Abstract：
:Multiple sclerosis (MS) is a neurodegenerative disease of uncertain etiology. In MS, neurodegeneration is thought to be secondary to autoimmune-mediated damage. However, no cohesive explanation yet exists as to how environmental factors interact to induce a neurodegenerative autoimmune response. Insufficient sunlight exposure and chronic viral infections have been proposed as unrelated environmental risk factors for MS. We suggest that these risk factors may act synergistically to enable the pathogenic autoimmune response. Low ultraviolet light (UVL) exposure depletes vitamin D3 stores, and low vitamin D3 levels correlate strongly with high MS risk. The central nervous system converts vitamin D3 into 1,25-dihydroxyvitamin D3 (1,25-(OH)2 D3), a biologically active hormone with anti-inflammatory and neuro-protective functions that depend on IL-10-producing regulatory lymphocytes. Herpesvirus infection also correlates with MS risk. Some herpesviruses like Epstein-Barr virus produce an IL-10-like cytokine termed vIL-10. We hypothesize that vIL-10 may induce a dysfunction of IL-10-producing regulatory lymphocytes, thereby undermining the protective functions of sunlight, vitamin D3, and 1,25-(OH)2 D3. The vIL-10 could elicit a host immune response capable of neutralizing or depleting IL-10, or the vIL-10 could compete with IL-10 but fail to perform an essential IL-10 function. In either case, the lack of sunlight exposure and the herpes virus infection might synergize to induce a defect in IL-10-producing regulatory lymphocyte function that undermines self-tolerance mechanisms and enables a pathogenic autoimmune response to neural proteins.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Hayes CE,Donald Acheson Edoi
10.1016/j.mehy.2008.01.031subject
Has Abstractpub_date
2008-01-01 00:00:00pages
85-90issue
1eissn
0306-9877issn
1532-2777pii
S0306-9877(08)00061-3journal_volume
71pub_type
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journal_title：Medical hypotheses
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1976-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 历史文章,杂志文章
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更新日期：2010-05-01 00:00:00
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journal_title：Medical hypotheses
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更新日期：2002-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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