On the general theory of neural circuitry.

abstract：:A lowered risk of multiple sclerosis (MS) has been reported in the Hutterite community residing mainly in southern Canada. In another anabaptist community, the Old Colony Mennonites (OCM), settled in Canada and spread to Latin America, only a large pedigree with an increased risk of autoimmune diseases, including type...

journal_title：Medical hypotheses

authors： Lauer K

更新日期：2006-01-01 00:00:00

abstract：:It is suggested that the Persian Gulf Syndrome (PGS) is caused by beef allergy. In the first symptomless phase, as a result of an energetic US Army immunizing program, using sera with adjuvants to produce detectable antibody levels, the subjects not only developed immunity to the targeted substances, but also became s...

journal_title：Medical hypotheses

authors： Hollander DH

更新日期：1995-09-01 00:00:00

abstract：:Most cancer cells differ from normal cells in that they show higher beta-glucuronidase activity and lower pH of their cytoplasm. Anti-cancer drugs can be designed which take advantage of these gradients to deliver maximal toxicity to tumors and minimal toxicity to normal tissue. Many design criteria are suggested here...

journal_title：Medical hypotheses

authors： Rubin DM,Rubin EJ

更新日期：1980-01-01 00:00:00

abstract：:In attempts to develop a rational anticancer strategy the same homologous tissue in 3 conditions were used side by side as targets: normal epidermis of the mouse back. Tween 60R-provoked benign epidermal hyperplasia, and carcinogen-provoked malignant condition. In contrast to the highest tolerated doses of the cytosta...

journal_title：Medical hypotheses

authors： Setälä K

更新日期：1982-03-01 00:00:00

abstract：:The authors hypothesize that the impairment of hypothalamic-pituitary-gonadal axis in patients suffering from anorexia nervosa depends (at least in part) on the increased sensitivity to endogenous melatonin. The hypothesis is based mainly on the following facts: (1) melatonin is well known to exert an inhibitory effec...

journal_title：Medical hypotheses

authors： Pawlikowski M,Zarzycki J

更新日期：1999-02-01 00:00:00

abstract：:Dietary chromium supplementation for the treatment of diabetes remains controversial. The prevailing view that chromium supplementation for glucose regulation is unjustified has been based upon prior studies showing mixed, modest-sized effects in patients with type 2 diabetes (T2DM). Based on chromium's potential to i...

journal_title：Medical hypotheses

authors： Brownley KA,Boettiger CA,Young L,Cefalu WT

更新日期：2015-07-01 00:00:00

abstract：:Women with polycystic ovary syndrome (PCOS) have been shown to have a higher incidence of cancer. It is suggested that several factors, including hyperinsulinemia, dyslipidemia, raised estrogen levels, chronic inflammation, and reduced apoptosis are responsible for this association. However, in this paper we propose t...

journal_title：Medical hypotheses

authors： Mravec B,Tibensky M

更新日期：2020-01-01 00:00:00

abstract：:Retinopathy of prematurity (ROP) is a disease of the immature retina and is the leading global cause of blindness in children. Two postnatal phases of the disease are distinguished, the first phase is thought to be caused by hyperoxia. One of the most relevant ROP risk factor in routine clinical practice is blood tran...

journal_title：Medical hypotheses

authors： Podraza W

更新日期：2020-04-01 00:00:00

abstract：:Many experimental, clinical and epidemiological data indicate that n-3 and n-6 essential fatty acids are therapeutic nutrients which may delay the development as well as improve the course of cancer. The present hypothesis correlates well with these data and it is proposed that chronic essential fatty acid deficiency,...

journal_title：Medical hypotheses

authors： Eynard AR

更新日期：1997-01-01 00:00:00

abstract：:Atrial fibrillation (Af) is the most common disorder of cardiac rhythm and is responsible for substantial morbidity and mortality in the general population. A recent community-based observational study revealed that diabetes and hypertension were associated with the development of Af. Since there is no definite eviden...

journal_title：Medical hypotheses

authors： Yamagishi S,Takenaka K,Inoue H

更新日期：2006-01-01 00:00:00

abstract：:Personality trait research has shown associations with many genes, prominently those of the catecholamine metabolism such as dopamine beta hydroxylase (DBH), catechol-O-methyltransferase (COMT), and monoamine oxidase A (MAOA). Because DBH gene is in linkage disequilibrium with ABO gene, there is reason to think that o...

journal_title：Medical hypotheses

authors： Hobgood DK

更新日期：2011-08-01 00:00:00

abstract：:A comparison of more important physical, chemical and biological properties of the nitric oxide (NO) and free stable nitroxyl radicals (nitroxides) on the base of their structural similarity is made in the article. The active moiety in the nitroxide molecule represents a sterically hindered nitric oxide. The mechanism...

journal_title：Medical hypotheses

authors： Raikov ZD,Raikova ET,Atanasov AT

更新日期：2001-09-01 00:00:00

abstract：:Yawning is a stereotyped event that occurs in humans and animals from fish to mammals, but neither its mechanisms nor its functions are entirely known. Its widespread nature suggests that it has important physiological functions. It is associated with stretching of muscles in a large area, but the function of this str...

journal_title：Medical hypotheses

authors： Matikainen J,Elo H

更新日期：2008-01-01 00:00:00

abstract：:The authors present an extended version of Clark's and Ariëns's classical theory that enables the interpretation and quantitative characterization of dose-response curves which are not in accordance with classical theory. Being supported by the chemical receptor theory, the new model expands its applicability to two o...

journal_title：Medical hypotheses

authors： Várkonyi P,Gabányi Z,Körmöczy P

更新日期：1985-04-01 00:00:00

abstract：:Meditation is used worldwide by millions of people for relaxation and stress relief. Given sufficient practice, meditators may also experience a variety of altered states of consciousness. These states can lead to a variety of unusual experiences, including physical, emotional and psychic disturbances. This paper high...

journal_title：Medical hypotheses

authors： Lindsay S

更新日期：2014-10-01 00:00:00

abstract：:The outbreak of coronavirus disease 2019 (COVID-19) has posed a severe threat to global health management system since it has been detected in the human body. This pandemic was prompted by severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2) and rapidly developed into a public emergency with an alarming incr...

journal_title：Medical hypotheses

authors： Tao H,Bai J,Zhang W,Zheng K,Guan P,Ge G,Li M,Geng D

更新日期：2020-11-01 00:00:00

abstract：:In this work a new theory of acoustic signal detection in the inner ear and an experimental explanation of the causes of bifilar cochlear structure was presented. Our innovative approach describes sound detection in a completely different way from the one currently adopted. It requires analyzing the inner ear system i...

journal_title：Medical hypotheses

authors： Dora J,Wojcieszak D,Kaczmarek D,Mazur M,Aksenczuk A

更新日期：2020-02-18 00:00:00

abstract：:Autism may be a disorder linked to the disruption of the G-alpha protein, affecting retinoid receptors in the brain. A study of 60 autistic children suggests that autism may be caused by inserting a G-alpha protein defect, the pertussis toxin found in the DPT vaccine, into genetically at-risk children. This toxin sepa...

journal_title：Medical hypotheses

authors： Megson MN

更新日期：2000-06-01 00:00:00

abstract：:Seroepidemiological, clinical and molecular findings suggest that the acquired immune deficiency syndrome virus human immunodeficiency virus-1 was introduced into the human species at the time (late 1950s) and in the geographic area (Zaire) in which millions of Africans were vaccinated with attenuated poliomyelitis vi...

journal_title：Medical hypotheses

authors： Reinhardt V,Roberts A

更新日期：1997-05-01 00:00:00

abstract：:What causes cancer? To date, this question is left with no answer. The scientific community keeps defining cancer as a proliferation of cells in an uncontrolled and uncontrollable manner. The hypothesis developed here through an understanding of the cancer cell's behaviour led to its re-definition, providing answers t...

journal_title：Medical hypotheses

authors： Majerus MA

更新日期：2002-06-01 00:00:00

abstract：:Mouth to mouth sexual kissing is seen in more than 90% of human cultures. Various theories have been put forward to account for this but none offer a full explanation within an evolutionary framework. As mouth to mouth sexual kissing exposes each participant to the diseases of the other, it must confer significant ben...

journal_title：Medical hypotheses

authors： Hendrie CA,Brewer G

更新日期：2010-02-01 00:00:00

abstract：UNLABELLED:CRPS is an acute pain disease expressed as chronic pain with a severe loss of tissue and function. CRPS usually occurs after minor injuries and then progresses in a way that is scarcely controllable, or completely uncontrollable. This article addresses the functional control mechanism of a biological organis...

journal_title：Medical hypotheses

authors： van der Veen P

更新日期：2015-11-01 00:00:00

abstract：:Based on a logic of balance mechanisms influencing information processing in tripartite synapses are proposed. It is hypothesized that the number of expressed astrocytic receptors determines balanced and imbalanced synaptic states. Synaptic information processing in mental disorders is underbalanced in depression, ove...

journal_title：Medical hypotheses

authors： Mitterauer BJ

更新日期：2015-04-01 00:00:00

abstract：:Sudden infant death syndrome (SIDS) is frequently associated with a mild infection, the incidence peaking during the third month of life. We hypothesize that the neonatal immaturity of both the acute febrile response and hypothalamus promote neonatal protection from SIDS. Vagal afferents modify the febrile response. V...

journal_title：Medical hypotheses

authors： Reid GM,Tervit H

更新日期：1999-06-01 00:00:00

abstract：:Cancer and other diseases may be a natural biological event, the activities of which may be dependent on the constitution of the individual. Where fetal and embryonic cells are not diseased or faulty or defective, they may be useful as therapies against cancer and other diseases. ...

journal_title：Medical hypotheses

authors： Caesar G

更新日期：2002-05-01 00:00:00

abstract：:It is increasingly admitted that Crohn's disease and ulcerative colitis, the two entities of inflammatory bowel disease, are initiated and reactivated by environmental factors in genetically susceptible hosts, and result from aberrant immune response to specific intestinal microbes, in the context of altered compositi...

journal_title：Medical hypotheses

authors： Beaugerie L,Langholz E,Nyboe-Andersen N,Pigneur B,Sokol H,ECCO Epicom.

更新日期：2018-06-01 00:00:00

abstract：:"Consciousness" "mood," "identity" and "personality" are all emergent properties from whole-brain organizations; these are typically disturbed in psychiatric disorders. This work proposes that the underlying etiopathology of mental disorders originates from disturbances to global brain dynamics, or "Globalopathies" th...

journal_title：Medical hypotheses

authors： Peled A

更新日期：2013-12-01 00:00:00

abstract：:Oral glucosamine has anti-inflammatory activity in rodents, and anecdotal evidence suggests that it may be clinically useful in inflammatory bowel disorders. A possible explanation is that supplemental glucosamine increases production of heparan sulfate (HS) proteoglycans by the vascular endothelium, thereby improving...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：1998-07-01 00:00:00

abstract：:Melasma is an acquired disorder of pigmentation that presents with asymptomatic symmetric darkening of the face. The pathogenesis of this condition is multifactorial and influenced by several factors including female sex hormones, genetic predisposition and ultraviolet light exposure. The management of melasma is usua...

journal_title：Medical hypotheses

authors： Cohen PR

更新日期：2017-04-01 00:00:00

abstract：:A consistent accumulation of experimental evidence, most of it published long ago, clearly shows that a constant consequence of the immune response elicited by the Koch bacillus is that the individual becomes susceptible to be injured or killed by the tuberculous antigen, which is totally innocuous to the virgin subje...

journal_title：Medical hypotheses

authors： Rivarola AJ

更新日期：1987-08-01 00:00:00