Abstract：
:The artificial pancreas requires fast and reliable glucose measurements. The peritoneal space has shown promising results, and in one of our studies we detected glucose changes in the peritoneal space already at the same time as in the femoral artery. The peritoneal lining is highly vascularised, covered by a single layer of mesothelial cells and therefore easily accessible for proper sensor technology, e.g. optical technology. We hypothesize that the rapid intraperitoneal glucose dynamics observed in our study was possible because the sensors were located directly at the peritoneal lining, at the point where the glucose molecules entered the peritoneal space. Glucose travels slowly in fluids by diffusion, and a longer distance between the sensor and the peritoneal lining would consequently result in slower dynamics. We therefore propose to place the glucose sensor in an artificial pancreas as closely to the peritoneal lining as possible, or even utilize appropriate sensor technology to measure glucose in the peritoneal lining itself.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Åm MK,Fougner AL,Ellingsen R,Hjelme DR,Bösch PC,Stavdahl Ø,Carlsen SM,Christiansen SCdoi
10.1016/j.mehy.2019.109318subject
Has Abstractpub_date
2019-11-01 00:00:00pages
109318eissn
0306-9877issn
1532-2777pii
S0306-9877(18)31227-1journal_volume
132pub_type
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