On monosegmental sister chromatid exchanges (SCE).

abstract：:Trigeminal neuralgia (TN) is a rare form of neuropathic pain that results in sudden, unilateral and recurrent pains in the distribution of one or more branches of the trigeminal nerve. The aetiology of TN remains unclear and several theories have been proposed. Many medical and surgical methods have been applied with ...

journal_title：Medical hypotheses

authors： Collet C,Haen P,Laversanne S,Brignol L,Thiéry G

更新日期：2013-12-01 00:00:00

abstract：:It is universally accepted that the use of antibiotics will lead to antimicrobial resistance. Traditionally, the explanation to this phenomenon was random mutation and horizontal gene transfer and amplification by selective pressure. Subsequently, a second mechanism of antibiotic-induced antimicrobial resistance acqui...

journal_title：Medical hypotheses

authors： Woo PC,To AP,Lau SK,Yuen KY

更新日期：2003-10-01 00:00:00

abstract：:It is well known, that most of the psychiatric diseases affect various neurotransmitter systems. It is the aim of this profile to define a set of cheap analyses, indicative for a specific psychiatric disease, to facilitate differential diagnosis and to offer an additional tool to the already existing clinical-descript...

journal_title：Medical hypotheses

authors： Niederhofer H

更新日期：2011-10-01 00:00:00

abstract：:Acute viral infection is characterised by high-level replication before prompt decline of viraemia and, commonly, viral clearance. This kinetic pattern is generally held to be due to immune control. However, infection with some viruses, notably hepatitis C (HCV), hepatitis B (HBV) and the human immunodeficiency virus ...

journal_title：Medical hypotheses

authors： Sallie R

更新日期：2004-01-01 00:00:00

abstract：:Nearly two million people suffer traumatic brain injury in the US each year. These injuries alter adversely the metabolism of myelin, a major lipid material in brain, both in people and in experimental injuries of animals. A newly discovered and severe human neuropathy from copper deficiency provides evidence that som...

journal_title：Medical hypotheses

authors： Klevay LM

更新日期：2013-12-01 00:00:00

abstract：:Host cholesterol is widely getting recognized as an important factor in the pathogenesis of tuberculosis in multiple ways. Therefore it is logically expected that cholesterol reduction by statins is going to have a positive outcome in the context of tuberculosis management. But at the present moment statin therapy in ...

journal_title：Medical hypotheses

authors： Banerjee D,Bhattacharyya R

更新日期：2014-07-01 00:00:00

abstract：:The mitogenic action of the estrogen-receptor complex is supposedly similar in both normal and malignant target tissues. As receptors are present in several types of non-target tissues, in the case of lesions at the nuclear acceptor sites, the complex in those might be able to cause successive mitoses. Estrogen-depend...

journal_title：Medical hypotheses

authors： Litvay M

更新日期：1979-09-01 00:00:00

abstract：:The physical interaction between the red blood cells and colloidal silica leads to hemolysis. We propose that the nature of the red-cell elimination as the result of this interaction is not random. As the negatively charged silica particles at the physiological conditions electrostatically react with the positive site...

journal_title：Medical hypotheses

authors： Gerashchenko BI,Gerashchenko II,Pantazis CG

更新日期：1996-07-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. The hallmark pathologic feature of PD is dopamine deficiency, caused by the degeneration of nigrostriatal dopaminergic neurons. Current treatments for PD mainly address the dopaminergic features of the disease; howe...

journal_title：Medical hypotheses

authors： Tsai SJ

更新日期：2007-01-01 00:00:00

abstract：:The Aquatic Ape Theory claims that human ancestors once lived in a semi-aquatic habitat. Some human diseases might be explained by our aquatic past. Such problems include hyperventilation, periodic breathing, laryngo- and bronchospasm, vasomotor rhinopathy, seborrhea, dandruff, male pattern alopecia, rhinophyma, osteo...

journal_title：Medical hypotheses

authors： Verhaegen MJ

更新日期：1987-11-01 00:00:00

abstract：:The possibility of a pathway, common to progression, in entities in which activated macrophages or microglia are present, amenable to particular therapies, is discussed. Immunoglobulin synthesis and activation of the complement pathway may be critical elements in progression. It is possible progression in a proportion...

journal_title：Medical hypotheses

authors： Milder DG

更新日期：2006-01-01 00:00:00

abstract：:The paper discusses certain dynamic processes leading to meiotic (haploid) partition of chromatids via the chiasmatic mode in mammalian spermatic cells. The achiasmatic case is also reviewed briefly and only in the context of homologs with centromeric braids arrayed in the Para configuration. ...

journal_title：Medical hypotheses

authors： Matioli GT

更新日期：1994-12-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) is a novel technique of non-invasive brain stimulation which has been used to treat several neuropsychiatric disorders such as major depressive disorder, chronic pain and epilepsy. Recent studies have shown that the therapeutic effects of rTMS are associated with pla...

journal_title：Medical hypotheses

authors： Brunoni AR,Boggio PS,Fregni F

更新日期：2008-08-01 00:00:00

abstract：:Roux-en-Y gastric bypass (RYGB) surgery is one of the most effective treatments for obesity and type II diabetes. RYGB was originally believed to work by mechanically restricting caloric intake or causing macronutrient malabsorption. However, such mechanical effects play no role in the remarkable efficacy of gastric b...

journal_title：Medical hypotheses

authors： Celiker H

更新日期：2017-09-01 00:00:00

abstract：:The etiologic basis of urinary tract anomalies and dysfunctional voiding largely remain unknown. However, the travel of urine from renal pelvis into the amniotic cavity under the pressures exerted by amniotic fluid satisfactorily explains the etiologic basis. Amniotic pressure is affected by the changes in maternal in...

journal_title：Medical hypotheses

authors： Tanyel FC

更新日期：2000-01-01 00:00:00

abstract：:For some considerable time, there has been a growing awareness that defective essential fatty acid metabolism plays a causal role in the pathogenesis of both schizophrenia and non-insulin-dependent diabetes mellitus (NIDDM) but the influence of defective essential fatty acid metabolism in the pathogenesis of rheumatoi...

journal_title：Medical hypotheses

authors： Holden RJ

更新日期：1995-08-01 00:00:00

abstract：:Hypertensive left ventricular hypertrophy (LVH) is a maladaptive response to chronic pressure overload and a strong independent risk factor for cardiovascular disease. Regression of LVH is associated with improved prognosis. Regression of LVH with antihypertensive therapy (angiotensin-converting enzyme inhibitors, ang...

journal_title：Medical hypotheses

authors： Quintana-Villamandos B,Delgado-Baeza E

更新日期：2016-02-01 00:00:00

abstract：:Essential hypertension is a heterogeneous multifactorial syndrome associated with a high cardiovascular risk. A multiple choice of antihypertensive drugs is available; however, a high individual variability to the antihypertensive therapy is still responsible for a modest reduction of the CV risk and not satisfactory ...

journal_title：Medical hypotheses

authors： Ferrari P,Ferrandi M,Valentini G,Manunta P,Bianchi G

更新日期：2007-01-01 00:00:00

abstract：:The aim of this study is to identify a possible function of Active Sleep (AS), also known as Rapid Eye Movement Sleep (REM) in humans, as a protective state during early Central Nervous System (CNS) development. Previous research suggest pharmacological agents that inhibit high levels of neuronal activity in the CNS (...

journal_title：Medical hypotheses

authors： Morrissey MJ,Duntley SP,Anch AM,Nonneman R

更新日期：2004-01-01 00:00:00

abstract：:We have previously presented a new Systemic Evolutionary Theory of Cancer (SETOC) based on the failure of proper endosymbiosis in eukaryotic cells. Here, we propose that the progressive uncoupling of two endosymbiotic subsystems (information and energy) inside the cell, as a consequence of long-term injuries, gives ri...

journal_title：Medical hypotheses

authors： Mazzocca A,Ferraro G,Misciagna G,Fais S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Ovarian cancer has a different prognosis between early (I and II) and advanced stage (III and IV). The mechanism of disease progression is unknown, but patients with advanced disease may have a higher propensity for seeding of the abdominal cavity early in the disease process than those with early stage. The...

journal_title：Medical hypotheses

authors： Horvath LE,Werner T,Boucher K,Jones K

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Eelier studies demonstrated the up-regulation of some transcriptional factors such as Oct4, Nanog, Sox2 in undifferentiated cancer cells. These transcriptional regulators are up-regulated in pluripotent cells, as well and are responsible for cell reprogramming in normal cells. It might be said that normal ce...

journal_title：Medical hypotheses

authors： Tavakol S

更新日期：2014-12-01 00:00:00

abstract：:Incidental pituitary adenoma is the common finding during brain imaging. According to multistep model of pituitary tumourigenesis genetic alterations provide the initiating event that transforms cells while hormones play a role in promoting cell proliferation. Development of pituitary adenoma in a case of excessive hy...

journal_title：Medical hypotheses

authors： Kastelan D,Korsic M

更新日期：2007-01-01 00:00:00

abstract：:One of the most commonly alleged contraindications to the use of (ethylene diamine tetraacetic acid) chelation therapy is possible renal damage. In this experiment, 13 subjects with chronic degenerative disorders and with renal damage were treated with infusions that included EDTA, vitamins, mineral and oral supplemen...

journal_title：Medical hypotheses

authors： Sehnert KW,Clague AF,Cheraskin E

更新日期：1984-11-01 00:00:00

abstract：:Micelle is a stable, passively targetable and solubilizing minute particle, and plays a key role to anticancer drug delivery for chemotherapy. With an increasing number of novel polymeric micelles synthesized, many anticancer drugs have been core-encapsulated in the micelles. However, only single drug was studied as t...

journal_title：Medical hypotheses

authors： Liu P,Wang B,Weili Qiao JL

更新日期：2008-09-01 00:00:00

abstract：:The present study developed a feature selection (FS)-based decision support system using the electroencephalography (EEG) signals recorded from neonates with and without seizures. The study employed 10 different FS algorithms to reduce the classification cost by using fewer features and to improve the classification p...

journal_title：Medical hypotheses

authors： Açıkoğlu M,Tuncer SA

更新日期：2020-02-01 00:00:00

abstract：:The non-invasive assessment of chronic tissue hypoxia is difficult. Pulse oximetry only allows the peripheral oxygen saturation to be measured, while the detection of hyperlactataemia needs to take into account the fact that the accumulation of lactic acid may result from several causes other than prolonged tissue hyp...

journal_title：Medical hypotheses

authors： Puri BK,Monro JA

更新日期：2018-03-01 00:00:00

abstract：:Skin cells produce endogenous opioids in response to light. This results in increased skin and plasma levels of endogenous opioids. Increased plasma levels of endogenous opioids may improve mood and affect behavior. The author suggests that improvement in mood after exposure to light may be related to the light-induce...

journal_title：Medical hypotheses

authors： Sher L

更新日期：2001-11-01 00:00:00

abstract：:The mechanisms by which blast pressure waves cause mild-to-moderate traumatic brain injury (mTBI) are an open question. Possibilities include acceleration of the head, direct passage of the blast wave via the cranium, and propagation of the blast wave to the brain via a thoracic mechanism. The hypothesis that the blas...

journal_title：Medical hypotheses

authors： Courtney AC,Courtney MW

更新日期：2009-01-01 00:00:00

abstract：:Long pentraxin 3 (PTX3) is a recently discovered multimeric inflammatory mediator that is structurally linked to short pentraxins, such as C-reactive protein (CRP) and serum amyloid P component. PTX3 is produced by a variety of tissues and cells, including vascular endothelial cells and macrophages. Because of its ext...

journal_title：Medical hypotheses

authors： Parlak A,Iyisoy A,Aydogan U,Cakir E,Saglam K

更新日期：2012-09-01 00:00:00