A book of ideas collected from Medical Hypotheses: Death can be cured by Roger Dobson.

Abstract:

:A new collection of ideas from Medical Hypotheses by Roger Dobson is entitled Death can be cured and 99 other Medical Hypotheses. It consists of humorous summaries of Medical Hypotheses articles from the past 30 years. The book's humour derives mainly from the subject matter, although sometimes also from the 'unconventional' approach of the authors with respect to matters such as evidence, argument or inference. Medical Hypotheses has generated such a lot of apparently- or actually-bizarre ideas because it aims to be open to potentially revolutionary science. The journal's official stance is that more harm is done by a failure to publish one idea that might have been true, than by publishing a dozen ideas that turn out to be false. Bizarre ideas tend to catch attention, and may stimulate a valuable response--even when a paper is mostly-wrong. A paper may be flawed but still contain the germ of an idea that can be elaborated and developed. The journal review process is susceptible to both false positives and false negatives. False positives occur when we publish an idea that is wrong; false negatives occur when we fail to publish an important idea that is right, and a potential scientific breakthrough never happens. False positives are more obvious, since the paper will be ignored, refuted, or fail to be replicated--and often attracts criticism and controversy. Editors may therefore take the more cautious path of avoiding false positives more assiduously than false negatives; however, this policy progressively favours less-ambitious science. Consequently, in Medical Hypotheses the 'set point' of risk is nearer to the false positive end of the spectrum than for most journals - and the publication of many apparently-bizarre papers is a natural consequence of this policy.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Charlton BG

doi

10.1016/j.mehy.2008.01.016

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

905-9

issue

5

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(08)00027-3

journal_volume

70

pub_type

社论
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    authors: Stumvoll M,Meyer C,Mitrakou A,Gerich JE

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    abstract::Exercise is a key component for prevention and treatment of type 2 diabetes. However, diabetes complications affect exercise habits. Computerized clinical decision support systems (CCDSSs) may help specialists improve their decision-making abilities in the management of diseases. We hypothesized that patients' diabeti...

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    abstract:BACKGROUND:No method is currently available for preoperative approximation of the patient's situation to the one existing during pneumonectomy in general anesthesia with alternations of single and double-lung ventilation in the lateral position. We hypothesized that a patient breathing the room air in the sitting posit...

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    authors: Subotic D,Ercegovac M,Mandaric D,Herth F,Andric Lj,Gajic M

    更新日期:2011-10-01 00:00:00

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    abstract::A new approach to antiviral therapy is proposed, taking advantage of the recently investigated innervation of immune tissues by the sympathetic nervous system, which establishes a functional connection between the nervous and the immune system, where the sympathetic nervous system exerts a varying tonic inhibitory inf...

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    doi:10.1016/0306-9877(95)90097-7

    authors: Peuschel KE

    更新日期:1995-10-01 00:00:00

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    abstract::Consideration of nine major factors predisposing to cerebral thrombosis, coronary thrombosis or thrombosis in the deep veins of the calf, reveals that these factors all have one thing in common. Estrogen administration, pregnancy, ageing, smoking, infection, trauma, surgery, soft water and winter season are all associ...

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    authors: Clemetson CA

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    abstract::The author presents evidence from published papers of research done by numerous investigators that Multiple Sclerosis (MS) is an autoimmune disease, that the target tissue is the myelin sheath which covers the nerve fibers in the brain and spinal cord, that Myelin Basic Protein (MBP) is the antigen or one of the antig...

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    doi:10.1016/0306-9877(88)90061-8

    authors: Eidinoff H

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    abstract::The constant level of various proteins including albumin and cellular components in intravascular pool in vivo is strictly controlled by an unknown homeostatic mechanism, although there are fluctuations seen in pathologic conditions. Because the majority of the IgG in the serum is regarded as self-reactive natural aut...

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    doi:10.1016/j.mehy.2006.04.011

    authors: Lee KY,Lee JS

    更新日期:2006-01-01 00:00:00

  • Construction of a bispecific antisense oligonucleotide containing multiple binding sites for the treatment of hormone insensitive prostate tumors.

    abstract::Antisense oligonucleotides (oligos) have demonstrated efficacy for the treatment of various cancers, infectious diseases and metabolic disorders. While most studies have utilized single oligos either administered alone, or more recently in combination therapy with other drugs, some investigators have administered more...

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    pub_type: 杂志文章

    doi:10.1016/j.mehy.2004.12.032

    authors: Rubenstein M,Tsui P,Guinan P

    更新日期:2005-01-01 00:00:00

  • Pellagra: A clue as to why energy failure causes diseases?

    abstract::Pellagra is a curable dietary illness that unchecked leads to dementia, diarrhoea, dermatitis and death due to lack of the precursors for NAD(H). In addition it caused a wide range of monosyndromic degenerative and functional neurological disorders as well as profound developmental, premature aging and metabolic syndr...

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    pub_type: 杂志文章

    doi:10.1016/j.mehy.2007.01.029

    authors: Williams AC,Ramsden DB

    更新日期:2007-01-01 00:00:00

  • Each type of cause that initiates rheumatoid arthritis or RA flares differentially affects the response to therapy.

    abstract::The autoimmune disease rheumatoid arthritis (RA) presents difficulty in diagnosis, commonly observed flare ups, polycyclical nature of RA progression, and variable response to therapies. Congruent with multiple causes, literature has documented various infectious agents, environmental factors, physical trauma, silica ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2011.10.006

    authors: Molnar-Kimber KL,Kimber CT

    更新日期:2012-01-01 00:00:00

  • Can we find a solution to the human immunodeficiency virus/acquired immune deficiency syndrome controversy? Is acquired immune deficiency syndrome the consequence of continuous excessive stressing of the body?

    abstract::The time of re-evaluation of the role of human immunodeficiency viruses in the pathogenesis of acquired immune deficiency syndrome has now come, now that methods are available for the direct detection of human immunodeficiency viruses and for the detection of cellular anti-human immunodeficiency virus immune reactions...

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    pub_type: 杂志文章

    doi:10.1016/s0306-9877(96)90192-9

    authors: Hässig A,Wen-Xi L,Stampfli K

    更新日期:1996-04-01 00:00:00

  • Thiol oxidation of mitochondrial F0-c subunits: a way to switch off antimicrobial drug targets of the mitochondrial ATP synthase.

    abstract::A primary goal in antimicrobial drug design is to find molecules which inhibit key proteins in bacteria without affecting mammalian homologues. To this aim, structural differences between eukaryotic and prokaryotic enzyme proteins involved in life processes are widely exploited. The membrane-bound enzyme complex ATP s...

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    pub_type: 杂志文章

    doi:10.1016/j.mehy.2014.05.004

    authors: Nesci S,Ventrella V,Trombetti F,Pirini M,Pagliarani A

    更新日期:2014-08-01 00:00:00

  • Polymorphisms of sorbitol dehydrogenase (SDH) gene and susceptibility to diabetic retinopathy.

    abstract::The polyol pathway consists of two enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH); the former is the first enzyme in the polyol pathway, that catalyzes the reduction of glucose to sorbitol, the latter is the second one, that converts sorbitol to fructose using by NAD(+) as a cofactor. We along with oth...

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    pub_type: 杂志文章

    doi:10.1016/s0306-9877(03)00013-6

    authors: Amano S,Yamagishi S,Koda Y,Tsuneoka M,Soejima M,Okamoto T,Inagaki Y,Yamada K,Kimura H

    更新日期:2003-04-01 00:00:00

  • Magnesium for treatment-resistant depression: a review and hypothesis.

    abstract::Sixty percent of cases of clinical depression are considered to be treatment-resistant depression (TRD). Magnesium-deficiency causes N-methyl-d-aspartate (NMDA) coupled calcium channels to be biased towards opening, causing neuronal injury and neurological dysfunction, which may appear to humans as major depression. O...

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    pub_type: 杂志文章,评审

    doi:10.1016/j.mehy.2009.10.051

    authors: Eby GA 3rd,Eby KL

    更新日期:2010-04-01 00:00:00

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    abstract::The available epidemiological data for amyotrophic lateral sclerosis (ALS) support an infectious etiology and lead us to propose a new hypothesis. We examined older epidemiological data concerning categories of the population with increased incidence (aged people, people living in rural areas, farmers, breeders), more...

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    更新日期:2006-01-01 00:00:00

  • Early-life inflammation pathways trigger a cascade leading to development of atherosclerotic plaque through the "butterfly effect" - An hypothesis.

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    doi:10.1016/j.mehy.2018.10.026

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    更新日期:2019-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1016/j.mehy.2011.04.023

    authors: Spalice A,Del Balzo F,Papetti L,Nicita F,Ursitti F,Salvatori G,Iannetti P

    更新日期:2011-08-01 00:00:00

  • Postencephalitic Parkinson's disease, amyotrophic lateral sclerosis on Guam and influenza revisited: focusing on neurofibrillary tangles and the trail of tau.

    abstract::Circumstantial evidence links neuropathological changes in postencephalitic Parkinson's disease and amyotrophic lateral sclerosis on Guam to the 1918 influenza pandemic. Postencephalitic Parkinson's disease and amyotrophic lateral sclerosis have neuronal neurofibrillary tangles that anatomically correlate with clinica...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.2000.1224

    authors: Maurizi CP

    更新日期:2002-03-01 00:00:00

  • In restless legs syndrome, the neural substrates of the sensorimotor symptoms are also normally involved in upright standing posture and biped walking.

    abstract::Restless legs syndrome (RLS) exhibits sensorimotor symptoms. In familial cases, a gene at chromosomal location 9p-24-22 is linked to RLS and the expressed mutation is Dopamine Receptor Specific Individual Sensitivity (DRSIS). The symptoms are triggered during changes in alertness, generally at sleep hours, resulting f...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2009.02.028

    authors: Akpinar S

    更新日期:2009-08-01 00:00:00

  • Perfluorocarbon as an adjuvant for tumor anti-angiogenic therapy: Relevance to hypoxia and HIF-1.

    abstract::Lack of vascularization results in increased demand for oxygen and creates a defined feature of the tumor microenvironment known as tumor hypoxia. It is well established that in response to hypoxia, hypoxia-inducible factor-1 α (HIF-1α) is induced which is an important factor in angiogenesis, invasion and metastasis. ...

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    pub_type: 杂志文章

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    authors: Farhadi P,Yarani R,Kiani S,Mansouri K

    更新日期:2021-01-01 00:00:00

  • Parkinson disease classification using one against all based data sampling with the acoustic features from the speech signals.

    abstract::Parkinson's disease (PD) is a long-term degenerative disease that primarily affects the motor system of the central nervous system. This disease is difficult to diagnose and is one of the common diseases in the public. In this paper, we have proposed a novel data sampling method for the classification of Parkinson dis...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.109678

    authors: Polat K,Nour M

    更新日期:2020-03-16 00:00:00

  • A new proposed mechanism of action for gastric bypass surgery: Air hypothesis.

    abstract::Roux-en-Y gastric bypass (RYGB) surgery is one of the most effective treatments for obesity and type II diabetes. RYGB was originally believed to work by mechanically restricting caloric intake or causing macronutrient malabsorption. However, such mechanical effects play no role in the remarkable efficacy of gastric b...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2017.08.012

    authors: Celiker H

    更新日期:2017-09-01 00:00:00

  • External cardiac compression may be harmful in some scenarios of pulseless electrical activity.

    abstract::Pulseless electrical activity occurs when organised or semi-organised electrical activity of the heart persists but the product of systemic vascular resistance and the increase in systemic arterial flow generated by the ejection of the left venticular stroke volume is not sufficient to produce a clinically detectable ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2012.06.018

    authors: Hogan TS

    更新日期:2012-10-01 00:00:00

  • Impact of melanin on choroidal measurements.

    abstract::The thickness of the choroid is measured on the optical coherence tomography (OCT) as the distance between the hyperreflective retinal pigment epithelium and the hyperreflective chorio-scleral junction, contributed by the choroidal vessels and choroidal melanocytes. Our hypothesis is that the amount of absorption and ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.110408

    authors: Venkatesh R,Reddy NG,Chhablani J

    更新日期:2021-01-01 00:00:00

  • The enteric toxicity of gluten enhances graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.

    abstract::Pro-inflammatory peptides present in wheat and related grains are associated with celiac disease and non-celiac gluten sensitivity. We hypothesize that these peptides induce enteric responses that may exacerbate the gastrointestinal manifestations of graft-versus-host disease after an allogeneic hematopoietic stem cel...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2017.05.037

    authors: Neuman T,David K,Cooper D,Strair R

    更新日期:2017-07-01 00:00:00

  • Detection of hepatitis B virus transcriptional activity: an hypothesis.

    abstract::This paper outlines a method of demonstrating hepatitis B virus (HBV)-related transcriptional activity based on the random amplification of cDNA ends (RACE) protocol. Following RNA extraction from the appropriate tissue, cDNA is synthesized using a long oligo d(T) based primer containing unique 5' oligonucleotide sequ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(95)90056-x

    authors: Sallie R

    更新日期:1995-08-01 00:00:00

  • Speculations on vitamin K, VKORC1 genotype and autism.

    abstract::Humans vary in the gene that encodes for Vitamin K epoxide reductase complex (VKORC1). Recent research has documented the protective effect of Vitamin K on neural cells and its role in maintaining normal neural development. Of interest, specific neural effects of Vitamin K overlap with key brain development aberration...

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    pub_type: 杂志文章

    doi:10.1016/j.mehy.2016.09.013

    authors: DeSoto MC

    更新日期:2016-11-01 00:00:00

  • Long-term oral vancomycin for refractory inflammatory bowel diseases without Clostridium difficile infection: Lessons from primary sclerosing cholangitis.

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    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.110211

    authors: Du W,Han W,Dong J

    更新日期:2020-11-01 00:00:00

  • Skin: a promising reservoir for adult stem cell populations.

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    pub_type: 杂志文章

    doi:10.1016/j.mehy.2003.12.022

    authors: Chunmeng S,Tianmin C

    更新日期:2004-01-01 00:00:00

  • The influence of EDTA salts plus multivitamin-trace mineral therapy upon total serum cholesterol/high-density lipoprotein cholesterol.

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    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(82)90057-3

    authors: McDonagh EW,Rudolph CJ,Cheraskin E

    更新日期:1982-12-01 00:00:00