Combination drug therapy for multimodal treatment of cancer by targeting mitochondrial transcriptional pathway: An in-silico approach.

abstract：:In this study, after having formed the hypothesis of the existence of a "Compensating Center" (cerebral?) that orders the increase in the function of one kidney in case of deterioration of its congener, we propose two mechanisms that may lead to the activation of this Center. The first may be the difference between th...

journal_title：Medical hypotheses

authors： Collard M

更新日期：1988-03-01 00:00:00

abstract：:Noonan syndrome (NS OMIM 163950) is a relatively common autosomal dominant developmental disorder characterized by short stature, specific facial features, and congenital cardiac anomalies. Approximately 50-66% of cases have defined mutations in the K-ras/Raf/MEK/ERK pathway that lead to constitutive signaling, but a ...

journal_title：Medical hypotheses

authors： Huang X,Fu Y,Charbeneau RA,Neubig RR

更新日期：2009-07-01 00:00:00

abstract：:The mechanism by which polyglutamine expansions in several proteins lead to neurodegenerative disorders remains largely unknown. The biochemical properties of polyglutamine repeats suggest one possible explanation; endolytic cleavage at a glutaminyl-glutaminyl bond followed by pyroglutamate formation may contribute to...

journal_title：Medical hypotheses

authors： Saido TC

更新日期：2000-03-01 00:00:00

abstract：:The U.S. Environmental Protection Agency's (EPA) proposed drinking water standard for radium-226 (226Ra) of 5 pCi/l is evaluated according to its health basis and carcinogenic implications. Proposed health risks of 226Ra in drinking water by other leading theoreticians (Evans, Gofman-Tamplin and Peterson) are also con...

journal_title：Medical hypotheses

authors： Riddiough CR,Musselman R,Calabrese EJ

更新日期：1977-09-01 00:00:00

abstract：:Space adaptation syndrome (SAS) incapacitates about 50% of the astronauts with symptoms of headache, malaise, vomiting, vertigo, etc. A hypothesis that SAS is caused by elevated intracranial pressure secondary to the cephalad fluid shift in zero G is proposed. A mechanism of how the cephalad fluid shift could cause el...

journal_title：Medical hypotheses

authors： Jennings T

更新日期：1990-08-01 00:00:00

abstract：:Epidural haematoma in newborn infants is rare, and few specific obstetrical data related to its formation are available in the literature. The aim of this study is to discuss the pathophysiology of this condition. EDH is always a post traumatic lesion and it is only possible if the insult has produced a cleavage of th...

journal_title：Medical hypotheses

authors： Hamlat A,Heckly A,Adn M,Poulain P

更新日期：2006-01-01 00:00:00

abstract：:Acute disseminated encephalomyelitis (ADEM) is defined as a multifocal, monophasic, demyelinating, and inflammatory disease involving the central nervous system. It typically begins within 6 weeks of an antigenic challenge such as infection or immunization. Perivenous inflammation, edema and demyelination are the path...

journal_title：Medical hypotheses

authors： Sabayan B,Zolghadrasli A

更新日期：2007-01-01 00:00:00

abstract：:On the basis of the physical properties of magnetic fluids a new technique of whole-body hyperthermia is proposed. Subdomain dextran stabilized magnetite particles injected into the blood-stream can be efficiently heated using an external high-frequency magnetic field, which allows rapid and controllable delivery of h...

journal_title：Medical hypotheses

authors： Babincová M,Sourivong P,Leszczynska D,Babinec P

更新日期：2000-12-01 00:00:00

abstract：:Multiple sclerosis (MS) is a neurodegenerative disease of uncertain etiology. In MS, neurodegeneration is thought to be secondary to autoimmune-mediated damage. However, no cohesive explanation yet exists as to how environmental factors interact to induce a neurodegenerative autoimmune response. Insufficient sunlight ...

journal_title：Medical hypotheses

authors： Hayes CE,Donald Acheson E

更新日期：2008-01-01 00:00:00

abstract：:It is well documented that depressed patients, as a result of their illness, often experience some difficulties with their memory. This hypothesis suggests a vice-versa; that it is a gradual impairment and ultimate failure of specific memory systems that may underpin the onset and continuation of a depressive illness....

journal_title：Medical hypotheses

authors： Frais AT

更新日期：2007-01-01 00:00:00

abstract：:A major factor relating to the oversight of neurological dysfunction and seizures caused by magnesium (Mg++) depletion, involves the buffer functions of the skeletal system orchestrated primarily by the parathyroid. A Mg++ depleted subject may appear relatively asymptomatic until a short period after homeostatic respo...

journal_title：Medical hypotheses

authors： Langley WF,Mann DJ

更新日期：1991-01-01 00:00:00

abstract：:The 2013 American Heart Association Blood Cholesterol Guidelines increased the number of patients recommended for statin therapy in the United States to 56million. Two common statin side effects are muscle pain, referred to as "statin-associated muscle symptoms", and increased risk for new onset type-2-diabetes mellit...

journal_title：Medical hypotheses

authors： Carris NW,Tipparaju SM,Magness DJ,Chapalamadugu KC,Magness RR

更新日期：2017-09-01 00:00:00

abstract：:The concept of local pathology has long served neurology admirably. Relevant models include self-organizing nonlinear brain dynamics, global workspace and dynamic core theories. However such models are inconsistent with certain clinical phenomena found in Charles Bonnet syndrome, disjunctive agnosia and schizophrenia,...

journal_title：Medical hypotheses

authors： Globus GG,O'Carroll CP

更新日期：2010-11-01 00:00:00

abstract：:Juvenile nasopharyngeal angiofibroma (JNA) is the most common benign tumor of the nasopharynx. For reasons unknown, this tumor is found almost always in male population. However, site of origin of JNA is still an enigma. Previously, JNA was considered to arise from the superior aspect of sphenopalatine foramen. Over l...

journal_title：Medical hypotheses

authors： Kairo AK,Kumar R,Sharma SC

更新日期：2020-11-01 00:00:00

abstract：:The universal 24-hour circadian clock has a profound impact on many daily biological processes. Disturbance of circadian rhythms has been implicated in the etiologies of many chronic illnesses, including cancer; with correlations most profoundly found among hormone-related breast and prostate cancers. Given the fact t...

journal_title：Medical hypotheses

authors： Zhu Y,Zheng T

更新日期：2008-01-01 00:00:00

abstract：:Consideration of nine major factors predisposing to cerebral thrombosis, coronary thrombosis or thrombosis in the deep veins of the calf, reveals that these factors all have one thing in common. Estrogen administration, pregnancy, ageing, smoking, infection, trauma, surgery, soft water and winter season are all associ...

journal_title：Medical hypotheses

authors： Clemetson CA

更新日期：1979-08-01 00:00:00

abstract：:Contrast-induced nephropathy (CIN) is regarded as acute tubular necrosis resulting from the cytotoxicity of contrast media and the medullary hypoxia linking to the interplay of vasoconstriction and vasodilatation. Saline infusion may prevent CIN by inhibiting renin release and thus production of angiotensin II (ANG II...

journal_title：Medical hypotheses

authors： Wong PC,Guo J,Zhang A

更新日期：2015-12-01 00:00:00

abstract：:The presence of the tumour induces important metabolic changes in the cancer patient which are not merely due to the fact that the tumour acts as a parasite, thus depleting the host of nutrients, but that are mainly the result of both tumoral and humoral mediators. The new metabolic status of the cancer patient may le...

journal_title：Medical hypotheses

authors： Argilés JM,López-Soriano FJ

更新日期：1998-11-01 00:00:00

abstract：:The etiology of most kinds of dementia is still obscure and is probably multifactorial. We query whether excessive watching of television may contribute to the development of dementive processes for the following reasons: TV spectators are exposed to a mass of successive and rapid stimuli with little or no possibility...

journal_title：Medical hypotheses

authors： Aronson M

更新日期：1993-11-01 00:00:00

abstract：:Homocysteine is a sulfur-containing amino acid produced by the breakdown of methionine. Plasma homocysteine levels can be elevated due to a variety of genetic and nutritional factors. Poor nutrition from diets low in folate and vitamin B12 can lead to hyperhomocysteinemia. Mildly elevated levels of homocysteine have b...

journal_title：Medical hypotheses

authors： Ferguson SE,Smith GN,Walker MC

更新日期：2001-01-01 00:00:00

abstract：:Atherosclerosis is a common disease whose complications, such as myocardial infarction, are a leading cause of mortality worldwide. Therefore, ideas which try to explain the circumstances of atherosclerotic plaque initiation and progression are warranted. We hypothesize that low-grade inflammation in early life (espec...

journal_title：Medical hypotheses

authors： Kowara M,Kasarełło K,Czarzasta K,Opolski G,Cudnoch-Jędrzejewska A

更新日期：2019-01-01 00:00:00

abstract：:Recent investigations on protease inhibitors in articular cartilage have provided new insights into the possible initial lesions of osteoarthrosis. A hypothesis has been formulated based upon an impaired ability of chondrocytes to synthesize protease inhibitors, which leads to loss of matrix integrity and vascular inv...

journal_title：Medical hypotheses

authors： Stephens RW,Ghosh P,Taylor TK

更新日期：1979-07-01 00:00:00

abstract：:Bacteria initiated peri-implantitis can lead to bone destruction around a dental implant, modifying its surface and preventing re-osseointegration. Consequently, all available methods for treating periimplantitis have disappointing long-term results. Implant failure will lead to loss of the prosthetic reconstruction a...

journal_title：Medical hypotheses

authors： Chaushu L,Shabat R,Gadyukov A,Chaushu G

更新日期：2018-12-01 00:00:00

abstract：:The two-stage initiation-progression model of cancer is widely accepted. Initiation appears to result most often from accumulation of damage to the DNA expressed as multiple mutations in the phenotype. Unsymmetrical chromosome segregation during mitosis of normal or mutated cells produces aneuploid cells and also cont...

journal_title：Medical hypotheses

authors： Parris G

更新日期：2006-01-01 00:00:00

abstract：:Alzheimer's disease is a debilitating age-related disorder characterized by distinct pathological hallmarks, such as progressive memory loss and cognitive impairment. During the last few years, several cellular signaling pathways have been associated with the pathogenesis of Alzheimer's disease, such as Notch, mTOR an...

journal_title：Medical hypotheses

authors： Bastías-Candia S,Braidy N,Zolezzi JM,Inestrosa NC

更新日期：2015-04-01 00:00:00

abstract：:Placebo controlled trials in disease states as currently constituted are designed to show a drug "works" when in fact it may not. Efficacy of this type may be constructed in trials that demonstrate some marginal superiority of a drug over placebo in disease states that do not take into account any potentialities of th...

journal_title：Medical hypotheses

authors： Healy D

更新日期：2010-05-01 00:00:00

abstract：:Both, hamstring and ACL injuries are among the most typical injuries, particularly in change of direction and high speed running sports. They're also difficult to treat. Therefore, in the past few years, sports medicine practitioners and exercise scientists have mainly been focusing on the development and implementati...

journal_title：Medical hypotheses

authors： Ertelt T,Gronwald T

更新日期：2017-11-01 00:00:00

abstract：:The per review system for the assessment of research proposals is widely respected by working scientists. Nevertheless two problems associated with the operation of this system by the US National Institutes of Health are identified. First the scientist has no control over which committee will review an application and...

journal_title：Medical hypotheses

authors： Rosenberg E

更新日期：1976-01-01 00:00:00

abstract：:The aetiology of multiple sclerosis suggests that its occurrence depends on a combination of factors, including viral infection in early childhood, genotype and an initiating event within the central nervous system. The resulting damage may be caused by events initiated by free radicals. Free radicals themselves may c...

journal_title：Medical hypotheses

authors： Cooper RL

更新日期：1997-10-01 00:00:00

abstract：:The measurement of urinary neopterin and biopterin may be an important non-specific diagnostic tool. Urinary biopterin has been found to be decreased in parkinsonian patients, and in hyperphenylalanemia as a variant of phenylketonuria. Urinary neopterin has been found to be elevated in numerous conditions. It has been...

journal_title：Medical hypotheses

authors： Rabinoff M

更新日期：1989-08-01 00:00:00