Gout attacks and lunar cycle.

abstract：:Spontaneous acute occlusion of the coronary artery produces regional myocardial ischemia and infarction. This coronary occlusion could be due to rapid progression of atherosclerosis or vasospasm. The factors that can precipitate an acute attack of myocardial infarction or coronary spasm are not known. It is proposed t...

journal_title：Medical hypotheses

authors： Das UN

更新日期：1992-09-01 00:00:00

abstract：:Transient period represents the time window between the exposure and response to the given stimuli inflicting the stress on the host. However, this time window is unlikely to engage in variety of signaling to culminate drastic impact on the host cell rather it is evolutionary in its sense implying a slow process. But ...

journal_title：Medical hypotheses

authors： Kannan S

更新日期：2004-01-01 00:00:00

abstract：:The few existing hypotheses for the function of the human hymen are weak. These are briefly reviewed, and a new hypothesis is proposed. We suggest that the appearance of the juvenile human hymen is based on 'premature' birth, following which infant helplessness and a subsequent advantage for vaginal protection from ex...

journal_title：Medical hypotheses

authors： Hobday AJ,Haury L,Dayton PK

更新日期：1997-08-01 00:00:00

abstract：:Sudden cardiac death prematurely claims the lives of some 7 million each year worldwide. It occurs primarily in patients with an underlying structural cardiac abnormality, and regardless of the type of the underlying pathology (heart failure, dilated and hypertrophic cardiomyopathies, myocardial infarction and aging),...

journal_title：Medical hypotheses

authors： Sovari AA,Morita N,Weiss JN,Karagueuzian HS

更新日期：2008-08-01 00:00:00

abstract：:A primary goal in antimicrobial drug design is to find molecules which inhibit key proteins in bacteria without affecting mammalian homologues. To this aim, structural differences between eukaryotic and prokaryotic enzyme proteins involved in life processes are widely exploited. The membrane-bound enzyme complex ATP s...

journal_title：Medical hypotheses

authors： Nesci S,Ventrella V,Trombetti F,Pirini M,Pagliarani A

更新日期：2014-08-01 00:00:00

abstract：:For a virus to survive and replicate in an organism, it must employ strategies to evade and misdirect the host's immune response. There is compelling evidence that the primary immunoevasive strategy utilized by the SARS virus, like influenza, is to inhibit its host's corticosteroid stress response. This is accomplishe...

journal_title：Medical hypotheses

authors： Wheatland R

更新日期：2004-01-01 00:00:00

abstract：:A search for control mechanisms involving embryonic genes is explored reviewing a variety of subject areas including, a) the methylation status of DNA and the globin gene, b) ethionine and steroid effects on expression of embryonic genes, c) alpha-fetoprotein gene activity induced by carcinogens and in hepatomas. Also...

journal_title：Medical hypotheses

authors： Hancock RL

更新日期：1993-05-01 00:00:00

abstract：:Although the role of the lymphatic circulation in the uptake of dietary fat is well established, the absorption of water-soluble compounds, secreted by the enterocyte into the lymph, has received little attention. In the present study an estimate is made of the amount of dietary glucose that can be absorbed via the ly...

journal_title：Medical hypotheses

authors： Argilés JM,Fernández-López JA,Casado J,Alemany M

更新日期：1990-11-01 00:00:00

abstract：:We have previously presented a new Systemic Evolutionary Theory of Cancer (SETOC) based on the failure of proper endosymbiosis in eukaryotic cells. Here, we propose that the progressive uncoupling of two endosymbiotic subsystems (information and energy) inside the cell, as a consequence of long-term injuries, gives ri...

journal_title：Medical hypotheses

authors： Mazzocca A,Ferraro G,Misciagna G,Fais S

更新日期：2018-12-01 00:00:00

abstract：:Damaged DNA can lead to aneuploidy and/or chromosomal instability, which is believed to be major contributor to tumor progression. Genotoxic and oncogenic stresses-induced DNA damage activate the tumor suppressor pathways initiate DNA damage response (DDR). One of the cellular fates in response to DDR is permanent gro...

journal_title：Medical hypotheses

authors： Erol A

更新日期：2010-06-01 00:00:00

abstract：:Sickle cell anaemia confirms that minor mutations in protein sequence can have catastrophic effects. However, RNA transcription depends on polymerases that have low fidelity and introduce errors at a rate of 10(-5) substitutions/base synthesised. For many large proteins translation of these errors could result in sign...

journal_title：Medical hypotheses

authors： Sallie R

更新日期：2004-01-01 00:00:00

abstract：:This paper presents the hypothesis, that pain and functional disturbances of organs which lie on the midline of the body might be caused by a venous congestion of these organs. Cause of their congestion is the participation of these organs (vertebral column, skull, brain, spinal medullary, uterus, prostate, left ovary...

journal_title：Medical hypotheses

authors： Scholbach T

更新日期：2007-01-01 00:00:00

abstract：:September 17th, 2009 marks the 15th anniversary of Sir Karl Popper's death. Popper was an outspoken champion of critical rationalism, and a constant critic of authoritarian tendencies in science and society. He was also one of the spiritual founders of this journal and served on its first editorial advisory board. Pop...

journal_title：Medical hypotheses

authors： Notturno MA

更新日期：2009-12-01 00:00:00

abstract：:Many studies have focused on the detrimental effects of malnourishment to the performance of the brain and peripheral nerves. Undernourished children and adults have been studied extensively to establish these consequences. Little attention has been given to the body habitus that affects optimum neurological performan...

journal_title：Medical hypotheses

authors： Grantham J,Henneberg M

更新日期：2014-11-01 00:00:00

abstract：:Information about the etiology of pressure sores has been contradictory and is inconsistent with the idea that pressure sore formation is due extensively to depriving a tissue region of blood. Based on these observations and on studies done in the cooperating laboratories, an hypothesis has been formulated that integr...

journal_title：Medical hypotheses

authors： Krouskop TA

更新日期：1983-06-01 00:00:00

abstract：:Fissured tongue (FT) is a condition frequently seen in the general population. Clinically, FT is characterized by grooves that vary in depth and are noted along the dorsal and/or dorsolateral aspects of the tongue. Furthermore, FT presents many enlarged, smooth filiform papillae and subepithelial inflammatory infiltra...

journal_title：Medical hypotheses

authors： Järvinen J,Mikkonen JJ,Kullaa AM

更新日期：2014-06-01 00:00:00

abstract：:The artificial pancreas requires fast and reliable glucose measurements. The peritoneal space has shown promising results, and in one of our studies we detected glucose changes in the peritoneal space already at the same time as in the femoral artery. The peritoneal lining is highly vascularised, covered by a single l...

journal_title：Medical hypotheses

authors： Åm MK,Fougner AL,Ellingsen R,Hjelme DR,Bösch PC,Stavdahl Ø,Carlsen SM,Christiansen SC

更新日期：2019-11-01 00:00:00

abstract：:At the end of 2019, a new kind of pneumonia which was proven to be supported by novel coronaviruses named SARS-CoV-2 emerges and it seems to be more complicate in its clinical course and management. Related researches have demonstrated that SARS-CoV-2 serves roles in respiratory, intestinal and neuronal diseases. Give...

journal_title：Medical hypotheses

authors： Tao H,Ge G,Li W,Liang X,Wang H,Li N,Sun H,Zhang W,Geng D

更新日期：2020-12-01 00:00:00

abstract：:In a previous paper, I have proposed that the deficiency of an endogenous caffeine-like substance is the underlying pathogenic mechanism in schizophrenia (1). In the present paper, my new concept is used to explain many of the clinical, biochemical, radiologic and pharmacologic facts about schizophrenia. ...

journal_title：Medical hypotheses

authors： Missak SS

更新日期：1991-10-01 00:00:00

abstract：:Infantile neuroaxonal dystrophy (INAD) and Duchenne muscular dystrophy (DMD) are two deadly neuromuscular degenerative diseases of childhood. Knowledge on their pathophysiological mechanisms may direct us towards treatment or a cure. Although these diseases are caused by two totally different gene-mutations and cause ...

journal_title：Medical hypotheses

authors： Offringa-Hup A

更新日期：2020-04-01 00:00:00

abstract：:In the last decades, relevant efforts have been made to reduce the cancer incidence in the European Union. The prevention programmes against cancer have obtained satisfactory results except for colorectal cancer (CRC). Identification of risk factors is primordial to plan preventive strategies for CRC. We hypothesize t...

journal_title：Medical hypotheses

authors： Manerio E,Rodas VL,Costas E,Hernandez JM

更新日期：2008-01-01 00:00:00

abstract：:Fibromyalgia syndrome (FMS) is a chronic widespread pain syndrome that is estimated to affect 4-8 million US adults. The exact molecular mechanisms underlying this illness remain unclear, rendering most clinical treatment and management techniques relatively ineffective. It is now known that abnormalities in both noci...

journal_title：Medical hypotheses

authors： Recla JM,Sarantopoulos CD

更新日期：2009-08-01 00:00:00

abstract：:Genome imprinting has an essential role in normal embryonal mammalian development. Starting early in differentiation, the transcripts of certain human genes, e.g. the paternally-H19 and the maternally-imprinted IGF2, are expressed in specific tissues and organs during fetal life. In several malignant disorders, imprin...

journal_title：Medical hypotheses

authors： Biran H,Ariel I,De Groot N,Hochberg A

更新日期：1994-08-01 00:00:00

abstract：:Can consciousness be understood as the ongoing active creation of information (of meaning)? 'Emergence', the central concept in this hypothesis, plays an essentially different role in it than in theories previously proposed. ...

journal_title：Medical hypotheses

authors： Atkin A

更新日期：1992-08-01 00:00:00

abstract：:Regulation of ion transport across the airway mucosa may be involved in the mechanisms producing hyperreactivity and asthma. Atrial Natriuretic Peptide (ANP) has been proposed to participate in the pathogenesis of asthma, and it has been found to have a bronchodilatory effect on asthmatic patients. Experimental eviden...

journal_title：Medical hypotheses

authors： Almirall JJ,Hedenstierna G

更新日期：1991-09-01 00:00:00

abstract：:The author, in an attempt to clarify whether the rise of alternative medicine is a phenomenon characteristic of our time or whether it existed in the past as well, has identified at least three alternative medicines, which developed in ancient Rome, ancient India and in the medieval Islamic world. The circumstances le...

journal_title：Medical hypotheses

authors： Prioreschi P

更新日期：2000-10-01 00:00:00

abstract：:"Consciousness" "mood," "identity" and "personality" are all emergent properties from whole-brain organizations; these are typically disturbed in psychiatric disorders. This work proposes that the underlying etiopathology of mental disorders originates from disturbances to global brain dynamics, or "Globalopathies" th...

journal_title：Medical hypotheses

authors： Peled A

更新日期：2013-12-01 00:00:00

abstract：:There are many published studies about the epigenetic effects of the prenatal and infant periods on health outcomes. However, there is very little knowledge regarding the effects of the intrapartum period (labor and birth) on health and epigenetic remodeling. Although the intrapartum period is relatively short compare...

journal_title：Medical hypotheses

authors： Dahlen HG,Kennedy HP,Anderson CM,Bell AF,Clark A,Foureur M,Ohm JE,Shearman AM,Taylor JY,Wright ML,Downe S

更新日期：2013-05-01 00:00:00

abstract：:The presence of the tumour induces important metabolic changes in the cancer patient which are not merely due to the fact that the tumour acts as a parasite, thus depleting the host of nutrients, but that are mainly the result of both tumoral and humoral mediators. The new metabolic status of the cancer patient may le...

journal_title：Medical hypotheses

authors： Argilés JM,López-Soriano FJ

更新日期：1998-11-01 00:00:00

abstract：:The first conjugate vaccine was approved for use in the US in 1988 to protect infants and young children against the capsular bacteria Haemophilus influenzae type b (Hib). Since its introduction in the US, this vaccine has been approved in most developed countries, including Denmark and Israel where the vaccine was ad...

journal_title：Medical hypotheses

authors： Richmand BJ

更新日期：2011-12-01 00:00:00