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Molecular basis of the evolution of drug resistance: potential role of the transient state during infection/drug treatment.

Abstract：

:Transient period represents the time window between the exposure and response to the given stimuli inflicting the stress on the host. However, this time window is unlikely to engage in variety of signaling to culminate drastic impact on the host cell rather it is evolutionary in its sense implying a slow process. But it is reasonable to speculate that most significant signals are initiated at this time, and first responder will confer required adaptive features on the host cells. This alteration would be followed by amplification of appropriate adaptative signals in the successive generation(s), thus conferring the increased adaptability to given stress.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Kannan S

doi

10.1016/j.mehy.2003.04.001

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

71-2

issue

1

eissn

0306-9877

issn

1532-2777

pii

S0306987704001148

journal_volume

63

pub_type

杂志文章

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