Myotonic dystrophy: a disease caused by functional zinc deficiency due to an abnormal zinc-binding ligand?

abstract：:Sickle cell anaemia confirms that minor mutations in protein sequence can have catastrophic effects. However, RNA transcription depends on polymerases that have low fidelity and introduce errors at a rate of 10(-5) substitutions/base synthesised. For many large proteins translation of these errors could result in sign...

journal_title：Medical hypotheses

authors： Sallie R

更新日期：2004-01-01 00:00:00

abstract：:Acute disseminated encephalomyelitis (ADEM) is defined as a multifocal, monophasic, demyelinating, and inflammatory disease involving the central nervous system. It typically begins within 6 weeks of an antigenic challenge such as infection or immunization. Perivenous inflammation, edema and demyelination are the path...

journal_title：Medical hypotheses

authors： Sabayan B,Zolghadrasli A

更新日期：2007-01-01 00:00:00

abstract：:Tumor cells have an absence or deficiency of mitochondrial superoxide dismutase. Superoxide is produced when hematoporphyrin derivative is exposed to visible light. A significant portion of the antitumor effect of porphyrin:light therapy is hypothesized to be mediated by superoxide. ...

journal_title：Medical hypotheses

authors： Peterson DA,McKelvey S,Edmondson PR

更新日期：1981-02-01 00:00:00

abstract：:As human society is mainly cooperative, it is not clear how antisocial personality disorder (APD) persists. The current explanation is that sociopaths are cheaters who maximize their fitness by taking advantages from others. Although this argument is valid, we show here that society also benefits from APD. We propose ...

journal_title：Medical hypotheses

authors： Miric D,Hallet-Mathieu AM,Amar G

更新日期：2005-01-01 00:00:00

abstract：:Arrhythmias is one of the leading causes of death in the world. Current antiarrhythmic drugs are limited by unsatisfactory efficacy and adverse effects such as proarrhythmias. Reentry mechanism plays an important role in persistence of arrhythmias. Reentry can only continue when reentry path-length is longer than card...

journal_title：Medical hypotheses

authors： Li LD,Zhang CT,Ruan L,Ni MK,Quan XQ

更新日期：2011-01-01 00:00:00

abstract：:Transient period represents the time window between the exposure and response to the given stimuli inflicting the stress on the host. However, this time window is unlikely to engage in variety of signaling to culminate drastic impact on the host cell rather it is evolutionary in its sense implying a slow process. But ...

journal_title：Medical hypotheses

authors： Kannan S

更新日期：2004-01-01 00:00:00

abstract：:Cancer and other diseases may be a natural biological event, the activities of which may be dependent on the constitution of the individual. Where fetal and embryonic cells are not diseased or faulty or defective, they may be useful as therapies against cancer and other diseases. ...

journal_title：Medical hypotheses

authors： Caesar G

更新日期：2002-05-01 00:00:00

abstract：:Recent studies using a combination of isotope and balance techniques have shown that, in the postabsorptive state, the human kidney contributes substantially to overall glucose production and consumption. The kidney may contribute as much as the liver to gluconeogenesis and play an important role in the counterregulat...

journal_title：Medical hypotheses

authors： Stumvoll M,Meyer C,Mitrakou A,Gerich JE

更新日期：1999-05-01 00:00:00

abstract：:Nearly two million people suffer traumatic brain injury in the US each year. These injuries alter adversely the metabolism of myelin, a major lipid material in brain, both in people and in experimental injuries of animals. A newly discovered and severe human neuropathy from copper deficiency provides evidence that som...

journal_title：Medical hypotheses

authors： Klevay LM

更新日期：2013-12-01 00:00:00

abstract：:Ebola virus (EBOV) infection is associated with modulation of cytokine expression in infected patients. EBOV has been shown to interact directly with immune cells (at minimum with macrophages and dendritic cells) and modulation of cytokine expression has also been observed in vitro, which is similar to that in vivo. T...

journal_title：Medical hypotheses

authors： Denner J

更新日期：2015-09-01 00:00:00

abstract：:Several studies have demonstrated the existence of morphological, biological, genetic and antigenic correlations between human and animal retroviruses. Furthermore, some agents of bovine and feline origin can also be considered useful comparative models for the pathogenetic study of human diseases such as leukaemia, a...

journal_title：Medical hypotheses

authors： Di Guardo G

更新日期：1989-07-01 00:00:00

abstract：:Gastroesophageal reflux (GER) and asthma have been linked, but the true nature of this relationship is incompletely understood. Most of the literature examining this association has implicated GER as the factor contributing to asthma. GER has also been linked to conditions of the upper airway like sinusitis and obstru...

journal_title：Medical hypotheses

authors： Turbyville JC

更新日期：2010-06-01 00:00:00

abstract：:The water proton spin lattice relaxation time of normal and tumorous tissues of human and radiosensitivity yield a linear relationship. ...

journal_title：Medical hypotheses

authors： Akber SF

更新日期：1995-06-01 00:00:00

abstract：:The concept of local pathology has long served neurology admirably. Relevant models include self-organizing nonlinear brain dynamics, global workspace and dynamic core theories. However such models are inconsistent with certain clinical phenomena found in Charles Bonnet syndrome, disjunctive agnosia and schizophrenia,...

journal_title：Medical hypotheses

authors： Globus GG,O'Carroll CP

更新日期：2010-11-01 00:00:00

abstract：:Cancer stem cells are presently viewed as carriers of the growth initiating potential, repopulation capability and drug resistance in tumors. However, many of these fundamental properties of cancer are host-related, modified by cell-cell interactions and/or dependent on angiogenesis. Indeed, it is well established tha...

journal_title：Medical hypotheses

authors： Rak J

更新日期：2006-01-01 00:00:00

abstract：:The menstrual cycle appears to have evolved in humans and some other species to improve reproductive efficiency by enabling progesterone production without the presence of the fetus. This phenomenon is termed spontaneous decidualization. Repeated menstruation is produced in modern women because of better general healt...

journal_title：Medical hypotheses

authors： Goldstuck ND

更新日期：2020-11-01 00:00:00

abstract：:Stress, in its many forms, is long associated with the etiology and course of schizophrenia. The mechanisms mediating the impacts of stress are not fully elucidated. Here it is proposed that stress induced cortisol alters kynurenic acid (KA) and quinolinic acid (QA) in the cortex and amygdala/striatum, respectively. T...

journal_title：Medical hypotheses

authors： Anderson G

更新日期：2011-01-01 00:00:00

abstract：:The rigid gas permeable contact lens (RGPCL) is an ideal choice to improve the corrective vision of patients with a high degree of refractive error, keratoconus and corneal transplantation. However, RGPCL fitting is not an easy work for those patients with extremely irregular corneal surface. Technicians or doctors of...

journal_title：Medical hypotheses

authors： Zhao F,Zhao G,Weijie F,Chen L

更新日期：2018-04-01 00:00:00

abstract：:Alpha-fetoprotein (AFP) serum levels in man have long been utilized as a tumor marker and as a birth defect screening agent in the clinical laboratory. Although the physiological role of AFP has remained obscure, the stereotypic carrier/transport function of a fetal counterpart to albumin has been attributed to this o...

journal_title：Medical hypotheses

authors： Dauphinée MJ,Mizejewski GJ

更新日期：2002-06-01 00:00:00

abstract：:The malignant cell, in vivo, metabolizes and respires anaerobically. For a good many years scientists have been aware of anaerobia being present in malignant growths. The prevailing opinion is that the malignant cell is able to remain viable in an anaerobic medium. This assumption is incorrect and is actually misleadi...

journal_title：Medical hypotheses

authors： White MW

更新日期：1992-12-01 00:00:00

abstract：:Neural tube defect (NTD) is more common among spontaneously aborted fetuses than in infants born in the third trimester, but there is no direct evidence that NTD-affected conceptuses, presenting at these two different gestational ages, are components of a single disease process. Evidence for homology is here presented...

journal_title：Medical hypotheses

authors： Machin GA

更新日期：1979-02-01 00:00:00

abstract：:Data on lymphocyte biology indicate that the humoral system of B-cells is specifically active with precise analogies at all mucosal levels. Might there be a corresponding function for T-lymphocytes at the cutaneous structure level? Certain physiological findings appear to suggest that the two main lymphocyte populatio...

journal_title：Medical hypotheses

authors： Franchi F,Seminara P,Montella F

更新日期：1981-09-01 00:00:00

abstract：:Natural objects, live and inanimate, actively maintain their entities by using their capacities (i.e., properties, internal resources, mechanisms, and experience) adequately to their needs. It is suggested that the principle of adequate function is a law of nature. ...

journal_title：Medical hypotheses

authors： Yabrov A

更新日期：1986-03-01 00:00:00

abstract：:A theoretical consideration of the relationship between plasma concentrations of calcium and parathyroid hormone suggests that the reported negative correlations between these variables in normal subjects and in patients with secondary hyperparathyroidism, and the positive correlation in patients with primary hyperpar...

journal_title：Medical hypotheses

authors： Walton RJ

更新日期：1977-01-01 00:00:00

abstract：:Parathyroid hormone (PTH) acts as a controller of bone remodeling and has influence on periodontal tissues. In addition to the well-established catabolic effects (activation of bone resorption) of PTH, it is recognized that the PTH intermittent administration has anabolic effects (promotion of bone formation). However...

journal_title：Medical hypotheses

authors： Vasconcelos DF,Vasconcelos AC

更新日期：2016-03-01 00:00:00

abstract：:The modified base 5-methylcytidine has been found in the DNA of a number of different eukaryotic cells where it occurs principally in the dinucleotide sequence -CmpG- which is present as a palindrome in double-strand nucleic acid molecules. There is considerable evidence to indicate and suggest that 5-methylcytosine s...

journal_title：Medical hypotheses

authors： Hawtrey AO,Ariatti M

更新日期：1984-10-01 00:00:00

abstract：:The affected individual of hair loss demands help, because hair is viewed as a sign of youth and good health. Nowadays treatment of alopecia includes drug therapy and hair transplantation. Some drugs may promote hair growth, at least temporarily, but the treatment is effective only in milder alopecia, instead of exten...

journal_title：Medical hypotheses

authors： Zhao J,Liu LQ,Wang YJ,Yang W,Geng WX,Wei J,Li LW,Chen FL

更新日期：2008-01-01 00:00:00

abstract：:It is generally accepted that a placebo in a standard, randomized, controlled trial (RCT), being an inert substance, cannot itself produce any effects. Yet, the magnitude of the placebo effect has increased remarkably in the last three decades. We propose that macroscopic information entanglement potentially explains ...

journal_title：Medical hypotheses

authors： Manek NJ,Tiller WA

更新日期：2011-10-01 00:00:00

abstract：:Recent evidence suggests that covalent modifications to the genomic platform in the brain, that is DNA and its surrounding histones, provide a stable potentially lifelong mechanism for remembrance. Consequently, the making and unmaking of memories is accessible through pharmacological manipulations of these modificati...

journal_title：Medical hypotheses

authors： Gavin DP,Chase KA,Sharma RP

更新日期：2011-07-01 00:00:00

abstract：:The incidence and prevalence of Crohn's disease (CD) among children in developed countries is extremely high. Although, dietary factors have long been implicated, to date no single causative element has been identified. Risks or benefits for CD from dietary elements would depend on their appropriate metabolism within ...

journal_title：Medical hypotheses

authors： K Amre D,G Seidman E

更新日期：2003-03-01 00:00:00