapeutic agent for certain types of malignancies, including gynaecological cancers [i.e. endometrial cancer (EC)]. Although the exact mechanism behind the potential anticancer activity o...

journal_title：Medical hypotheses

authors： Karadeniz Z,Aynacıoğlu AŞ,Bilir A,Tuna MY

更新日期：2020-01-01 00:00:00

abstract：:Anorexia nervosa manifests a wide range of features which cannot fully be explained on the basis of socio-cultural pressures to be thin, nor by starvation, nor dehydration. Evidence is emerging of a significant neurobiological contribution to its aetiology. However there has to date been no explanation for its pathoge...

journal_title：Medical hypotheses

authors： Nunn K,Frampton I,Lask B

更新日期：2012-05-01 00:00:00

abstract：:Non-union after bone fracture is rather common with an increasing frequency of incidence rate due to poorly treated early operations, among which the mechanism of atrophic non-union remains unclear. Previous opinions showed that impaired blood supply of affected limbs might mostly contribute to the atrophic non-union,...

journal_title：Medical hypotheses

authors： Sun D,Yuan D,Zhang X

更新日期：2011-07-01 00:00:00

abstract：:In light of the progressive, pubertal increases in serum gonadotropin (FSH, LH) levels coinciding with the peak incidence of simple goiters; the common alpha subunits associated with the gonadotropins, TSH and hCG; the ability of LH and hCG to bind to thyroid TSH receptors and affect thyroid function; and, the probabl...

journal_title：Medical hypotheses

authors： DiNicola AF

更新日期：1983-04-01 00:00:00

abstract：:The cranial nerve rhizophathy, commonly presented with trigeminal neuralgia (TN) or hemifacial spasm (HFS), is a sort of hyperexcitability disorders with higher incidence in senior Asian. In this paper, a novel hypothesis on the pathogenesis is proposed and with which some clinical phenomena are explained. In those wi...

journal_title：Medical hypotheses

authors： Liu M,Zhong J

更新日期：2020-09-01 00:00:00

abstract：:Rett syndrome (RTT) is an X-linked dominant postnatal severe and disabling neurodevelopmental disorder which is the second most common cause for genetic mental retardation in girls and the first pervasive disorder with a known genetic basis. The syndrome is primarily caused by mutations in the Methyl CpG binding prote...

journal_title：Medical hypotheses

authors： Ben-Zeev B,Aharoni R,Nissenkorn A,Arnon R

更新日期：2011-02-01 00:00:00

abstract：:A five-step hypothesis on the pathogenesis of Hodgkin's disease (HD) is presented. Weak immune suppressor activity gives a predisposition for the development of the disease, after which a non-specific immune stimulation can initiate a self-perpetuating uncontrolled stimulation between interdigitating cells (IDCs), mac...

journal_title：Medical hypotheses

authors： Zwitter M

更新日期：1984-12-01 00:00:00

abstract：:Scrub typhus is a mite borne infectious disease which has re-emerged in India in the 3rd millennium after years of quiescence. In this review, the authors hypothesize the various factors responsible for resurgence of this disease. The main drivers that could have contributed to the upsurge in scrub typhus cases in pas...

journal_title：Medical hypotheses

authors： Ranjan J,Prakash JAJ

更新日期：2018-06-01 00:00:00

abstract：:In literature, the cerebellum is given a substantial role in cognitive processes, in addition to traditional views on cerebellar function of regulating motor behaviour. The phenomenon of cerebellar damage causing impairments in memory and executive functioning was observed in various cerebellar disorders. Cerebellar c...

journal_title：Medical hypotheses

authors： Wijnia JW,Goossensen A

更新日期：2010-08-01 00:00:00

abstract：:Breast and ovarian cancer rates in Pakistan are significantly higher than in neighboring countries. The cancer rate discrepancies cannot be explained with discrepancies of their risk factors. We propose that observed cancer excess in Pakistan is due to cancer development by negative heterosis. Heterosis occurs when a ...

journal_title：Medical hypotheses

authors： Denic S,Khatib F,Awad M,Karbani G,Milenkovic J

更新日期：2005-01-01 00:00:00

abstract：:Mucous membrane pemphigoid (MMP) is a subtype of autoimmune subepidermal blistering diseases characterized by autoantibodies to structural components of the hemidesmosome primarily affecting mucous membranes. Inflammation-related progressive scarring can lead to serious complications, including blindness, and the dise...

journal_title：Medical hypotheses

authors： Kasperkiewicz M,Płatkowska A,Zalewska A,Zillikens D

更新日期：2015-10-01 00:00:00

abstract：:In a previous paper we predicted that health effects of dietary fats in humans would require half a century or more to be understood, instead of the decade or so predicted during 1956 by an Editorial in The Lancet. It would seem that our prediction may have been optimistic since it has now been reported that trans uns...

journal_title：Medical hypotheses

authors： Booyens J,van der Merwe CF

更新日期：1992-04-01 00:00:00

abstract：:Although many risk factors influence atherogenesis, LDL appears to play a primary role in this process. In prospective epidemiology, coronary risk increases as LDL cholesterol increases, throughout the entire range of concentrations encountered in healthy humans. Coronary risk is minimal in individuals and populations...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2005-01-01 00:00:00

abstract：:Learning disability, attentional disorder and childhood major depression are frequent diagnoses in children with behavioral disturbances and impaired school performance. All three disorders are associated with right cerebral hemisphere dysfunction. Anatomical disturbance of right hemisphere function results in learnin...

journal_title：Medical hypotheses

authors： Brumback RA,Staton RD

更新日期：1982-05-01 00:00:00

abstract：:Fibromyalgia (FM) is a debilitating, widespread pain disorder that is assumed to originate from inappropriate pain processing in the central nervous system. Psychological and behavioral factors are both believed to underlie the pathogenesis and complicate the treatment. This hypothesis, however, has not yet been suffi...

journal_title：Medical hypotheses

authors： Hulens M,Dankaerts W,Stalmans I,Somers A,Vansant G,Rasschaert R,Bruyninckx F

更新日期：2018-01-01 00:00:00

abstract：:The new prion diseases that have emerged in the last 15 years are bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (variant CJD). Although initially confined to the UK, these diseases have recently emerged in other European countries. The accepted cause of the human disease is that BSE spre...

journal_title：Medical hypotheses

authors： Brown DR

更新日期：2001-11-01 00:00:00

abstract：:Infantile neuroaxonal dystrophy (INAD) and Duchenne muscular dystrophy (DMD) are two deadly neuromuscular degenerative diseases of childhood. Knowledge on their pathophysiological mechanisms may direct us towards treatment or a cure. Although these diseases are caused by two totally different gene-mutations and cause ...

journal_title：Medical hypotheses

authors： Offringa-Hup A

更新日期：2020-04-01 00:00:00

abstract：:There are large amounts of zinc in muscle and zinc ions can enhance the degree of muscle contraction in response to direct stimulation while at the same time inhibiting neuromuscular transmission. The opposites of these effects would lead to myotonia and muscle weakness. There are many parallels between the non-muscul...

journal_title：Medical hypotheses

authors： Horrobin DF,Morgan RO

更新日期：1980-04-01 00:00:00

abstract：:Inflammation integrates diverse mechanisms that are associated not only with pathological conditions, such as cardiovascular diseases, type 2 diabetes, obesity, neurodegenerative diseases and cancer, but also with physiological processes like reproduction i.e. oogenesis and embryogenesis as well as aging. In the curre...

journal_title：Medical hypotheses

authors： Aller MA,Arias N,Fuentes-Julian S,Blazquez-Martinez A,Argudo S,Miguel MP,Arias JL,Arias J

更新日期：2012-06-01 00:00:00

abstract：:Intrauterine growth retardation (IUGR) is associated with insulin resistance, non-insulin-dependent diabetes mellitus (NIDDM) and cardiovascular diseases in adulthood. Postnatal tissues contain stem cells that though quiescent, retain their capacity to self-renew and regenerate tissues to fulfil organ demands. I propo...

journal_title：Medical hypotheses

authors： Cianfarani S

更新日期：2003-09-01 00:00:00

abstract：:For a virus to survive and replicate in an organism, it must employ strategies to evade and misdirect the host's immune response. There is compelling evidence that the primary immunoevasive strategy utilized by the SARS virus, like influenza, is to inhibit its host's corticosteroid stress response. This is accomplishe...

journal_title：Medical hypotheses

authors： Wheatland R

更新日期：2004-01-01 00:00:00

abstract：:Melatonin is well recognized for its role as a potent antioxidant and is directly implicated in the free radical theory of aging [1] [Reiter RJ, Pablos MI, Agapito TT, Guerrero JM. Melatonin in the context of the free radical theory of aging. Ann N Y Acad Sci 1996;786:362-78]. Moreover, melatonin has been shown to ret...

journal_title：Medical hypotheses

authors： Yeager RL,Oleske DA,Sanders RA,Watkins JB 3rd,Eells JT,Henshel DS

更新日期：2007-01-01 00:00:00

abstract：UNLABELLED:The expression of consciousness and the site of memory storage within the brain are unknown despite over a century of intense empirical scrutiny. Recent anatomical studies show that human protoplasmic astrocytes form innumerable uniform polyhedral tessellating domains that are arranged three-dimensionally. T...

journal_title：Medical hypotheses

authors： Robertson JM

更新日期：2013-12-01 00:00:00

abstract：:Whether retroviral integration is a phenomenon specific to properties of the surrounding genomic region is a widely debated question. In this paper we attempt to enlight the involvement of genomic regions prone to DNA double strand breaks in such process, as well as the more general concept of genome plasticity concer...

journal_title：Medical hypotheses

authors： Guinet E,Mimaud V,Rossignol P,Hameau L,Benboudjema L,Jasmin C,Tovey MG,Bélec L,Lang MC

更新日期：2003-02-01 00:00:00