Why does tonsillar herniation not occur in idiopathic intracranial hypertension?

abstract：:Most cancer cells differ from normal cells in that they show higher beta-glucuronidase activity and lower pH of their cytoplasm. Anti-cancer drugs can be designed which take advantage of these gradients to deliver maximal toxicity to tumors and minimal toxicity to normal tissue. Many design criteria are suggested here...

journal_title：Medical hypotheses

authors： Rubin DM,Rubin EJ

更新日期：1980-01-01 00:00:00

abstract：:The role of ozone on earth is controversial, as in the stratosphere it is protective against excessive ultra violet irradiation, and in the troposphere it is toxic for animals and plants. The effectiveness of ozone against pathogens is well recognized and ozone appears to be the best agent for sterilization of water. ...

journal_title：Medical hypotheses

authors： Bocci V

更新日期：1996-02-01 00:00:00

abstract：:Bony abnormalities are common findings in cases of neurofibromatosis 1. We might hypothesize that neurofibromin, the protein encoded by the neurofibromatosis 1 gene, plays important roles in bone development. Loss of function of oligodendrocyte-myelin glycoprotein gene and increased activity of ras p21 might increase ...

journal_title：Medical hypotheses

authors： Abdel-Wanis ME,Kawahara N

更新日期：2003-04-01 00:00:00

abstract：:Organisms release their antigens into the environment. Some antigens are volatile and may pass into the blood of other organisms during respiration. Fetal antigens enter the mother's bloodstream through the placenta. Foreign antigens in the blood can cause various chemical changes and may initiate an immune reaction. ...

journal_title：Medical hypotheses

authors： Rumyantsev SN,Grzeszczuk J

更新日期：1995-07-01 00:00:00

abstract：:Incidental pituitary adenoma is the common finding during brain imaging. According to multistep model of pituitary tumourigenesis genetic alterations provide the initiating event that transforms cells while hormones play a role in promoting cell proliferation. Development of pituitary adenoma in a case of excessive hy...

journal_title：Medical hypotheses

authors： Kastelan D,Korsic M

更新日期：2007-01-01 00:00:00

abstract：:Trigeminal neuralgia (TN) is a rare form of neuropathic pain that results in sudden, unilateral and recurrent pains in the distribution of one or more branches of the trigeminal nerve. The aetiology of TN remains unclear and several theories have been proposed. Many medical and surgical methods have been applied with ...

journal_title：Medical hypotheses

authors： Collet C,Haen P,Laversanne S,Brignol L,Thiéry G

更新日期：2013-12-01 00:00:00

abstract：:Autism, an incurable neurodevelopmental brain disorder, is a complex psychopathology in which the affected individual cannot effectively self-regulate their sensory inputs toward coherent and focused motor outputs. There have been many hypotheses as to the etiology of autism - genetics, neurotransmitter imbalances, ea...

journal_title：Medical hypotheses

authors： Buehler MR

更新日期：2011-06-01 00:00:00

abstract：:The number of patients with diabetes has been expected around 300 million by 2025 and 366 million by 2030 by WHO. On the other hand, diabetic wounds as one of the common complications of diabetes represent major health challenges. Recently, wound care biological products have been proposed for treatment of chronic wou...

journal_title：Medical hypotheses

authors： Larijani B,Ghahari A,Warnock GL,Aghayan HR,Goodarzi P,Falahzadeh K,Arjmand B

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Short-term acute care public county hospitals in the US were a mainstay of much "safety net" medical care in the early twentieth century. The private sector currently provides much of what was in the past public medical care. Does this transition affect health care indices? METHODS:The presence of public ho...

journal_title：Medical hypotheses

authors： Shandera WX

更新日期：2019-11-01 00:00:00

abstract：:Exacerbation of certain medical conditions during specific phases of the menstrual cycle has long been recognized. Mechanisms of the cyclic variations are poorly understood, but are often attributed to fluctuations in reproductive hormones. We hypothesize that normal variations in autonomic balance during the menstrua...

journal_title：Medical hypotheses

authors： Lee PY,Bazar KA,Yun AJ

更新日期：2004-01-01 00:00:00

abstract：:Recently, the metabolic routes for acetone metabolism have been described. Therefore, acetone cannot further be regarded as a waste product of metabolism. However, its physiological role in biochemical machinery is not clear. Here, an integrative model for the role of acetone metabolism is presented that orders the ev...

journal_title：Medical hypotheses

authors： Kalapos MP

更新日期：1999-09-01 00:00:00

abstract：:Dysbiosis is a prominent feature of inflammatory bowel diseases (IBD). However, the efficacy of using antibiotics aiming at the aberrant gut microflora for IBD treatment are either unsuccessful or not persistent. In contrast, long-term oral vancomycin has been proved effective in controlling both the bile duct and gut...

journal_title：Medical hypotheses

authors： Du W,Han W,Dong J

更新日期：2020-11-01 00:00:00

abstract：:The lymphatic system is an important component of human health and is critical in maintaining microcirculatory flow and immune system homeostasis. During septic shock, increased capillary permeability results in excess filtration of intravascular fluid and solutes producing interstitial edema with subsequent hydrostat...

journal_title：Medical hypotheses

authors： Pruitt LG

更新日期：2020-09-01 00:00:00

abstract：:The aetiology of multiple sclerosis suggests that its occurrence depends on a combination of factors, including viral infection in early childhood, genotype and an initiating event within the central nervous system. The resulting damage may be caused by events initiated by free radicals. Free radicals themselves may c...

journal_title：Medical hypotheses

authors： Cooper RL

更新日期：1997-10-01 00:00:00

abstract：:Herein it is hypothesized that M2-like macrophages or pre-macrophages of fetal origin might play a central role in development and closure of the neural tube. Early in embryonic development, pre-macrophages arise from the fetal yolk sac and track through the bloodstream to reach diverse embryonic tissues, where they m...

journal_title：Medical hypotheses

authors： Block J

更新日期：2019-08-01 00:00:00

abstract：:Learning disability, attentional disorder and childhood major depression are frequent diagnoses in children with behavioral disturbances and impaired school performance. All three disorders are associated with right cerebral hemisphere dysfunction. Anatomical disturbance of right hemisphere function results in learnin...

journal_title：Medical hypotheses

authors： Brumback RA,Staton RD

更新日期：1982-05-01 00:00:00

abstract：:There is a striking resemblance, in amino-acid composition and properties, between one class of structural glycoproteins from connective tissue and the apo low density lipoproteins (LDL) of blood plasma. It is suggested that there is a structurally specific analogy between the early atherogenic accumulation of LDL (an...

journal_title：Medical hypotheses

authors： Bowness JM

更新日期：1976-09-01 00:00:00

abstract：:Encouraging results have been obtained with stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC). However, local control rates decrease in larger volume disease. Several studies have found a correlation between T stage or tumor volume and local progression-free survival. In man...

journal_title：Medical hypotheses

authors： Nieder C,Andratschke N

更新日期：2012-04-01 00:00:00

abstract：:Information about the etiology of pressure sores has been contradictory and is inconsistent with the idea that pressure sore formation is due extensively to depriving a tissue region of blood. Based on these observations and on studies done in the cooperating laboratories, an hypothesis has been formulated that integr...

journal_title：Medical hypotheses

authors： Krouskop TA

更新日期：1983-06-01 00:00:00

abstract：:This paper discusses a mechanism for converting heterochromatin into the more relaxed state of euchromatin. Actuation of such state conversion stems from disassembly of internal vesicles that are incapable of surviving when trapped within the inner chamber of mammalian nuclei. ...

journal_title：Medical hypotheses

authors： Matioli GT

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Operative risk prediction systems (logistic EuroSCORE I, EuroSCORE II and STS Score) are employed together with multidisciplinary discussion to contraindicate conventional surgery in patients with valvular heart disease and propose the employment of alternative transcatheter procedures. The EuroSCORE I has b...

journal_title：Medical hypotheses

authors： Anselmi A,Ruggieri VG,Harmouche M,Mascle S,Auffret V,Le Breton H,Beneux X,Verhoye JP

更新日期：2015-05-01 00:00:00

abstract：:Irritable Bowel Syndrome (IBS) is a condition that may be marked by abdominal pain, bloating, fullness, indigestion, belching, constipation and/or diarrhea. IBS symptoms can result from malabsorption of fructose. Fructose is a monosaccharide found naturally in small quantities in fruits and some vegetables, and in muc...

journal_title：Medical hypotheses

authors： DiNicolantonio JJ,Lucan SC

更新日期：2015-09-01 00:00:00

abstract：:This hypothesis would help to elevate safety in nanogold-therapy of some cancers. It has no previous record in published media and there is no existing protocol for what is expressed in this paper. The hypothesis makes some experimental recommendations for future research at the interface of nanotechnology and biologi...

journal_title：Medical hypotheses

authors： Bonjar LS

更新日期：2013-05-01 00:00:00

abstract：:A case-control study was conducted in order to test the hypothesis that a reduced exposure to human seminal factors in the early reproductive life of women is a risk factor in breast cancer. The relative risk of exposure to the hypothetical semen-factor deficiency is 4.7 times greater for breast-cancer patients than f...

journal_title：Medical hypotheses

authors： Gjorgov AN

更新日期：1978-03-01 00:00:00

abstract：:Superficial fraying, splitting and fibrillation of articular cartilage as a consequence of ageing or mechanical injury is not always associated with joint pain. However, similar cartilage lesions accompanied by synovitis and engorgement of the subchondral vasculature generally is; the disorder being known as osteoarth...

journal_title：Medical hypotheses

authors： Ghosh P,Smith M

更新日期：1993-08-01 00:00:00

abstract：:For many years there was a general belief that the enzyme renin, having been secreted into the circulation by the kidney in response to appropriate stimuli, initially generates the inactive decapeptide angiotensin I in the bloodstream. This is then converted to the biologically active octapeptide angiotensin II by ang...

journal_title：Medical hypotheses

authors： Duckworth AJ,Goodship AE,Kendall HJ,Osborn EC

更新日期：2001-04-01 00:00:00

abstract：:For a virus to survive and replicate in an organism, it must employ strategies to evade and misdirect the host's immune response. There is compelling evidence that the primary immunoevasive strategy utilized by the SARS virus, like influenza, is to inhibit its host's corticosteroid stress response. This is accomplishe...

journal_title：Medical hypotheses

authors： Wheatland R

更新日期：2004-01-01 00:00:00

abstract：:The non-invasive assessment of chronic tissue hypoxia is difficult. Pulse oximetry only allows the peripheral oxygen saturation to be measured, while the detection of hyperlactataemia needs to take into account the fact that the accumulation of lactic acid may result from several causes other than prolonged tissue hyp...

journal_title：Medical hypotheses

authors： Puri BK,Monro JA

更新日期：2018-03-01 00:00:00

abstract：:Nasopharyngeal angiofibroma is a histologically benign tumor composed of stroma and vessels. The vascular component of the lesion is prone to bleeding and responsible for its clinical "malignancy". Some nasopharyngeal angiofibromas are resistant to surgical therapy because of extensive growth and occasionally bone des...

journal_title：Medical hypotheses

authors： Krstulja M,Car A,Bonifacić D,Braut T,Kujundzić M

更新日期：2008-01-01 00:00:00

abstract：:Extracts of the unripe fruit of Momordica charantia--bitter melon, which flourishes throughout the tropics--appear to have utility in the management of type 2 diabetes. Rodent studies suggest that the thus-far-uncharacterized active components of such extracts enhance the efficiency of postprandial glucose storage in ...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2004-01-01 00:00:00