Abstract:
:The mechanism of dermatomyositis/polymyositis (DM/PM) is unknown. There are multiple probable trigger mechanisms. Internal malignancy is a specific trigger for some cases of DM/PM. It is known that there are marked changes in the extracellular matrix around tumors and that various fractions of depolymerized glycosaminoglycans enter the circulation. Circulating ECM fractions are known to incorporate in the extracellular matrix (ECM). Skin changes in DM include mucin formation, edema, and atrophy. These are not post inflammatory changes. These changes could be a consequence of the tumor's effect in the generalized ECM. Many factors influence ECM. Infections are another probable trigger for DM/PM. Infections induce extracellular matrix changes. It is likely that a role for infectious agents in DM/PM will eventually be defined. The drug D-penicillamine is also a trigger for DM/PM. Understanding the mechanism of any one trigger might aid in helping define other triggers. Four other cutaneous signs of internal malignancy can be explained by the mechanism used to explain DM/PM.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Stone OJdoi
10.1016/0306-9877(93)90033-msubject
Has Abstractpub_date
1993-07-01 00:00:00pages
48-51issue
1eissn
0306-9877issn
1532-2777pii
0306-9877(93)90033-Mjournal_volume
41pub_type
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
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pub_type: 社论
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pub_type: 杂志文章,评审
doi:10.1054/mehy.2000.1094
更新日期:2001-01-01 00:00:00
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journal_title:Medical hypotheses
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更新日期:2014-05-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(80)90010-9
更新日期:1980-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(88)90060-6
更新日期:1988-06-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章,评审
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.01.052
更新日期:2009-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:1995-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.07.021
更新日期:2013-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109483
更新日期:2020-02-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.07.037
更新日期:2007-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:1999-05-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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