Abstract：
:Inflammation integrates diverse mechanisms that are associated not only with pathological conditions, such as cardiovascular diseases, type 2 diabetes, obesity, neurodegenerative diseases and cancer, but also with physiological processes like reproduction i.e. oogenesis and embryogenesis as well as aging. In the current review we firstly propose that the inflammatory response could recapitulate the phylogenia. In this way, highly conserved inflammatory mechanisms that play a main role in the evolutive development of different animal species, both invertebrates as well as vertebrates, are identified. Therefore, we also hypothesize that inflammation could represent a key tool used by nature to modulate organisms according to the environmental conditions in which these develop. Thus, inflammation could be the pathway by which the environmental factors could be related to the evolutionary development. If so, the diverse human chronic inflammatory diseases that nowadays the Western society suffer would represent the way for adapting to the abrupt changes in their lifestyle. Nonetheless, the distribution of the different pathological conditions varies in terms of intensity and magnitude among Western country populations depending on their genetic polymorphism. In this case, it should be considered that this set of diseases, distributed between all the individuals that constitute the Westernized society, would represent a true Social Inflammatory Syndrome whose final result is its remodeling. In this context, the use of inflammation by the Western society could represent the camouflaged expression of efficient mechanisms of evolution and development. In addition, if the different types of the inflammatory response involved in these diverse chronic pathological conditions could trace the biochemical origins of life, perhaps inflammation could represent an archaeological tool of unsuspected usefulness for understanding our own origin.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Aller MA,Arias N,Fuentes-Julian S,Blazquez-Martinez A,Argudo S,Miguel MP,Arias JL,Arias Jdoi
10.1016/j.mehy.2012.02.018subject
Has Abstractpub_date
2012-06-01 00:00:00pages
721-31issue
6eissn
0306-9877issn
1532-2777pii
S0306-9877(12)00084-9journal_volume
78pub_type
杂志文章,评审abstract：:Epoxides as reactive intermediates of estrogen metabolism have been considered to be potential precursors of the 2- and 4-hydroxy, catechol estrogens and even to be mutagenic/carcinogenic agents themselves. The labile nature of the intermediates has made proof of their existence difficult in natural biological conditi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.04.012
更新日期：2016-06-01 00:00:00
abstract：:Endogenous lectins of normal tissues can play a functional role in recognition processes and cell adhesion. These functions are areas of particular relevance to tumor growth and metastasis. Our initial results on endogenous lectins of different tumors lead to the working hypothesis that the pattern of endogenous lecti...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(85)90118-5
更新日期：1985-09-01 00:00:00
abstract：:Epidemiological findings on the relation between foods and colon cancer are inconsistent. Many, but far from all, found positive associations for meat and fat and negative ones for vegetables and fruits. Explanations so far have focused on direct biochemical conversions in the colon or transit time, but they remain un...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.0878
更新日期：2000-03-01 00:00:00
abstract：:It is suggested that chronic fatigue syndrome/fibromyalgia is caused by virus injury to the calcium channels leading to larger quantities than usual of calcium ions entering the striated muscle cells. Should this be true, then treatment with a calcium antagonist (CA) may possibly be of value. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(94)90049-3
更新日期：1994-07-01 00:00:00
abstract：:Dental caries, a bacterial process that results in the acidic destruction of tooth structure, has historically been managed by the mechanical excavation of diseased tooth structure and then restoration with a synthetic material. The mechanical excavation of the infected site is most commonly achieved by a dental handp...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.05.002
更新日期：2011-09-01 00:00:00
abstract：:The secretion of Follicle Stimulating Hormone by the pituitary gland is not regulated entirely by the negative feedback from gonadal steroids. There is ample evidence that the secretion of FSH is regulated by a non-steroidal hormone of gonadal origin termed "inhibin". Using a radioimmunoassay procedure, immunoreactive...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(84)90119-1
更新日期：1984-10-01 00:00:00
abstract：:Diabetes is a global public health challenge that imposes heavy burdens on communities and individuals. Metformin, the first-line medication for diabetes, has the superiority of reducing risk of macrovascular diseases, all-cause mortality and even possibly cancers. Recent observational studies, however, have demonstra...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.05.025
更新日期：2013-08-01 00:00:00
abstract：:Approximately 15 million Americans including over 5 million children suffer from asthma, the most common chronic disease in childhood. The prevalence of pediatric asthma has risen sharply over the past four decades, with the sharpest increases occurring in children younger than 6 years and in urban, predominantly mino...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.10.001
更新日期：2004-01-01 00:00:00
abstract：:High level contamination by natural and industrial sources of the alkali earth metal, barium (Ba) has been identified in the ecosystems/workplaces that are associated with high incidence clustering of multiple sclerosis (MS) and other neurodegenerative diseases such as the transmissible spongiform encephalopathies (TS...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.12.034
更新日期：2004-01-01 00:00:00
abstract：:Whether retroviral integration is a phenomenon specific to properties of the surrounding genomic region is a widely debated question. In this paper we attempt to enlight the involvement of genomic regions prone to DNA double strand breaks in such process, as well as the more general concept of genome plasticity concer...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00410-3
更新日期：2003-02-01 00:00:00
abstract：:Lactic acid produced by the malignant tumor is what keeps the malignancy going. Suppression or the removal of lactic acid is the prerequisite for any cancer treatment. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2000.1227
更新日期：2001-05-01 00:00:00
abstract：:Mental retardation is a progressive condition in Down syndrome: intelligence starts to decline linearly within the first year. This phenomenon could be related to the overproduction of a toxic compound, hydrogen sulfide. Indeed, a gene located on chromosome 21 controls the production of cystathionine-β-synthase, an en...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109289
更新日期：2019-10-01 00:00:00
abstract：:Encouraging results have been obtained with stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC). However, local control rates decrease in larger volume disease. Several studies have found a correlation between T stage or tumor volume and local progression-free survival. In man...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.01.001
更新日期：2012-04-01 00:00:00
abstract：:The purpose of this paper is to present a model for removing antidromically activated afferent input from cervically elicited neurogenic motor evoked potentials (nMEPs). nMEPs have recently been used clinically, purportedly for monitoring spinal cord motor function, during spine surgery. However, the nMEP response may...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(98)90201-8
更新日期：1998-02-01 00:00:00
abstract：:Computer algorithms can only produce seemingly random or pseudorandom numbers whereas certain natural phenomena, such as the decay of radioactive particles, can be utilized to produce truly random numbers. In this study, the ability of humans to generate random numbers was tested in healthy adults. Subjects were simpl...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.02.019
更新日期：2005-01-01 00:00:00
abstract：:A study of the strikingly low incidence of sudden infant death syndrome in Eastern countries revealed significant differences in infant handling thought to have an etiological bearing; therefore this writer suggested that adoption of certain Eastern methods of nursing may reduce the incidence of sudden infant death sy...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(97)90254-1
更新日期：1997-07-01 00:00:00
abstract：:The etiology of most kinds of dementia is still obscure and is probably multifactorial. We query whether excessive watching of television may contribute to the development of dementive processes for the following reasons: TV spectators are exposed to a mass of successive and rapid stimuli with little or no possibility...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(93)90128-d
更新日期：1993-11-01 00:00:00
abstract：:Trigeminal neuralgia is a painful condition that causes great discomfort. Although this disease has been known for more than 1000years, there is still no consensus on its underlying mechanism or treatment. Many hypotheses have been reported to explain the cause and nature of trigeminal neuralgia. These include theorie...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.01.008
更新日期：2017-03-01 00:00:00
abstract：:Placebo controlled trials in disease states as currently constituted are designed to show a drug "works" when in fact it may not. Efficacy of this type may be constructed in trials that demonstrate some marginal superiority of a drug over placebo in disease states that do not take into account any potentialities of th...
journal_title：Medical hypotheses
pub_type： 社论,历史文章,评审
doi：10.1016/j.mehy.2010.01.038
更新日期：2010-05-01 00:00:00
abstract：:In contrast to Geschwind, Behan and Galaburda (GBG) theory, there is strong evidence that inheritance through maternal line is responsible for the coexistence of asthma and left-handedness early in childhood. A new model that incorporates GBG's theory and maternal inheritance is proposed. This hypothesis suggests that...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00325-6
更新日期：2004-01-01 00:00:00
abstract：:Malignant hyperthermia (MH) is a rare myopathy inducing severe accident when carriers are exposed to triggering agents. MH susceptibility (MHS) is assessed by pharmacological tests performed on muscle strips. Exertional heat stroke (EHS) is a severe accident occurring during long and strenuous exercise. It has been ob...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(95)90116-7
更新日期：1995-09-01 00:00:00
abstract：:The weight of available evidence suggests that leukaemogenesis is a multi-step, complex process. Since there are different types of leukaemia, it seems likely that a variety of distinct molecular mechanisms are involved, arising from different combinations of genetic defects. It is not therefore surprising that studie...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(87)90188-5
更新日期：1987-03-01 00:00:00
abstract：:Chronic viral liver disease may evolve to cirrhosis. The medical treatment to slow down this passage is based on anti-viral and anti-fibrotic properties of interferon. Recently, we evidenced significant increase of portal vein flow velocity and volume after a prostacyclin analog (iloprost) infusion in subjects without...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.05.017
更新日期：2005-01-01 00:00:00
abstract：:Lack of vascularization results in increased demand for oxygen and creates a defined feature of the tumor microenvironment known as tumor hypoxia. It is well established that in response to hypoxia, hypoxia-inducible factor-1 α (HIF-1α) is induced which is an important factor in angiogenesis, invasion and metastasis. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110357
更新日期：2021-01-01 00:00:00
abstract：:Reconciling the early promising results of radiation therapy in the treatment of epilepsy with the recent theory concerning the role of nonsynaptic mechanisms in focal epileptogenesis, it is suggested that the potential of irradiation as an alternative to temporal lobe resection in intractable epilepsy should be re-ev...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(80)90102-4
更新日期：1980-05-01 00:00:00
abstract：:The prevalence of atopic diseases (atopic dermatitis, bronchial asthma, allergic rhinitis) has considerably increased for the last 40 years. This tendency has coincided with the beginning of the epoch of the use of the topical corticosteroids, which have a potent immunomodulation action. This fact itself as well as a ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.12.059
更新日期：2005-01-01 00:00:00
abstract：:Exercise is a key component for prevention and treatment of type 2 diabetes. However, diabetes complications affect exercise habits. Computerized clinical decision support systems (CCDSSs) may help specialists improve their decision-making abilities in the management of diseases. We hypothesized that patients' diabeti...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110070
更新日期：2020-10-01 00:00:00
abstract：:Too small size at birth (due to poor fetal growth and/or preterm delivery) has been associated with substantially elevated risks of the metabolic syndrome (dislipidemia, insulin resistance, hypertension), type 2 diabetes and cardiovascular disease in adulthood. The mechanisms of such "fetal origins" or "programming" o...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.08.020
更新日期：2006-01-01 00:00:00
abstract：:Non-invasive molecular analysis of fetal DNA is the diagnostic goal of prenatal medicine. Circulating fetal DNA can be detected in maternal plasma. Recently, it has been detected in the urine of pregnant women. We hypothesize that fetal DNA is present also in maternal saliva and that advances in stabilization and isol...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.09.022
更新日期：2010-02-01 00:00:00
abstract：:A neural network approach to modeling the development of personality traits through social learning is presented. From the more general model the special case of a network mapping four situation dimensions (input neurons) into seven dimensional personality traits (output neurons) is described. This network is allowed ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(93)90057-w
更新日期：1993-08-01 00:00:00
