Abstract：
:Enormous amounts of lactic acid are produced during endurance sport by muscle cells. This metabolite is thought responsible for the muscle pain and the fatigue during sport. Its internal removal from the body by enzymatic conversion depends mainly on the capacity of the hepatic gluconeogenesis that converts lactic acid to glucose. The extraordinary sportive results of the racing cyclist Lance Armstrong did us realize that a high capacity of hepatic gluconeogenesis was the basis of his success, because it might have provided him with less pain complaints caused by lactic acid and with an extra source of energy from lactic acid. This enhanced gluconeogenesis can be due to his heavy training program. At the age of 12-13 years he daily swam 10,000m and cycled 32km. In later years as cyclist his training labour was also more than normal. A constitutional increased gluconeogenesis cannot be excluded, because as a boy of 12 years he became already fourth in 1500m free style swimming in a contest for swimmers from whole Texas. The last argument for an increased gluconeogenesis is that Armstrong in October 1996 suffered from an extensively disseminated testicular tumour. This large tumour load caused that in the tumour the oxidative (=aerobic) energy generation changed into a fermentative (=anaerobic) one. This resulted in a high increase of lactic acid that putted up the gluconeogenesis in the liver. We think that this stimulated, high level gluconeogenesis remained high in the following years, when Armstrong restarted cycling, that it provided him with extra energy from lactic acid and with fewer complaints due to the exercise, and that thus this was the basis of his success.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Bongaerts GP,Wagener DJdoi
10.1016/j.mehy.2006.04.054subject
Has Abstractpub_date
2007-01-01 00:00:00pages
9-11issue
1eissn
0306-9877issn
1532-2777pii
S0306-9877(06)00326-4journal_volume
68pub_type
杂志文章abstract：:In the present study, we used the potential of bioinformatics and computational analysis to predict the existence and biological relevance of zinc finger (ZF) motifs in heamagglutinin (HA) protein of Avian Influenza (AI) virus. Sequence data of Avian Influenza (AI) viruses were retrieved from accessible databases (Gen...
journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
pub_type： 杂志文章,评审
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journal_title：Medical hypotheses
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更新日期：2005-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1983-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2012-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章,评审
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更新日期：2013-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：1979-07-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.10.012
更新日期：2008-01-01 00:00:00
abstract：:The paper discusses certain dynamic processes leading to meiotic (haploid) partition of chromatids via the chiasmatic mode in mammalian spermatic cells. The achiasmatic case is also reviewed briefly and only in the context of homologs with centromeric braids arrayed in the Para configuration. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(94)90013-2
更新日期：1994-12-01 00:00:00
