Abstract：
:The available epidemiological data for amyotrophic lateral sclerosis (ALS) support an infectious etiology and lead us to propose a new hypothesis. We examined older epidemiological data concerning categories of the population with increased incidence (aged people, people living in rural areas, farmers, breeders), more recent epidemiological reports regarding Italian soccer players, AIDS patients, people living in highly polluted areas, and reports of cases of conjugal and pregnancy-associated ALS. The toxic and infectious hypotheses lead us to suggest a role for cyanobacteria in the production of endogenous beta-N-methylamino-L-alanine. Infection from a cyanobacterium, or another ubiquitous bacterium having similar characteristics, may be the missing clue to the etiology of ALS. We speculate that ubiquitous bacteria secreting toxic amino acids and "colonizing" tissues and organs in the human body might be the common element linking motor neuron diseases in Guam to sporadic ALS in the rest of the world.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Stipa G,Taiuti R,de Scisciolo G,Arnetoli G,Tredici MR,Biondi N,Barsanti L,Lolli Fdoi
10.1016/j.mehy.2006.04.070subject
Has Abstractpub_date
2006-01-01 00:00:00pages
1363-71issue
6eissn
0306-9877issn
1532-2777pii
S0306-9877(06)00430-0journal_volume
67pub_type
杂志文章abstract：:Studies on receptor stability suggest that functional conversion of adrenoceptors between alpha and beta can occur in mammalian myocardium due to variations in the environment such as temperature changes, pH or hormonal changes. If adrenoceptors of the respiratory system behave similarly, heat and water loss of airway...
journal_title：Medical hypotheses
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更新日期：1988-12-01 00:00:00
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journal_title：Medical hypotheses
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doi：10.1054/mehy.1999.0907
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journal_title：Medical hypotheses
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更新日期：2013-04-01 00:00:00
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更新日期：2001-02-01 00:00:00
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更新日期：1993-07-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2005-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.mehy.2012.05.011
更新日期：2012-09-01 00:00:00
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journal_title：Medical hypotheses
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更新日期：2020-10-01 00:00:00
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doi：10.1016/j.mehy.2006.09.061
更新日期：2007-01-01 00:00:00
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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更新日期：2007-01-01 00:00:00
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更新日期：2016-12-01 00:00:00
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更新日期：2020-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2014-07-01 00:00:00
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pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.01.033
更新日期：2012-05-01 00:00:00
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journal_title：Medical hypotheses
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更新日期：2005-01-01 00:00:00
