Natriuresis of fasting: the possible role of leptin-neuropeptide Y system.

abstract：:Seroepidemiological, clinical and molecular findings suggest that the acquired immune deficiency syndrome virus human immunodeficiency virus-1 was introduced into the human species at the time (late 1950s) and in the geographic area (Zaire) in which millions of Africans were vaccinated with attenuated poliomyelitis vi...

journal_title：Medical hypotheses

authors： Reinhardt V,Roberts A

更新日期：1997-05-01 00:00:00

abstract：:It is estimated that about 1 million patients are hospitalized for acute coronary events each years in the United States. An acceptable theory is that the acute coronary syndrome is caused by rupture of the atherosclerotic plaque with superimposed thrombus, which is a complex process and involving a number of differen...

journal_title：Medical hypotheses

authors： Fang CH,Li JJ,Hui RT

更新日期：2005-01-01 00:00:00

abstract：:Focal epilepsy secondary esp to scar or injured cortical tissue forms a source of constant depolarisation site with or without emitting negative charges (current of injury) into the surrounding area. This focal site is localised by EEG, MRI and if required, by PET and/or SPECT studies. The author postulates to implant...

journal_title：Medical hypotheses

authors： Jaseja H

更新日期：2002-11-01 00:00:00

abstract：:We describe a six-month-old girl with microcephaly, developmental delay, truncal hypotonia, left pyramidal signs, partial seizures and myoclonic spasms, born to a feverish mother. MRI showed bilateral vascular lesions in the territory of the middle cerebral arteries, prevalent in the right hemisphere, together with hy...

journal_title：Medical hypotheses

authors： Spalice A,Del Balzo F,Papetti L,Nicita F,Ursitti F,Salvatori G,Iannetti P

更新日期：2011-08-01 00:00:00

abstract：:Medicine today is an extremely heterogeneous field of knowledge, based on clinical observations and action knowledge and on data from the biological, behavioral and social sciences. We hypothesize at first that medicine suffers from a disciplinary hyper-diversity compared to the level of conceptual interdisciplinary i...

journal_title：Medical hypotheses

authors： Tretter F,Löffler-Stastka H

更新日期：2019-12-01 00:00:00

abstract：:Accurate detection and prevention of overuse musculoskeletal injuries is limited by the nature of somatic tissue injury. In the pathogenesis of overuse injuries, it is well recognized that an abnormal inflammatory response occurs within somatic tissue before pain is perceived which can disrupt the normal remodeling pr...

journal_title：Medical hypotheses

authors： Gisselman AS,Baxter GD,Wright A,Hegedus E,Tumilty S

更新日期：2016-02-01 00:00:00

abstract：UNLABELLED:One plausible explanation for the controversy that surrounds the causes and clinical management of obesity is the notion that overeating and obesity may only be a couple of "symptoms" associated with a yet to be discovered medical disorder. OBJECTIVES:To introduce the Salted Food Addition Hypothesis. This t...

journal_title：Medical hypotheses

authors： Cocores JA,Gold MS

更新日期：2009-12-01 00:00:00

abstract：:The physical interaction between the red blood cells and colloidal silica leads to hemolysis. We propose that the nature of the red-cell elimination as the result of this interaction is not random. As the negatively charged silica particles at the physiological conditions electrostatically react with the positive site...

journal_title：Medical hypotheses

authors： Gerashchenko BI,Gerashchenko II,Pantazis CG

更新日期：1996-07-01 00:00:00

abstract：:The biophysical processes during electroconvulsive therapy (ECT) are discussed. The multilayer head structure causes a shunting and spreading of the major portions of the current all over the extracranial tissues. The final effect is that only a small percentage of the injected current passes into the brain. The secon...

journal_title：Medical hypotheses

authors： Zyss T

更新日期：1994-08-01 00:00:00

abstract：:N-acetylaspartate (NAA) is an intermediary metabolite that is found in relatively high concentrations in the human brain. More specifically, NAA is so concentrated in the neurons that it generates one of the most visible peaks in nuclear magnetic resonance (NMR) spectra, thus allowing NAA to serve as "a neuronal marke...

journal_title：Medical hypotheses

authors： Clark JF,Doepke A,Filosa JA,Wardle RL,Lu A,Meeker TJ,Pyne-Geithman GJ

更新日期：2006-01-01 00:00:00

abstract：:In addition to classical metastatic pathways, recently gastric cancer was described having an alternative route called "endoluminal exfoliation". Provisional analyses demonstrated, in fact, this kind of shedding is associated with several clinico-pathological features indicative of aggressive behavior and resulted to ...

journal_title：Medical hypotheses

authors： Virgilio E,Balducci G,Mercantini P,Giarnieri E,Giovagnoli MR,Montagnini M,Proietti A,D'Urso R,Cavallini M

更新日期：2018-05-01 00:00:00

abstract：:Schizophrenia has a polygenic mode of inheritance and an estimated heritability of over 80%, but success in understanding its genetic underpinnings to date has been modest. Unlike in trinucleotide neurodegenerative disorders, the phenomenon of genetic anticipation observed in schizophrenia or bipolar disorder has not ...

journal_title：Medical hypotheses

authors： Hegde MV,Saraph AA

更新日期：2011-08-01 00:00:00

abstract：:The per review system for the assessment of research proposals is widely respected by working scientists. Nevertheless two problems associated with the operation of this system by the US National Institutes of Health are identified. First the scientist has no control over which committee will review an application and...

journal_title：Medical hypotheses

authors： Rosenberg E

更新日期：1976-01-01 00:00:00

abstract：:The mechanism by which polyglutamine expansions in several proteins lead to neurodegenerative disorders remains largely unknown. The biochemical properties of polyglutamine repeats suggest one possible explanation; endolytic cleavage at a glutaminyl-glutaminyl bond followed by pyroglutamate formation may contribute to...

journal_title：Medical hypotheses

authors： Saido TC

更新日期：2000-03-01 00:00:00

abstract：:Non-invasive molecular analysis of fetal DNA is the diagnostic goal of prenatal medicine. Circulating fetal DNA can be detected in maternal plasma. Recently, it has been detected in the urine of pregnant women. We hypothesize that fetal DNA is present also in maternal saliva and that advances in stabilization and isol...

journal_title：Medical hypotheses

authors： Vlková B,Szemes T,Minárik G,Turna J,Celec P

更新日期：2010-02-01 00:00:00

abstract：:Over the last century and a half there has been a secular decline in the age of menarche in Western, industrialized cultures. This trend has been largely ascribed to improved nutrition and health, and we offer an alternative hypothesis that changes in socio-economic conditions have resulted in changes in the pheromona...

journal_title：Medical hypotheses

authors： Burger J,Gochfeld M

更新日期：1985-05-01 00:00:00

abstract：:Fibromyalgia (FM) is a debilitating, widespread pain disorder that is assumed to originate from inappropriate pain processing in the central nervous system. Psychological and behavioral factors are both believed to underlie the pathogenesis and complicate the treatment. This hypothesis, however, has not yet been suffi...

journal_title：Medical hypotheses

authors： Hulens M,Dankaerts W,Stalmans I,Somers A,Vansant G,Rasschaert R,Bruyninckx F

更新日期：2018-01-01 00:00:00

abstract：:Obesity is a major risk-factor for the development of insulin resistance, type 2 diabetes, and cardiovascular disease. Circulating molecules associated with obesity, such as saturated fatty acids and cholesterol crystals, stimulate the innate immune system to incite a chronic inflammatory state. Studies in mouse model...

journal_title：Medical hypotheses

authors： Demidowich AP,Davis AI,Dedhia N,Yanovski JA

更新日期：2016-07-01 00:00:00

abstract：:In a recent issue of Medical Hypotheses, Dr H L Newbold repeats the assertion that the cause of James B Duke's death in 1925 was pernicious anemia. Dr Newbold postulates that Mr Duke was neurologically impaired as a result of vitamin B-12 deficiency and that he suffered from depression. In an attempt to relieve this d...

journal_title：Medical hypotheses

authors： Halperin EC

更新日期：1991-11-01 00:00:00

abstract：:Most COVID-19 infected individuals present with mild flu-like symptoms; however, 5-10% of cases suffer from life-threatening pneumonia and respiratory failure. The pathogenesis of SARS-CoV-2 and its pathology of associated acute lung injury (ALI), acute respiratory distress syndrome (ARDS), sepsis, coagulopathy and mu...

journal_title：Medical hypotheses

authors： Yaqinuddin A,Kashir J

更新日期：2020-10-01 00:00:00

abstract：:Cholesterol efflux from macrophage foam cells, the initial step of reverse cholesterol transport, is assumed to be the most relevant step with respect to atherosclerosis. As one of the ATP-binding cassette transporter (ABC) family members, ABCG1 plays a critical role in the process of cholesterol efflux. It has been r...

journal_title：Medical hypotheses

authors： Ni ZL,Zhao SP,Wu Z

更新日期：2007-01-01 00:00:00

abstract：:Cardiac chambers have afferent connections to the brainstem and to the spinal cord. Vagal afferents mediate depressor responses and become activated by volume expansion, increased myocardial contractility and atrial natriuretic factor. Sympathetic afferents, on the contrary, are activated by metabolic mediators, myoca...

journal_title：Medical hypotheses

authors： Davila DF,Donis JH,Bellabarba G,Torres A,Casado J,Mazzei de Davila C

更新日期：2000-02-01 00:00:00

abstract：:Many embryonic genes may be sets of repeated genes. Processes of differentiation where the quantity of gene activity changes during embryogenesis may not reflect the transcription rate per se but instead be a result of the state of expression of constitutive repeated genes. Such repeated genes (in fact or theory) is d...

journal_title：Medical hypotheses

authors： Hancock RL

更新日期：1991-03-01 00:00:00

abstract：:It is hypothesized that Alzheimer's disease is a human phylogenetic disease which has a common multifactorial pathogenesis in sporadic and familial cases and in Down syndrome, related to a genomic character function G(x). Increments in G(x) accompanied the increased gene expression that sustained brain growth and diff...

journal_title：Medical hypotheses

authors： Rapoport SI

更新日期：1989-07-01 00:00:00

abstract：:No survival profit has been achieved for patients with disseminated prostate cancer since hormonal therapy was introduced. It is proposed that dissemination of rare prostatic cancer stem cells may lead to metastatic disease and that resistance of these cells to androgen ablation makes them responsible for failure of c...

journal_title：Medical hypotheses

authors： Drewa T,Styczynski J

更新日期：2008-11-01 00:00:00

abstract：:Behcet's disease (BD) is a chronic, multisystem inflammatory disorder characterized by relapsing oral aphthous and genital ulcers, ocular inflammation, erythemanodosum and folliculitis-like lesions of the skin, arthritis, and central nervous system involvement. Its pathogenesis has not been fully elucidated but the et...

journal_title：Medical hypotheses

authors： Qin H,Cai J,Xu H,Gong Y

更新日期：2009-07-01 00:00:00

abstract：:Diabetes is a metabolic condition associated with hyperglycemia manifested by the elevation of blood glucose levels occurring when the pancreas decreases or stops the production of insulin, in case of insulin resistance or both. The current literature supports that insulin resistance may be responsible for the memory ...

journal_title：Medical hypotheses

authors： Leão LL,Tangen G,Barca ML,Engedal K,Santos SHS,Machado FSM,de Paula AMB,Monteiro-Junior RS

更新日期：2020-06-01 00:00:00

abstract：:Preliminary reports have suggested that chronic, intermittent electrical stimulation of the cervical vagus nerve (VNS) is an effective treatment for patients who suffered from medically refractory epilepsy. But the traditional VNS is an invasive and implantable procedure that will bring some injury to the patient. Ana...

journal_title：Medical hypotheses

authors： Yang AC,Zhang JG,Rong PJ,Liu HG,Chen N,Zhu B

更新日期：2011-08-01 00:00:00

abstract：:Dupuytren's disease is a pathological condition of the palmar fascia characterized by the formation of contractile disease cords that result in permanent finger contracture. This condition is believed to progress from a myofibroblast-rich nodule in the early clinical stages of the disease to a contractile disease cord...

journal_title：Medical hypotheses

authors： Vi L,Gan BS,O'Gorman DB

更新日期：2010-03-01 00:00:00

abstract：:Treatment-resistant schizophrenia (TRS) is one of the subgroups of schizophrenia of which little is known with regard to its optimal mechanism. Treatment response, either as full remission of symptoms or prediction by biomarker, is important in psychiatry. We have proposed a model that integrates dopaminergic and glut...

journal_title：Medical hypotheses

authors： Huang LC,Lin SH,Tseng HH,Chen KC,Yang YK

更新日期：2020-10-01 00:00:00