Abstract:
:Anorexia nervosa manifests a wide range of features which cannot fully be explained on the basis of socio-cultural pressures to be thin, nor by starvation, nor dehydration. Evidence is emerging of a significant neurobiological contribution to its aetiology. However there has to date been no explanation for its pathogenesis that integrates the previously identified genetic, neurobiological and socio-cultural contributing factors. In this paper we propose an empirically-based hypothesis that genetically determined noradrenergic dysregulation, interacting with epigenetic factors, leads to high levels of anxiety, impaired neuroplasticity and regional cerebral hypoperfusion. These, in combination, lead to insula dysfunction. The resulting impairment in insula homuncular representation explains the pathognomonic body image distortion. This distortion, combined with high levels of body-focused anxiety, gives rise to intense dieting, noradrenergic precursor depletion, and initial reduction in anxiety. The subsequent rebound exacerbation of anxiety leads to a vicious cycle of maintenance. Novel treatment implications based on this hypothesis are briefly considered.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Nunn K,Frampton I,Lask Bdoi
10.1016/j.mehy.2012.01.033subject
Has Abstractpub_date
2012-05-01 00:00:00pages
580-4issue
5eissn
0306-9877issn
1532-2777pii
S0306-9877(12)00044-8journal_volume
78pub_type
杂志文章abstract::The German doctor Hermann Kümmell described Kümmell's disease as the clinical scenario in which patients suffer a trivial spinal trauma, but develop a symptomatic, progressive, angular kyphosis after a symptom-free period of months to years. Since an intravertebral vacuum phenomenon, which is considered indicative of ...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2011.08.005
更新日期:2011-11-01 00:00:00
abstract::Relapse to cocaine, heroin, and alcohol is a common occurrence in ex-abusers of these substances. Although there are many potential causes for relapse, we postulate that one cause in some people may be re-exposure in an anesthesia setting to a drug similar to the formerly abused drug. We hypothesize, for example, that...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1999.0797
更新日期:1999-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1998.0786
更新日期:1999-11-01 00:00:00
abstract::The initial treatment for hypotension due to blood loss is intravenous fluids. Occasionally there is need for additional medication, as well as stopping the source of the bleeding. The literature in the main discusses the use of dopamine. Ephedrine has not been reviewed as useful in such situations. This article discu...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(91)90242-q
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abstract::Howard Gardner identified five different kinds of creative activity among eminent creators, namely, solving a well-defined problem, putting forth a general conceptual scheme, creating a product that embodies ideas, stylized innovation of an art form, and a 'high-stakes' performance in the socio-political arena. In thi...
journal_title:Medical hypotheses
pub_type: 传,历史文章,杂志文章
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更新日期:1999-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.03.030
更新日期:2009-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1999.0852
更新日期:2000-03-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.05.030
更新日期:2016-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.110320
更新日期:2020-12-01 00:00:00
abstract::The favourable effects of eicosapentaenoic acid (EPA)- and doco-sahexaenoic acid (DHA)-rich diets (marine fish, fish oil) on several risk factors for cardiovascular disease are well established. The present survey describes possible new indications for diets supplemented with long-chain n-3 fatty acids. During a stand...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(91)90169-y
更新日期:1991-09-01 00:00:00
abstract::Insufficient attention has been given to reports in the literature describing patients with symptomatic migraine who, in addition to, or instead of, the well-recognized zones of hypofusion, have zones of hyperperfusion, which can be interpreted as hypermetabolism due to neuronal activation. A new neural theory of migr...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2000.1214
更新日期:2001-03-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2000.1232
更新日期:2001-03-01 00:00:00
abstract::Idiopathic intracranial hypertension (IHH or pseudotumor cerebri) is an uncommon but important cause of headache, characterized by raised intracranial pressure (ICP) in the absence of infection and intracranial pathology on neuroimaging. Lumbar puncture (LP) is usually contra-indicated in situations where the ICP is s...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1998.0756
更新日期:1999-10-01 00:00:00
abstract::Intestinal dysbiosis refers to an imbalance in the intestinal flora. The concept of small intestinal bacterial overgrowth (SIBO), a condition of abnormal proliferation of the small intestine microbiota, has been proposed as a form of small intestine dysbiosis. In Parkinson's disease patients, weight loss and metabolic...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109436
更新日期:2020-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.03.008
更新日期:2014-06-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.04.053
更新日期:2010-02-01 00:00:00
abstract::It has been uncovered that expansion of trinucleotide repeats in the human genome are causing a variety of genetic diseases. They are also identified in other loci that are not clearly related to particular diseases, which indicates such repeat expansion is one of the general forms of evolution occurring throughout th...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2000.1140
更新日期:2001-03-01 00:00:00
abstract::It is postulated that the induction of immunological tolerance to chemical carcinogens is due to the penetration of carcinogens and its albumin and DNA adducts from the maternal organism into the embryo. Maternal serum lgG-antibodies to carcinogens promote the transportation of carcinogens and adducts into the embryo ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2000.1393
更新日期:2001-07-01 00:00:00
abstract::Yawning is a stereotyped event that occurs in humans and animals from fish to mammals, but neither its mechanisms nor its functions are entirely known. Its widespread nature suggests that it has important physiological functions. It is associated with stretching of muscles in a large area, but the function of this str...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.06.027
更新日期:2008-01-01 00:00:00
abstract::Obesity is a major public health problem, which occurs in epidemic proportions. Our understanding of the systems of the brain related to energy balance has increased over the last decade. As a result, drugs most commonly used today in the management of obesity have their primary effect in modulating the balance betwee...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2003.12.030
更新日期:2004-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(95)90202-3
更新日期:1995-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(02)00260-8
更新日期:2002-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.04.070
更新日期:2006-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2012.01.036
更新日期:2012-05-01 00:00:00
abstract::The natural tibiofemoral joint (TFJ) functions according to the asymmetrical joint surfaces and the rolling-gliding mechanism. In the sagittal section, the human TFG is the tibial plateau on the medial concave side and curved on the lateral convex. With the asymmetrical joint surfaces, the flexion of the knee consists...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.04.015
更新日期:2014-09-01 00:00:00
abstract::The high prevalence of deleterious polygenic type 2 diabetes (T2D) is a paradox requiring explanation beyond food excess, inactivity and the obesity resulting from positive energy balance. Historically, hunting-foraging and later agrarian communities often manifested a converse negative energy balance due to nutrition...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.04.014
更新日期:2019-06-01 00:00:00
abstract::A mechanism of action for Panax ginseng (PG) and Eleutherococcus senticosus (ES) is proposed which explains how they could produce the paradoxical effect of sometimes increasing and sometimes decreasing the stress response. The mechanism suggests that this biphasic effect results from increased occupancy of positive a...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2000.1163
更新日期:2001-05-01 00:00:00
abstract::The hypothesis is proposed that: 1. Aflatoxin B1 and polycyclic hydrocarbon carcinogens bind to the regions of DNA to which steroid hormones bind and cause the deletion of genes in these regions. 2. The deletion of these genes may be responsible for a reduced number of ribosomes bound to the endoplasmic reticulum. 3. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(77)90063-9
更新日期:1977-07-01 00:00:00
abstract::Maintaining a body temperature within a narrow range is vital for the survival of all mammals, including humans. With the help of optogenetics, a better understanding of the thermoregulatory organs and pathways is achieved. Optogenetic activation of the GABAergic neurons in the ventral part of the lateral preoptic nuc...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109704
更新日期:2020-06-01 00:00:00
abstract::The per review system for the assessment of research proposals is widely respected by working scientists. Nevertheless two problems associated with the operation of this system by the US National Institutes of Health are identified. First the scientist has no control over which committee will review an application and...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(76)80019-9
更新日期:1976-01-01 00:00:00