Deep brain stimulation of the pedunculopontine tegmental nucleus may influence renal function.

abstract：:The existence of homosexuality in humans poses a problem for evolutionary theory. Exclusive male homosexuality has a catastrophic effect on reproduction and yet inherited factors appear to contribute to it. Previous attempts to resolve this conundrum are inconsistent with aspects of evolutionary theory. Additional lim...

journal_title：Medical hypotheses

authors： Dewar CS

更新日期：2003-02-01 00:00:00

abstract：:A five-step hypothesis on the pathogenesis of Hodgkin's disease (HD) is presented. Weak immune suppressor activity gives a predisposition for the development of the disease, after which a non-specific immune stimulation can initiate a self-perpetuating uncontrolled stimulation between interdigitating cells (IDCs), mac...

journal_title：Medical hypotheses

authors： Zwitter M

更新日期：1984-12-01 00:00:00

abstract：:There are many published studies about the epigenetic effects of the prenatal and infant periods on health outcomes. However, there is very little knowledge regarding the effects of the intrapartum period (labor and birth) on health and epigenetic remodeling. Although the intrapartum period is relatively short compare...

journal_title：Medical hypotheses

authors： Dahlen HG,Kennedy HP,Anderson CM,Bell AF,Clark A,Foureur M,Ohm JE,Shearman AM,Taylor JY,Wright ML,Downe S

更新日期：2013-05-01 00:00:00

abstract：:"Consciousness" "mood," "identity" and "personality" are all emergent properties from whole-brain organizations; these are typically disturbed in psychiatric disorders. This work proposes that the underlying etiopathology of mental disorders originates from disturbances to global brain dynamics, or "Globalopathies" th...

journal_title：Medical hypotheses

authors： Peled A

更新日期：2013-12-01 00:00:00

abstract：:Several studies have demonstrated the existence of morphological, biological, genetic and antigenic correlations between human and animal retroviruses. Furthermore, some agents of bovine and feline origin can also be considered useful comparative models for the pathogenetic study of human diseases such as leukaemia, a...

journal_title：Medical hypotheses

authors： Di Guardo G

更新日期：1989-07-01 00:00:00

abstract：:Hypnosis and music interventions (HMIs) have shown positive influence on cancers for nearly 200years, but the underlying mechanisms were rarely explored systematically. The hypothesis suggests a potential curative efficacy of HMIs on cancers by inhibiting hypoxia inducible factor-1 (HIF-1), which is a key mediator of ...

journal_title：Medical hypotheses

authors： Wang JZ,Li L,Pan LL,Chen JH

更新日期：2015-11-01 00:00:00

abstract：:Clinical studies have shown that ionic zinc (Zn2+) dissolved in the mouth shortened manifestations of the common cold significantly, by an unknown mechanism. The observed immediate effect on symptoms is consonant with osmotic transport of Zn2+, placing a temporary chemical clamp on critical nerves. It is proposed that...

journal_title：Medical hypotheses

authors： Novick SG,Godfrey JC,Godfrey NJ,Wilder HR

更新日期：1996-03-01 00:00:00

abstract：:Glaucoma is the leading cause of irreversible blindness worldwide, which is now viewed as a disease of brain with pathogenesis not fully understood. The main diagnostic methods are examining the retinal nerve fiber layer through optical coherence tomography and investigating visual field defect, but these methods pres...

journal_title：Medical hypotheses

authors： Sun Y,Huang W,Li F,Li H,Wang L,Huang Y,Zhang X

更新日期：2019-02-01 00:00:00

abstract：:Despite all improvements in transplant medicine, renal transplant recipients have a high risk for cardiovascular mortality. A high prevalence of cardiovascular complications in renal transplant recipients (RTR) is explained by cardiovascular risk factors present before transplantation, in addition to the development o...

journal_title：Medical hypotheses

authors： Mikolasevic I,Racki S,Lukenda V,Pavletic-Persic M,Milic S,Orlic L

更新日期：2014-01-01 00:00:00

abstract：:Cancer and other diseases may be a natural biological event, the activities of which may be dependent on the constitution of the individual. Where fetal and embryonic cells are not diseased or faulty or defective, they may be useful as therapies against cancer and other diseases. ...

journal_title：Medical hypotheses

authors： Caesar G

更新日期：2002-05-01 00:00:00

abstract：:The autoimmune disease rheumatoid arthritis (RA) presents difficulty in diagnosis, commonly observed flare ups, polycyclical nature of RA progression, and variable response to therapies. Congruent with multiple causes, literature has documented various infectious agents, environmental factors, physical trauma, silica ...

journal_title：Medical hypotheses

authors： Molnar-Kimber KL,Kimber CT

更新日期：2012-01-01 00:00:00

abstract：:Limbic associated pelvic pain is a proposed pathophysiology designed to explain features commonly encountered in patients with chronic pelvic pain, including the presence of multiple pain diagnoses, the frequency of previous abuse, the minimal or discordant pathologic changes of the involved organs, the paradoxical ef...

journal_title：Medical hypotheses

authors： Fenton BW

更新日期：2007-01-01 00:00:00

abstract：:It is estimated that about 1 million patients are hospitalized for acute coronary events each years in the United States. An acceptable theory is that the acute coronary syndrome is caused by rupture of the atherosclerotic plaque with superimposed thrombus, which is a complex process and involving a number of differen...

journal_title：Medical hypotheses

authors： Fang CH,Li JJ,Hui RT

更新日期：2005-01-01 00:00:00

abstract：:An unacceptably high incidence of preterm labour is seen in the black and coloured communities of South Africa. This hypothesis proposes that sodium-potassium adenosine triphosphatase activity plays an important role in preterm labour. The impaired activity of the sodium pump leads to increased cytosolic calcium level...

journal_title：Medical hypotheses

authors： Du Toit PJ,Theron JJ,Grobler AS,Steinmann CM,Van Papendorp DH

更新日期：1996-09-01 00:00:00

abstract：:Following observation of fatigue syndromes in people who have been occupationally exposed to pesticides and insecticides which exert their toxicity through the GABAa receptor, we have formulated the hypothesis that fatigue syndromes in general may be secondary to altered sensitivity of the GABAa receptor. We discuss t...

journal_title：Medical hypotheses

authors： Corrigan FM,MacDonald S,Brown A,Armstrong K,Armstrong EM

更新日期：1994-10-01 00:00:00

abstract：:The number of patients with diabetes has been expected around 300 million by 2025 and 366 million by 2030 by WHO. On the other hand, diabetic wounds as one of the common complications of diabetes represent major health challenges. Recently, wound care biological products have been proposed for treatment of chronic wou...

journal_title：Medical hypotheses

authors： Larijani B,Ghahari A,Warnock GL,Aghayan HR,Goodarzi P,Falahzadeh K,Arjmand B

更新日期：2015-06-01 00:00:00

abstract：:Plantar fasciitis has been and remains one of the most common pathologic conditions of the lower extremity. Patients diagnosed with plantar fasciitis are treated conservatively with various degrees of success. This article presents a review of the literature pertaining to treatment of plantar fasciitis as well as intr...

journal_title：Medical hypotheses

authors： Dmitri Luke BS

更新日期：2002-07-01 00:00:00

abstract：:The blockage of a vena cava filter (VCF) by the captured blood clots presents a serious problem to the patients. Commercially available cone-shaped VCFs such as the Gunther Tulip filter has an inherent structural flaw that leads the captured blood clots to be trapped in their front spire areas where the flow-induced s...

journal_title：Medical hypotheses

authors： Chen Z,Fan Y,Deng X

更新日期：2011-12-01 00:00:00

abstract：:Proteins are assumed to contain all the information necessary for unambiguous folding and specific interaction with each other. However, ab initio structure prediction is often not successful because the amino acid sequence itself is simply not sufficient to guide between endless folding possibilities. It seems to be ...

journal_title：Medical hypotheses

authors： Biro JC

更新日期：2006-01-01 00:00:00

abstract：:NETosis, being an alternative form of cell death is the creation of web-like chromatin decondensates by suitably primed neutrophils as a response to stimulus aimed at containing and eliminating the same. In certain situations, it causes more harm than benefit in the form of bystander damage directly or via activation ...

journal_title：Medical hypotheses

authors： Gupta S,Sahni V

更新日期：2020-11-01 00:00:00

abstract：:According to the theory presented herewith, neoplasia results solely from stem cell depletion. Besides serving as tissue progenitors, stem cells are postulated to secrete a vital substance 'A' necessary for proper tissue function. Carcinogens interfere with 'A' production mainly by destroying stem cells and since the ...

journal_title：Medical hypotheses

authors： Zajicek G

更新日期：1985-11-01 00:00:00

abstract：:Most cancer cells differ from normal cells in that they show higher beta-glucuronidase activity and lower pH of their cytoplasm. Anti-cancer drugs can be designed which take advantage of these gradients to deliver maximal toxicity to tumors and minimal toxicity to normal tissue. Many design criteria are suggested here...

journal_title：Medical hypotheses

authors： Rubin DM,Rubin EJ

更新日期：1980-01-01 00:00:00

abstract：:An expansion of the 'stable' gene hypothesis proposed previously is the hypothesis that there is a range of genes, some proto-oncogenes and some not, varying from those with multiple copies in the genome, wide distribution among species, and limited mutability because of a specific protective stabilizing mechanism of ...

journal_title：Medical hypotheses

authors： Frei JV

更新日期：1995-02-01 00:00:00

abstract：:Recently, the concept of drug delivery requires that the release of encapsulated drug be produced only at the diseased site with controllable rates. Given that thermosensitive hydrogels have been widely investigated for controlled delivery based on their phase transition, we speculate that nanoparticles with the novel...

journal_title：Medical hypotheses

authors： Li J,Wang B,Liu P

更新日期：2008-08-01 00:00:00

abstract：:Music is ubiquitous. Yet, its biological relevance is still an ongoing debate. Supporting the view that music had an ancestral role in courtship displays, a pilot study presented here provides preliminary evidence on the link between music and sexual selection. The underlying hypothesis is based on the fact that the s...

journal_title：Medical hypotheses

authors： Miani A

更新日期：2016-08-01 00:00:00

abstract：:Narcolepsy type 1 is a lifelong sleep disorder characterized by the loss of hypocretin-producing neurons in the brain. Environmental agents, including influenza, neurotoxic metals, and combustion smoke, have been implicated in the pathogenesis, especially in carriers of the human leukocyte antigen class II DQB1*06:02 ...

journal_title：Medical hypotheses

authors： Mori I

更新日期：2019-10-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Medical hypotheses

authors： Dillon SP,Kurien BT,Maier-Moore JS,Wiley GB,Gaffney PM,Scofield RH

更新日期：2012-08-20 00:00:00

abstract：:Hypoxic-ischemic brain injury is an important cause of neonatal mortality and subsequent serious neurological sequel. In neonatal brain the severity of hypoxic injury varies most probably due to the effects of multiple protective or deleterious factors. But the mechanisms under this difference are still not full under...

journal_title：Medical hypotheses

authors： Kumral A,Tuzun F,Yesilirmak D,Duman N,Ozkan H

更新日期：2009-06-01 00:00:00

abstract：:It has long been recognized that the symptom complex of fibromyalgia can be seen with hypothyroidism. Hypothyroidism may been categorized, like diabetes, into type I (hormone deficient) and type II (hormone resistant). Most cases of fibromyalgia fall into the latter category. The syndrome is reversible with treatment,...

journal_title：Medical hypotheses

authors： Garrison RL,Breeding PC

更新日期：2003-08-01 00:00:00

abstract：:Exercise is thought to have considerable potential as a preventive for osteoporosis. We critically examined 27 studies that address the prophylactic role of exercise in osteoporosis. The results from both cross-sectional and longitudinal studies showed that differences in bone mass were more pronounced in the axial sk...

journal_title：Medical hypotheses

authors： Block JE,Smith R,Friedlander A,Genant HK

更新日期：1989-09-01 00:00:00