Abstract：
:High blood pressure is an important component of pre-eclampsia. The underlying mechanism of development of hypertension in pre-eclampsia is complicated and still remains obscure. Several theories have been advanced including endothelial dysfunction, uteroplacental insufficiency leading to generalized vasoconstriction, increased cardiac output, and sympathetic hyperactivity. Increased blood flow and pressure are thought to lead to capillary dilatation, which damages end-organ sites, leading to hypertension, proteinuria and edema. Additional theories have been put forward based on epidemiological research, implicating immunological and genetic factors. None of these theories have been substantiated. Based on a review of literature this paper postulates that the initiating event for the development of pre-eclampsia is intermittent hypoxia associated with irregular breathing during sleep, hypoapnea, apnea, inadequate respiratory excursions during the waking hours and inadequate cardiopulmonary synchronization (abnormal sympatho-vagal balance).
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Jerath R,Barnes VA,Fadel HEdoi
10.1016/j.mehy.2009.03.007subject
Has Abstractpub_date
2009-08-01 00:00:00pages
163-6issue
2eissn
0306-9877issn
1532-2777pii
S0306-9877(09)00189-3journal_volume
73pub_type
杂志文章abstract：:Synthetic ligands of the retinoid X receptor (RXR) have shown antidiabetic activity in mice, apparently owing to the fact that they stimulate the transcriptional activity of PPAR-gamma/RXR heterodimers, much like thiazolidinedione drugs. The chlorophyll metabolite phytanic acid has been shown to be a natural ligand fo...
journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章,评审
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：1977-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1995-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(93)90214-b
更新日期：1993-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2019-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：1988-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(95)90116-7
更新日期：1995-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00221-9
更新日期：2002-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.05.002
更新日期：2018-07-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.04.003
更新日期：2007-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(93)90080-a
更新日期：1993-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
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更新日期：2013-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：1994-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1987-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：1991-03-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
