Abstract:
:Cameron and Pauling have reported large survival increases in terminal cancer patients treated with Vitamin C. Their trials, which have been criticised because not based on random, double-blind principles, are reviewed here using a broad inductive method that relies on diverse data of varying quality. Conclusions are offered both on the value of Vitamin C and on this broad method, as follows: There is a strong possibility that Vitamin C very approximately doubled survival time as measured from the start of Vitamin C treatment, regardless of whether this was after termination of conventional treatment or much earlier. A recent Mayo Clinic trial which concluded that Vitamin C is valueless in the terminal stage may be given an alternative interpretation which supports this view. Despite a speculative element because based only on the condensed, published data, these conclusions have sufficient possibility of validity as to call for full further investigation. The conclusions on method are that the broad, inductive approach may have potential value when the randomized method cannot be used; that it also may facilitate, to the public's benefit, the release of probably valuable, inexpensive, non-toxic treatments pending decisive proof; and a greater return on the research dollar might result from a formal acceptance of the probabilistic element in scientific proof.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Jaffey Mdoi
10.1016/0306-9877(82)90089-5subject
Has Abstractpub_date
1982-01-01 00:00:00pages
49-84issue
1eissn
0306-9877issn
1532-2777pii
0306-9877(82)90089-5journal_volume
8pub_type
临床试验,杂志文章abstract::Based on the principles of the altered homeostatic theory, a case will be made that the risk of cardiovascular (CV) events from pharmaceuticals as COX-2 inhibitors (coxibs) and sympatho-mimetic drugs can be reduced significantly by using standard pharmaceutical and lifestyle preventative measures as statins, exercise,...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.05.027
更新日期:2006-01-01 00:00:00
abstract::The incidence of insulin-dependent diabetes mellitus (IDDM), a chronic disease with a well-known genetic basis, is highest in Scandinavian and Sardinian populations. The high incidence of IDDM in Scandinavia and Sardinia, which were genetically isolated from the spread of agriculturists in Europe about 8000 years ago,...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1997.0663
更新日期:1999-05-01 00:00:00
abstract::Trigeminal neuralgia is a painful condition that causes great discomfort. Although this disease has been known for more than 1000years, there is still no consensus on its underlying mechanism or treatment. Many hypotheses have been reported to explain the cause and nature of trigeminal neuralgia. These include theorie...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.01.008
更新日期:2017-03-01 00:00:00
abstract::One of the most commonly alleged contraindications to the use of (ethylene diamine tetraacetic acid) chelation therapy is possible renal damage. In this experiment, 13 subjects with chronic degenerative disorders and with renal damage were treated with infusions that included EDTA, vitamins, mineral and oral supplemen...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(84)90020-3
更新日期:1984-11-01 00:00:00
abstract::A case-control study was conducted in order to test the hypothesis that a reduced exposure to human seminal factors in the early reproductive life of women is a risk factor in breast cancer. The relative risk of exposure to the hypothetical semen-factor deficiency is 4.7 times greater for breast-cancer patients than f...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(78)90051-8
更新日期:1978-03-01 00:00:00
abstract::Computer algorithms can only produce seemingly random or pseudorandom numbers whereas certain natural phenomena, such as the decay of radioactive particles, can be utilized to produce truly random numbers. In this study, the ability of humans to generate random numbers was tested in healthy adults. Subjects were simpl...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.02.019
更新日期:2005-01-01 00:00:00
abstract::Benign intracranial hypertension and communicating hydrocephalus are uncommon but important disorders that affect cerebrospinal fluid dynamics. They have clinical similarities but their management is usually different. The factors determining which of the two disorders will develop include brain compliance, the state ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(97)90081-5
更新日期:1997-11-01 00:00:00
abstract::Temporomandibular joint (TMJ) ankylosis is a disease that severely affects the human health. Although it is well known that trauma is the most common cause of TMJ ankylosis, the mechanisms by which the traumatic TMJ ankylosis develops are unclear. The existing hypothesis is not convincing in explaining the genesis of ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.01.024
更新日期:2009-07-01 00:00:00
abstract::The secretion of Follicle Stimulating Hormone by the pituitary gland is not regulated entirely by the negative feedback from gonadal steroids. There is ample evidence that the secretion of FSH is regulated by a non-steroidal hormone of gonadal origin termed "inhibin". Using a radioimmunoassay procedure, immunoreactive...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(84)90119-1
更新日期:1984-10-01 00:00:00
abstract::Bone and cartilage are major weight-bearing connective tissues in human and possesses utmost vulnerability for degeneration. The potential causes are mechanical trauma, cancer and disease condition like osteoarthritis and osteoporosis, etc. The regeneration/repair is a challenging, since their complex structures and a...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.07.021
更新日期:2017-10-01 00:00:00
abstract::Medical Hypotheses exists to give ideas and speculations in medicine a fair hearing. Doing this is not easy. Most conventional journals would regard some of what is published here as questionable, most referees would reject it as 'unproven'. We have more liberal standards, for reasons we have presented before. But we ...
journal_title:Medical hypotheses
pub_type: 社论
doi:10.1016/j.mehy.2004.10.003
更新日期:2005-01-01 00:00:00
abstract::An aldehyde-dehydrogenase (ALDH2) deficiency is a biological curb on excess alcohol-drinking. This enzyme deficiency is very common amongst Oriental people while it is relatively rare for most other populations. We observe that there is good geographical correlation between the prevalence of the mutant ALDH2*2 alleles...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(02)00253-0
更新日期:2002-08-01 00:00:00
abstract::Natural objects, live and inanimate, actively maintain their entities by using their capacities (i.e., properties, internal resources, mechanisms, and experience) adequately to their needs. It is suggested that the principle of adequate function is a law of nature. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(86)90078-2
更新日期:1986-03-01 00:00:00
abstract::Multiple sclerosis (MS) is a neurodegenerative disease of uncertain etiology. In MS, neurodegeneration is thought to be secondary to autoimmune-mediated damage. However, no cohesive explanation yet exists as to how environmental factors interact to induce a neurodegenerative autoimmune response. Insufficient sunlight ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.01.031
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:No method is currently available for preoperative approximation of the patient's situation to the one existing during pneumonectomy in general anesthesia with alternations of single and double-lung ventilation in the lateral position. We hypothesized that a patient breathing the room air in the sitting posit...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.07.003
更新日期:2011-10-01 00:00:00
abstract::In the present study, we used the potential of bioinformatics and computational analysis to predict the existence and biological relevance of zinc finger (ZF) motifs in heamagglutinin (HA) protein of Avian Influenza (AI) virus. Sequence data of Avian Influenza (AI) viruses were retrieved from accessible databases (Gen...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109925
更新日期:2020-11-01 00:00:00
abstract::It is estimated that about 1 million patients are hospitalized for acute coronary events each years in the United States. An acceptable theory is that the acute coronary syndrome is caused by rupture of the atherosclerotic plaque with superimposed thrombus, which is a complex process and involving a number of differen...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.06.018
更新日期:2005-01-01 00:00:00
abstract::HIV may induce subclinical neuroendocrine dysfunctions in some seropositive patients and these dysfunctions may be one of the co-factors that determine the pathogenesis of AIDS. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(88)90090-4
更新日期:1988-09-01 00:00:00
abstract::Myocardial ischemia/reperfusion injury (I/RI) is the principal cause of mortality and morbidity in diabetic patients undergoing cardiac surgery. However, there is no specific measure available to protect diabetic hearts in this clinical setting. Our clinical studies showed that adenosine pre-treatment or post-treatmen...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.06.022
更新日期:2012-10-01 00:00:00
abstract::Shear wave sonoelastography is a valuable additional technique in differentiation between benign and malignant breast lesions. In this paper, a hypothesis of the potential role of this additional ultrasound technique as a very useful tool in differentiation of a medullary breast cancer subtype is proposed. Medullary b...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.110021
更新日期:2020-11-01 00:00:00
abstract::This paper will show that the fractional difference in the human gender ratio (GR) between the GR(at death) for those born in solar cycle peak years (maxima) and the GR(at death) in those born in solar cycle non-peak years (minima), e.g., 0.023, divided by Pi, yields a reasonable approximation of the quantum mechanica...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.03.028
更新日期:2009-09-01 00:00:00
abstract::Chronic active Epstein-Barr virus (EBV) infection has been recognized as clonal non-neoplastic lymphoproliferative diseases. However, some reports of cases with a multiphenotypic expansion of EBV-infected lymphocytes give rise to questions of how EBV infects multiphenotypic lymphocytes and whether chronic active EBV i...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.03.012
更新日期:2004-01-01 00:00:00
abstract::Cerebral ischemia is still one of the most confusing and enigmatic neurological disorders with least understood injuries. The EEG measures have been traditionally used to detect residual neural dysfunctions after cerebral ischemia although having several shortcomings, yielding controversial and inconsistent results. I...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.06.002
更新日期:2013-09-01 00:00:00
abstract::Focal epilepsy secondary esp to scar or injured cortical tissue forms a source of constant depolarisation site with or without emitting negative charges (current of injury) into the surrounding area. This focal site is localised by EEG, MRI and if required, by PET and/or SPECT studies. The author postulates to implant...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(02)00266-9
更新日期:2002-11-01 00:00:00
abstract::The thickness of the choroid is measured on the optical coherence tomography (OCT) as the distance between the hyperreflective retinal pigment epithelium and the hyperreflective chorio-scleral junction, contributed by the choroidal vessels and choroidal melanocytes. Our hypothesis is that the amount of absorption and ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.110408
更新日期:2021-01-01 00:00:00
abstract::In a previous paper we predicted that health effects of dietary fats in humans would require half a century or more to be understood, instead of the decade or so predicted during 1956 by an Editorial in The Lancet. It would seem that our prediction may have been optimistic since it has now been reported that trans uns...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(92)90194-h
更新日期:1992-04-01 00:00:00
abstract::The 'Big Bang' is used to describe the origin of the Universe. While such an event could not create itself the expression is graphic. Tissue damage, traumatic, thermal, chemical; bites; insect, animal or human are all bad, but also well known factors which favor and initiate pathogenic activity. Antedating and outrank...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(91)90036-x
更新日期:1991-06-01 00:00:00
abstract::A five-step hypothesis on the pathogenesis of Hodgkin's disease (HD) is presented. Weak immune suppressor activity gives a predisposition for the development of the disease, after which a non-specific immune stimulation can initiate a self-perpetuating uncontrolled stimulation between interdigitating cells (IDCs), mac...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(84)90156-7
更新日期:1984-12-01 00:00:00
abstract::Bone grafting uses a wide range of materials derived mainly from exogenous sources. Autogenous teeth are often used fresh or fixed with alcohol for later use. Proposed here is a method of using cryogenically preserved autogenous extracted teeth, which could be macerated after thawing. This method avoids the possibilit...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.04.028
更新日期:2016-07-01 00:00:00
abstract::Homeostasis, or the maintenance of constant internal environment in the organism, is disrupted by injury. In this case, pathological defence reactions such as inflammation and healing take place in order to restore it. They succeed if etiological harmful factors are eliminated. In the opposite case, constant injury le...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(91)90247-v
更新日期:1991-10-01 00:00:00