Abstract：
:September 17th, 2009 marks the 15th anniversary of Sir Karl Popper's death. Popper was an outspoken champion of critical rationalism, and a constant critic of authoritarian tendencies in science and society. He was also one of the spiritual founders of this journal and served on its first editorial advisory board. Popper was recognized around the world as one of the 20th century's greatest philosophers of science and one of its most articulate and influential critics of Marxism and closed society. When he died, the contemporary wisdom among professional philosophers was that his philosophy was generally right-but somehow obsolete. Some commentators said that it was now obvious that scientific theories cannot be shown to be true. Others said that we had witnessed the end of history and that his critique of closed societies, while no doubt important in its day, had been fully assimilated into Western thinking and still had meaning, if at all, only for the democracies in transition that were trying to emerge from the former Soviet Union. But 15 years after his death, a look at science and society around the world gives us good reason to remember his philosophy.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Notturno MAdoi
10.1016/j.mehy.2009.09.021subject
Has Abstractpub_date
2009-12-01 00:00:00pages
871-4issue
6eissn
0306-9877issn
1532-2777pii
S0306-9877(09)00626-4journal_volume
73pub_type
传,社论,历史文章abstract：:Traumatic iris sphincter tear has been thought to occur secondary to anteroposterior compression of the globe with defined forces lead to equatorial expansion and active pull along the corneoscleral junction and sphincter tear. However, here in this report, we elaborate the additional forces involved in the traumatic ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.11.013
更新日期：2019-01-01 00:00:00
abstract：:Insufficient attention has been given to reports in the literature describing patients with symptomatic migraine who, in addition to, or instead of, the well-recognized zones of hypofusion, have zones of hyperperfusion, which can be interpreted as hypermetabolism due to neuronal activation. A new neural theory of migr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2000.1214
更新日期：2001-03-01 00:00:00
abstract：:Crossed cerebellar diaschisis (CCD) refers to transneuronal degeneration of the corticopontocerebellar pathway, resulting in atrophy of cerebellum contralateral to supratentorial pathology. CCD is traditionally diagnosed on nuclear medicine studies. Our aim is to apply a biexponential diffusion model, composed of intr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.08.025
更新日期：2018-11-01 00:00:00
abstract：:Hypotheses generally conform to paradigms which, over time, change, usually tardily, after they have become increasingly difficult to sustain under the impact of non-conforming evidence and alternative hypotheses, but more important, when they no longer are comfortably ensconced in the surrounding social-economic-poli...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.07.030
更新日期：2006-01-01 00:00:00
abstract：:Severe affective and behavioral dysregulation, labeled as severe mood dysregulation (SMD), is a widely spread phenomenon among adolescent psychiatric patients. This phenotype constitutes severe impairment across multiple settings, including various symptoms, such as non-episodic anger, mood instability, and hyperarous...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.07.019
更新日期：2011-10-01 00:00:00
abstract：:Invasive carcinoma originates from the epithelial cells lining the lumen of an organ. It is often preceded by metaplasia, dysplasia or carcinoma in situ. The purpose of this review is to suggest that this disease of the epithelium may be, in part, the result of underlying tissue-based disorganization. Human cancer is ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1539
更新日期：2002-04-01 00:00:00
abstract：:Duchenne muscular dystrophy (DMD) is a lethal muscle wasting disease caused by a lack of dystrophin, which eventually leads to apoptosis of muscle cells and impaired muscle contractility. Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated protein 9 (CRISPR/Cas9) gene editing of induced pluripo...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.11.009
更新日期：2018-01-01 00:00:00
abstract：:In a previous paper we predicted that health effects of dietary fats in humans would require half a century or more to be understood, instead of the decade or so predicted during 1956 by an Editorial in The Lancet. It would seem that our prediction may have been optimistic since it has now been reported that trans uns...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(92)90194-h
更新日期：1992-04-01 00:00:00
abstract：:At the end of 2019, a new kind of pneumonia which was proven to be supported by novel coronaviruses named SARS-CoV-2 emerges and it seems to be more complicate in its clinical course and management. Related researches have demonstrated that SARS-CoV-2 serves roles in respiratory, intestinal and neuronal diseases. Give...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110332
更新日期：2020-12-01 00:00:00
abstract：:The etiology of intra-abdominal adhesions is explained by hydrolysis of the peritoneal phospholipid layer caused by phospholipase A2 activity. This view could unify the pre-existing hypotheses that intra-abdominal adhesions are due to ischemia or increased plasminogen activator activity. New therapeutic approaches are...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(93)90109-4
更新日期：1993-12-01 00:00:00
abstract：:Is sleep especially beneficial in times of illness? Despite the widespread use of hypnotics, the medical position on this question is equivocal, for hospital practices seem rarely designed to encourage maximum sleeping. Sleep promotion is defined as the arrangement of conditions so that patients can achieve as much sl...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(84)90005-7
更新日期：1984-09-01 00:00:00
abstract：:An unconventional interaction between a patient and parasites was recently reported, in which parasitic cells invaded host's tissues, establishing several tumors. This finding raises various intriguing hypotheses on unpredicted forms of interplay between a patient and infecting parasites. Here we present four unusual ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.06.012
更新日期：2016-09-01 00:00:00
abstract：:Alpha-fetoprotein (AFP) is overexpressed in the majority of hepatocellular carcinomas (HCCs), and thus may offer attractive target for immunotherapy against this neoplasm. CD40 ligand (CD40L) is the major signal that induces B cells to efficiently present antigen to T cells, and CD40-activated B (CD40-B) lymphocyte ce...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.12.050
更新日期：2009-11-01 00:00:00
abstract：:Einstein is often quoted to have said that without the bee, mankind would have but 4years to live. It is highly unlikely that he made this comment, which was even mentioned in a Lancet article on honey bees. However, the current vanishing of the bees can have serious consequences for human health, because 35% of the h...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.04.003
更新日期：2010-10-01 00:00:00
abstract：:The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 virus is now considered a global public health threat. The primary focus has been on reducing the viral spread and treating respiratory symptoms; as time goes on, the impact of COVID-19 on neurological and haemostatic systems becomes mor...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110480
更新日期：2021-01-04 00:00:00
abstract：:Mood expressions encompassing positive scales like "activity, elation, contemplation, calmness" and negative scales like "anger, excitement, depression, fatigue" were applied for introducing a new tool to assess the effects of acupuncture on brain structures. Traditional acupuncture points defined in the literature fo...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.05.013
更新日期：2015-09-01 00:00:00
abstract：:For some considerable time, there has been a growing awareness that defective essential fatty acid metabolism plays a causal role in the pathogenesis of both schizophrenia and non-insulin-dependent diabetes mellitus (NIDDM) but the influence of defective essential fatty acid metabolism in the pathogenesis of rheumatoi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(95)90066-7
更新日期：1995-08-01 00:00:00
abstract：:Cannabinoid hyperemesis syndrome (CHS), a variant of cyclic vomiting syndrome, is an enigmatic and challenging clinical disorder. As cannabis legalization, use, and potency has increased worldwide over the past decade, so has the prevalence of CHS. These patients often require acute care and inpatient treatment for re...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.04.018
更新日期：2017-06-01 00:00:00
abstract：:Cholesterol efflux from macrophage foam cells, the initial step of reverse cholesterol transport, is assumed to be the most relevant step with respect to atherosclerosis. As one of the ATP-binding cassette transporter (ABC) family members, ABCG1 plays a critical role in the process of cholesterol efflux. It has been r...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.06.042
更新日期：2007-01-01 00:00:00
abstract：:This paper will show that the fractional difference in the human gender ratio (GR) between the GR(at death) for those born in solar cycle peak years (maxima) and the GR(at death) in those born in solar cycle non-peak years (minima), e.g., 0.023, divided by Pi, yields a reasonable approximation of the quantum mechanica...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.03.028
更新日期：2009-09-01 00:00:00
abstract：:Contributory risk factors to premature coronary artery disease (CAD) in premenopausal women are poorly understood and data on this subset of women is lacking. There is growing evidence that the process of inflammation is a part of the atherosclerotic process. Mechanistic insights from animal work suggest that the prof...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.09.010
更新日期：2017-11-01 00:00:00
abstract：:Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic disease in adults, and it is thought to be increasing in incidence. FSGS is often difficult to treat and even has a high propensity to relapse after transplant. Indeed, this suggests that there might be some circulating factor responsible for pro...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1438
更新日期：2001-12-01 00:00:00
abstract：:Immunotherapy has attracted attention as a novel treatment modality for malignant melanoma. Although the use of immunotherapy in metastatic melanoma has shown promising results, there remains a lack of predictive biomarkers indicating treatment benefit from immunotherapy. There is growing evidence suggesting that micr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.05.023
更新日期：2016-08-01 00:00:00
abstract：:The objective of this work is to propose a biomechanical model of sacro-iliac joint dysfunction as a cause of low back pain. Sacro-iliac joint is known to be a source of low back pain. We also know that it is a very stable joint with little mobility. Surrounding lower limb and back muscles contribute a major part of t...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.02.035
更新日期：2005-01-01 00:00:00
abstract：:Nitrosamines have been identified in vaginal secretions of women with trichomoniasis. Both nitrites and amines the elements for nitrosamine synthesis are produced by the abnormal-predominantly anaerobic-vaginal flora of patients with bacterial vaginosis/trichomoniasis. The final formation of nitrosamines could also de...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(84)90159-2
更新日期：1984-12-01 00:00:00
abstract：:Increased level of oxalates in urine and plasma can be attributed to endogenous overproduction, increased ingestion or excessive intestinal absorption. When a supersaturation status is reached, oxalates combine with calcium and crystallize to form 80% of the urinary stones. Several cardiovascular diseases such as coro...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109570
更新日期：2020-04-01 00:00:00
abstract：:P53 is an oncosuppressor protein which acts via transcriptional and non-transcriptional mechanisms. The transcriptional function of p53 is mediated by specific responsive elements (RE). In the present study we found one perfect p53 RE located in the first intron of the gene encoding for CD58 (lymphocyte function Antig...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1476
更新日期：2002-02-01 00:00:00
abstract：:Oxygen therapy, usually administered by a facemask or nasal cannulae, is the current default treatment of respiratory failure. Since respiration entails intake of oxygen and release of carbon dioxide from tissues as waste product, the notion of administering carbon dioxide in respiratory failure appears counter-intuit...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.11.010
更新日期：2018-01-01 00:00:00
abstract：:It is increasingly admitted that Crohn's disease and ulcerative colitis, the two entities of inflammatory bowel disease, are initiated and reactivated by environmental factors in genetically susceptible hosts, and result from aberrant immune response to specific intestinal microbes, in the context of altered compositi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.03.009
更新日期：2018-06-01 00:00:00
abstract：:The resonator theory claims that light scattering by the melanin granules of the retinal pigment epithelium causes light to be reflected back through the outer segment of the cones, in a direction opposite that of the incident light. These two opposite directed wave motions may produce standing waves inside the cone o...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(92)90046-f
更新日期：1992-02-01 00:00:00
