Abstract:
:Unstable (CAG)n trinucleotide repeat microsatellites are hypothesized to cause schizophrenia. The (CAG)n microsatellite of dominant spinal cerebellar ataxia type 1 (SCA1) is a candidate schizophrenia gene. Autism results from expansions of (CGG)n and (GAA)n trinucleotide repeat stretches at fragile X syndrome (FRAXA), and the recessive Friedreich's ataxia (FA). Dominant ataxia genes may cause schizophrenia and recessive ataxia genes may cause autism. Syndromes with autism show purine synthesis defects (PSDs) and/or pigmentation defects (PDs). Autism is caused by very lengthy expansions of (CAG)n, (CGG)n and (GAA)n repeats, while schizophrenia results from much smaller (CAG)n and (CGG)n repeat expansions.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Fischer KMdoi
10.1016/s0306-9877(98)90080-9subject
Has Abstractpub_date
1998-09-01 00:00:00pages
223-33issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(98)90080-9journal_volume
51pub_type
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
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pub_type: 历史文章,杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.01.010
更新日期:2011-04-01 00:00:00
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更新日期:1993-10-01 00:00:00
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更新日期:2010-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.mehy.2013.04.022
更新日期:2013-08-01 00:00:00
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2000-04-01 00:00:00
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journal_title:Medical hypotheses
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更新日期:2011-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00