Some thoughts on the epidemiology of cardiovascular disease, (with special reference to women "on the pill"). Role of ascorbic acid.

abstract：:The hypothesis is put forward that coronary heart disease (CHD) arises from a chronic imbalance between anabolism and catabolism in the body, induced by the psychosocial environment and mediated through the central nervous system (CNS) and neuroendocrine system. Psychosocial demands increase periods of waking arousal ...

journal_title：Medical hypotheses

authors： StGeorge DP

更新日期：1983-11-01 00:00:00

abstract：:Cancer is caused by a combination of factors, genetic, epigenetics and environmental. Among the latter, environmental pollutants absorbed by contact, inhalation, or ingestion are major proven or suspected culprits. Depleted uranium (DU) is one of them directly pertinent to the military and civilians working in militar...

journal_title：Medical hypotheses

authors： Cappello F,Macario AJL

更新日期：2019-03-01 00:00:00

abstract：:It is suggested that apart from aflatoxins, plant medicinal preparations containing active compounds imperatorin, dictamine, marmesin and heraclenin may be responsible for some human cancers in Nigeria and perhaps other parts of Africa. Therefore, in this paper, a hypothesis is put forward that these compounds or thei...

journal_title：Medical hypotheses

authors： Adekunle AA,Adekunle LV

更新日期：1983-07-01 00:00:00

abstract：:It is hypothesized that Alzheimer's disease is a human phylogenetic disease which has a common multifactorial pathogenesis in sporadic and familial cases and in Down syndrome, related to a genomic character function G(x). Increments in G(x) accompanied the increased gene expression that sustained brain growth and diff...

journal_title：Medical hypotheses

authors： Rapoport SI

更新日期：1989-07-01 00:00:00

abstract：:Alzheimer's disease (AD) a neurodegenerative disorder of widely distributed cortical networks evolves over years while A beta (Aβ) oligomer neurotoxicity occurs within seconds to minutes. This disparity combined with disappointing outcomes of anti-amyloid clinical trials challenges the centrality of Aβ as principal me...

journal_title：Medical hypotheses

authors： Engel PA

更新日期：2014-12-01 00:00:00

abstract：:Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents the largest current health challenge for the society. At the moment, the therapeutic strategies to deal with this disease are only supportive. It is well known that zinc (Zn) possesses a variety of dir...

journal_title：Medical hypotheses

authors： Kumar A,Kubota Y,Chernov M,Kasuya H

更新日期：2020-11-01 00:00:00

abstract：:Many studies have focused on the detrimental effects of malnourishment to the performance of the brain and peripheral nerves. Undernourished children and adults have been studied extensively to establish these consequences. Little attention has been given to the body habitus that affects optimum neurological performan...

journal_title：Medical hypotheses

authors： Grantham J,Henneberg M

更新日期：2014-11-01 00:00:00

abstract：:Early detection of mycoplasma infection is crucial for saving precious often irreplaceable data from the tissues of patients. Mycoplasma infections cause diseases in the upper and lower respiratory tracts, urethritis in men resulting in painful dysuria, urgency and urethral discharge. Cough, fever, headache, urethriti...

journal_title：Medical hypotheses

authors： Talas L,Banfalvi G,Fidrus E,Szigeti ZM,Nagy G

更新日期：2017-10-01 00:00:00

abstract：:Alzheimer's disease (AD) may be related to nutritional deficiencies from exocrine pancreatic insufficiency (EPI) with mal-absorption of essential nutrients, vitamins and minerals. EPI occurs in about twenty percent of the elderly population, sometimes without obvious symptoms, a number similar to the incidence of AD. ...

journal_title：Medical hypotheses

authors： Brenner SR

更新日期：2017-05-01 00:00:00

abstract：:Although the role of the lymphatic circulation in the uptake of dietary fat is well established, the absorption of water-soluble compounds, secreted by the enterocyte into the lymph, has received little attention. In the present study an estimate is made of the amount of dietary glucose that can be absorbed via the ly...

journal_title：Medical hypotheses

authors： Argilés JM,Fernández-López JA,Casado J,Alemany M

更新日期：1990-11-01 00:00:00

abstract：:Infection of the lymphatic system by Wuchereria bancrofti microfilaria is the most common cause of elephantiasis, a disease that affects over 100 million people. The nightly release of microfilaria into the circulation coincides with the feeding activity of its mosquito vector, a synchronization that is presumably an ...

journal_title：Medical hypotheses

authors： Sack RL

更新日期：2009-08-01 00:00:00

abstract：:Clinical studies have shown that ionic zinc (Zn2+) dissolved in the mouth shortened manifestations of the common cold significantly, by an unknown mechanism. The observed immediate effect on symptoms is consonant with osmotic transport of Zn2+, placing a temporary chemical clamp on critical nerves. It is proposed that...

journal_title：Medical hypotheses

authors： Novick SG,Godfrey JC,Godfrey NJ,Wilder HR

更新日期：1996-03-01 00:00:00

abstract：:Ampligen, a mismatched double stranded RNA, is hypothesized to be an ideal base therapy for HIV disease to which other agents, such as the nucleoside analogue, AZT, can be advantageously added. The unique properties of Ampligen which support this hypothesis include activation of immune cells, inhibition of virus repli...

journal_title：Medical hypotheses

authors： Gillespie D,Carter WA

更新日期：1992-01-01 00:00:00

abstract：:Studies on receptor stability suggest that functional conversion of adrenoceptors between alpha and beta can occur in mammalian myocardium due to variations in the environment such as temperature changes, pH or hormonal changes. If adrenoceptors of the respiratory system behave similarly, heat and water loss of airway...

journal_title：Medical hypotheses

authors： Venugopalan CS,Jenkins HJ,Drazen JM

更新日期：1988-12-01 00:00:00

abstract：:It is proposed that gastrin promotes the uptake of divalent and trivalent metal ions from the gastrointestinal lumen by catalyzing the binding of metal ions to luminal albumin and transferrin respectively. The following observations are consistent with this hypothesis: 1. Gastrin binds both divalent and trivalent meta...

journal_title：Medical hypotheses

authors： Baldwin GS

更新日期：1992-05-01 00:00:00

abstract：:Corona virus disease 2019 (Covid-19), a pandemia emerged recently, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). The receptor for corona virus and influenza A is the mucosal cell membrane protein angiotensin converting enzyme 2 (ACE2), which is abundant on the membrane of alveolar cells and ...

journal_title：Medical hypotheses

authors： Niv Y

更新日期：2020-10-01 00:00:00

abstract：:Administration of certain drugs such as antidepressants have been shown to produce a phenomenon known as time-dependent sensitization, a process in which the acute effects of the drugs sensitize and grow over time. While both preclinical and clinical studies have demonstrated time-dependent sensitization, it is still ...

journal_title：Medical hypotheses

authors： Nathan P

更新日期：2000-06-01 00:00:00

abstract：:Several hypotheses have been developed to interpret the progression of tubulointerstitial fibrosis (TF), including senescence, epithelial-mesenchymal transition, inflammation, chronic hypoxia, and reactive oxygen species. All of these hypotheses are based on persistent cell injury and localized cell death. Proliferati...

journal_title：Medical hypotheses

authors： Chen BC,Bai YH,Tang LL,Wang BQ,Liu B,Cai Y,Peng X,Yang YR,Zheng SL

更新日期：2014-06-01 00:00:00

abstract：:The symptom spectra of several 'popular press' diagnoses are examined and compared to Diagnostic and Statistical Manual of Mental Disorders-IIIR criteria for somatization disorder, depression, and generalized anxiety disorder. While there is much overlap, there are clear distinctions, and these psychiatric terms do no...

journal_title：Medical hypotheses

authors： Elks ML

更新日期：1996-04-01 00:00:00

abstract：:This paper outlines a method of demonstrating hepatitis B virus (HBV)-related transcriptional activity based on the random amplification of cDNA ends (RACE) protocol. Following RNA extraction from the appropriate tissue, cDNA is synthesized using a long oligo d(T) based primer containing unique 5' oligonucleotide sequ...

journal_title：Medical hypotheses

authors： Sallie R

更新日期：1995-08-01 00:00:00

abstract：:Currently, several prominent researchers are investigating the role of reactive oxygen and free radicals in the activation of latent HIV in infected individuals. Early clinical applications of free radical scavengers and plant-based antioxidant systems have shown promise of efficacy in altering this process. This manu...

journal_title：Medical hypotheses

authors： Greenspan HC

更新日期：1993-02-01 00:00:00

abstract：:Geographic patterns with diminishing rates from north to south toward the equator have been described for a number of diseases, putatively related largely to "western" lifestyle. Among these the inflammatory bowel diseases; Crohn's (CD) and Ulcerative colitis (UC) have been prominent in sharing distributions with a nu...

journal_title：Medical hypotheses

authors： Szilagyi A,Xue X

更新日期：2016-11-01 00:00:00

abstract：:Ligaments are generally viewed as passive structural elements. Virtually all treatments for torn ligaments are based upon a structural paradigm. However, there is considerable evidence to suggest that ligaments function as neural sensors to facilitate supportive reflex contractions of muscles. It is hypothesized that ...

journal_title：Medical hypotheses

authors： Brand RA

更新日期：1989-08-01 00:00:00

abstract：:Infantile neuroaxonal dystrophy (INAD) and Duchenne muscular dystrophy (DMD) are two deadly neuromuscular degenerative diseases of childhood. Knowledge on their pathophysiological mechanisms may direct us towards treatment or a cure. Although these diseases are caused by two totally different gene-mutations and cause ...

journal_title：Medical hypotheses

authors： Offringa-Hup A

更新日期：2020-04-01 00:00:00

abstract：:Endemic cancer of the oesophagus in Africa is associated with the use of maize as the staple. In one African community endemic cancer of the oesophagus has been shown to have a strong statistical association with the consumption of foods based on maize in the meal form. A strong association with consumption of maize m...

journal_title：Medical hypotheses

authors： Sammon AM,Iputo JE

更新日期：2006-01-01 00:00:00

abstract：:Vitamins are indispensable nutrients for metabolism. Adequate vitamin intake plays vital role in physiological processes including embryonic development, cellular and immunity proliferation and differentiation, DNA synthesis and oxidative response. In contrast, insufficient vitamin levels usually lead to a large numbe...

journal_title：Medical hypotheses

authors： Huang Y,Liu A,Liu L,Wang B,Liang G

更新日期：2020-02-01 00:00:00

abstract：:It has been proposed that combination of indole-3-acetic acid (IAA) and horseradish peroxidase (HRP) could be useful as the basis for targeted cancer therapy involving antibody-, polymer-, or gene-directed approaches. By circulating IAA in human body, the cells labeled with HRP could be selectively killed since cytoto...

journal_title：Medical hypotheses

authors： Kawano T

更新日期：2003-05-01 00:00:00

abstract：:It has been previously proposed that conscious process involves the collapse of quantum, dynamical brain states through conscious observation. It has been further proposed that the brain process has an active role in selecting the status of uncertain stimuli. On the basis of these proposals it was predicted that event...

journal_title：Medical hypotheses

authors： Germine M

更新日期：2004-01-01 00:00:00

abstract：:Behcet's disease (BD) is a chronic, multisystem inflammatory disorder characterized by relapsing oral aphthous and genital ulcers, ocular inflammation, erythemanodosum and folliculitis-like lesions of the skin, arthritis, and central nervous system involvement. Its pathogenesis has not been fully elucidated but the et...

journal_title：Medical hypotheses

authors： Qin H,Cai J,Xu H,Gong Y

更新日期：2009-07-01 00:00:00

abstract：:Recent studies using a combination of isotope and balance techniques have shown that, in the postabsorptive state, the human kidney contributes substantially to overall glucose production and consumption. The kidney may contribute as much as the liver to gluconeogenesis and play an important role in the counterregulat...

journal_title：Medical hypotheses

authors： Stumvoll M,Meyer C,Mitrakou A,Gerich JE

更新日期：1999-05-01 00:00:00