Important role of the kidney in human carbohydrate metabolism.

abstract：:Individuals with Down syndrome have signs of possible brain damage prior to birth. In addition to slowed and reduced mental development, they are much more likely to have cognitive deterioration and develop dementia at an earlier age than individuals without Down syndrome. Some of the cognitive impairments are likely ...

journal_title：Medical hypotheses

authors： Thiel R,Fowkes SW

更新日期：2005-01-01 00:00:00

abstract：:A hypothesis is suggested, which emphasizes the role in carcinogenesis of the attack on low molecular nucleophilic substances (LMN) by electrophilic agents - chemical carcinogens, phisical factors, and antitumor alkylating agents. The significance of the degree of nucleophilicity (electronic charge, order of bonds, in...

journal_title：Medical hypotheses

authors： Raikov ZD,Christova-Georgieva NI,Raikova ET

更新日期：1987-01-01 00:00:00

abstract：:Goldberger discovered human pellagra was a non-infectious disease, affecting mostly the small and the timid in overcrowded institutions. Symptoms were diarrhoea, dermatitis and dementia. The staff and older children escaped the disease. They ate the meat and left the small and timid with the gravy. The 'Goldberger syn...

journal_title：Medical hypotheses

authors： Reid G

更新日期：1993-05-01 00:00:00

abstract：:The prevailing view of lung cancer is multi-step progression of normal cells into cancer cells through gain of function oncogenes coupled with loss of tumor suppressor genes. This progression of genetic damage ultimately results in the hallmarks of cancer. This theory has strong support from studies finding genetic da...

journal_title：Medical hypotheses

authors： Haura EB

更新日期：2006-01-01 00:00:00

abstract：:The present analysis addresses the question of how it has been possible for academic medicine to grow and lose its creative productivity at the same time. A mathematical model is developed to simulate the mechanisms that govern growth of medical systems over time. Time-dependent growth of system size increases the occ...

journal_title：Medical hypotheses

authors： Sonnenberg A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Bipolar disorder (BD) is characterized by recurrent episodes of mood dysregulations and depression is considered as the most frequent form of relapse. However, there is some evidence that in tropical countries, the course might be different with fewer depressive episodes. This study aims to examine the frequ...

journal_title：Medical hypotheses

authors： Narayanaswamy JC,Moily N,Kubendran S,Reddy YC,Jain S

更新日期：2014-09-01 00:00:00

abstract：:The ability of tumor cells to differentiate in combination with their ability to express genes that are not expressed in normal tissues, may result in the emergence of new cell types in evolution. Tumors may play an evolutionary role by providing conditions (space and resources) for the expression of newly evolving ge...

journal_title：Medical hypotheses

authors： Kozlov AP

更新日期：2010-01-01 00:00:00

abstract：:Hypotheses regarding the factors that predispose individuals to developing AIDS after exposure to HTLV-III/LAV are beginning to emerge. It is suggested here that surgical removal of tonsils in childhood may increase the risk of developing opportunistic infections after infection with this newly discovered retrovirus. ...

journal_title：Medical hypotheses

authors： McCombie SC

更新日期：1986-03-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, with increasing incidence and prevalence in the last one-half century. IBD patients suffer from autonomic vagal neuropathy and nerve dysfunction, with deficiency of acetylcholine in inflamed mucosa. Recent studies showed that death of enteric neuron ...

journal_title：Medical hypotheses

authors： Guo Y,Lu N,Bai A

更新日期：2012-11-01 00:00:00

abstract：:Physiological levels of estrogen would seem to have a possible protective effect on hearing function and estrogen replacement therapy may delay hearing loss in menopausal women. Treatment of healthy menopausal women with Tibolone for 6 months resulted in improvement in audiometry results at low frequencies which was m...

journal_title：Medical hypotheses

authors： Köşüş N,Köşüş A,Turhan NÖ

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is the most common cardiac arrhythmia. Many studies have investigated the cause for the development of AF, however, the question remains unanswered. METHODS:A comparison of hydrodynamics between AF and sinus rhythm was performed. RESULTS:I proposed the hypothesis that atrial fibril...

journal_title：Medical hypotheses

authors： Tilman V

更新日期：2016-01-01 00:00:00

abstract：:Autism may be a disorder linked to the disruption of the G-alpha protein, affecting retinoid receptors in the brain. A study of 60 autistic children suggests that autism may be caused by inserting a G-alpha protein defect, the pertussis toxin found in the DPT vaccine, into genetically at-risk children. This toxin sepa...

journal_title：Medical hypotheses

authors： Megson MN

更新日期：2000-06-01 00:00:00

abstract：:Interleukin (IL)-17 is a pro-inflammatory cytokine originally described in T lymphocytes. Increased production of IL-17 has been linked to the induction of cytokines, chemokines and adhesion molecules in various cell types, effects that likely contribute to a number of inflammatory diseases including rheumatoid arthri...

journal_title：Medical hypotheses

authors： Csiszar A,Ungvari Z

更新日期：2004-01-01 00:00:00

abstract：:The 'Big Bang' is used to describe the origin of the Universe. While such an event could not create itself the expression is graphic. Tissue damage, traumatic, thermal, chemical; bites; insect, animal or human are all bad, but also well known factors which favor and initiate pathogenic activity. Antedating and outrank...

journal_title：Medical hypotheses

authors： Baggot MG

更新日期：1991-06-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder, characterized by loss of dopaminergic neuromelanin containing neurons in the substantia nigra. Peripheral melanin, found in skin and hair, and neuromelanin appear to have some characteristics in common and share the same precursor for their synthesis; therefore...

journal_title：Medical hypotheses

authors： Jucevičiūtė N,Banaitytė I,Vaitkus A,Balnytė R

更新日期：2019-06-01 00:00:00

abstract：:The modified base 5-methylcytidine has been found in the DNA of a number of different eukaryotic cells where it occurs principally in the dinucleotide sequence -CmpG- which is present as a palindrome in double-strand nucleic acid molecules. There is considerable evidence to indicate and suggest that 5-methylcytosine s...

journal_title：Medical hypotheses

authors： Hawtrey AO,Ariatti M

更新日期：1984-10-01 00:00:00

abstract：:Calcification is the most characteristic pathologic feature of healed meconium peritonitis. Occurrence of calcification in meconium peritonitis has been reported, but its mechanism has not been discussed. According to our studies, the cause of calcification and giant cell reaction is meconium peritonitis is related to...

journal_title：Medical hypotheses

authors： Forouhar F

更新日期：1984-05-01 00:00:00

abstract：:Intrinsic radio-sensitivity is the determinant of differential response of tumours to low LET ionising radiations. The probabilistic DNA fibril both model shows intrinsic radio-sensitivity factor [I] as function of nuclear diameter (Nd) and intra cellular hydrogen ion concentration [H+]. Linking probabilities of letha...

journal_title：Medical hypotheses

authors： Mohammed SA

更新日期：2013-12-01 00:00:00

abstract：:We describe a new term: glutamate-based depression (GBD). GBD is defined as a chronic depressive illness associated with environmental stress and diseases associated with altered glutamate neurotransmission. We hypothesize that glutamate-induced over-activation of extrasynaptic NMDA receptors in the subgenual cingulat...

journal_title：Medical hypotheses

authors： McCarthy DJ,Alexander R,Smith MA,Pathak S,Kanes S,Lee CM,Sanacora G

更新日期：2012-05-01 00:00:00

abstract：:The characteristic insoluble, senile (neuritic) plaques found extracellularly in brains of patients with Alzheimer's disease (AD) contain the fibrillar form of beta-amyloid (Abeta42). A substantial proportion of autopsied elderly brains have demonstrated DNA evidence of herpes simplex virus type 1 (HSV-1) infiltration...

journal_title：Medical hypotheses

authors： Kammerman EM,Neumann DM,Ball MJ,Lukiw W,Hill JM

更新日期：2006-01-01 00:00:00

abstract：:Cancer is a tissue that requires a genetic program, possibly involving hundreds of genes, as indicated by studies of differential gene expression performed with microarrays in various types of cancer. Cancer is thus a biological process of considerable precision as described by Schrödinger's equation, and it is not si...

journal_title：Medical hypotheses

authors： Garcia-Garcia A

更新日期：2009-04-01 00:00:00

abstract：:The constant level of various proteins including albumin and cellular components in intravascular pool in vivo is strictly controlled by an unknown homeostatic mechanism, although there are fluctuations seen in pathologic conditions. Because the majority of the IgG in the serum is regarded as self-reactive natural aut...

journal_title：Medical hypotheses

authors： Lee KY,Lee JS

更新日期：2006-01-01 00:00:00

abstract：:Dupuytren's disease is a pathological condition of the palmar fascia characterized by the formation of contractile disease cords that result in permanent finger contracture. This condition is believed to progress from a myofibroblast-rich nodule in the early clinical stages of the disease to a contractile disease cord...

journal_title：Medical hypotheses

authors： Vi L,Gan BS,O'Gorman DB

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Operative risk prediction systems (logistic EuroSCORE I, EuroSCORE II and STS Score) are employed together with multidisciplinary discussion to contraindicate conventional surgery in patients with valvular heart disease and propose the employment of alternative transcatheter procedures. The EuroSCORE I has b...

journal_title：Medical hypotheses

authors： Anselmi A,Ruggieri VG,Harmouche M,Mascle S,Auffret V,Le Breton H,Beneux X,Verhoye JP

更新日期：2015-05-01 00:00:00

abstract：:The repair and reconstruction of tissue defects and organ loss are severe problems, and many patients are eager to find avenues to these matters. Up until now, the number of methods used to repair tissue defects has increased, but all of these have their own advantages and inconveniences, and do not seem to have been ...

journal_title：Medical hypotheses

authors： Yang M,Liu L

更新日期：2008-01-01 00:00:00

abstract：:Submagnetic domain magnetic fluid particles of approximately 10 nm average diameter complexed with CD4 or monoclonal antibody and then injected into the patient, will localize to the cell membrane of the target cell. These ferrofluid particles will interact with an externally applied rotating magnetic field of rapidly...

journal_title：Medical hypotheses

authors： Peasley KW

更新日期：1996-01-01 00:00:00

abstract：:Melatonin is well recognized for its role as a potent antioxidant and is directly implicated in the free radical theory of aging [1] [Reiter RJ, Pablos MI, Agapito TT, Guerrero JM. Melatonin in the context of the free radical theory of aging. Ann N Y Acad Sci 1996;786:362-78]. Moreover, melatonin has been shown to ret...

journal_title：Medical hypotheses

authors： Yeager RL,Oleske DA,Sanders RA,Watkins JB 3rd,Eells JT,Henshel DS

更新日期：2007-01-01 00:00:00

abstract：:A hypothesis is presented concerning the origin of the action of muscles in the human and animal bodies It is advanced that muscle action originates with very rapid chemical reactions known as percussion reactions. These give rise to the temporary precipitation of solids in muscle cells. The accompanying volume change...

journal_title：Medical hypotheses

authors： Robertson DS

更新日期：2002-08-01 00:00:00

abstract：:Fulminant hepatitis is associated with an 80% mortality rate. Surviving patients do not develop chronic liver disease. Failure to produce adequate amounts of interferon and to achieve an antiviral state seem to be the basic defects in this condition. Tumor necrosis factor (TNF) has been shown to be induced by viruses....

journal_title：Medical hypotheses

authors： Aderka D,Levo Y

更新日期：1988-11-01 00:00:00

abstract：:The mechanism of pathogenesis of idiopathic Parkinson's disease (PD) is unknown. In a study of 200 PD patients and 200 age- and sex-matched controls, Strang noted a marked and statistically significant higher incidence of ulcers (diagnosed by X-ray or surgery) in the PD patients compared to the controls (14% to 4%). T...

journal_title：Medical hypotheses

authors： Altschuler E

更新日期：1999-07-01 00:00:00