Abstract：
:Through the analysis of accumulated experimental data of cell growth, a model of unrestricted cell growth is presented here. This model is based hypothetically on the cellular commitment to senescence as in the previously presented commitment theory. Cells are divided into 3 types, namely uncommitted cells, committed cells and terminal cells. The division of an uncommitted cell produces an uncommitted cell itself and a committed cell of the first generation. This committed cell goes through a limited number of cell divisions until the cells become non-dividing terminal cells. It is hypothesized that during a committed cell division, there is a very small probability that an uncommitted cell may be generated. With computer simulations, it is estimated that a committed cell of the first generation may divide around 30 times until they become non-dividing terminal cells, and that the probability of an uncommitted cell regeneration for each committed cell division may be 2(-H). This hypothesis may possibly clarify some aspects of the biological phenomena of cell growth, which can not be explained by the previous commitment theory, such as the growth pattern of cultured diploid cells, cancer initiation and promotion, and cancer progression and metastasis.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Tsuboi K,Hatabu H,Lee K,Nio Y,Tobe T,Hatanaka Mdoi
10.1016/0306-9877(92)90034-akeywords:
subject
Has Abstractpub_date
1992-08-01 00:00:00pages
355-63issue
4eissn
0306-9877issn
1532-2777pii
0306-9877(92)90034-Ajournal_volume
38pub_type
杂志文章abstract：:Following the rate of proteoglycan synthesis as the metabolic parameter of the growth of cartilage cells, indicates that hormonal and local agents are two distinct types of extracellular regulators responsible for altering the basic metabolic rates of cells. Such changes in growth rate occur regularly at physiological...
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2012-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1998.0740
更新日期：1999-09-01 00:00:00
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