Abstract：
:The constant level of various proteins including albumin and cellular components in intravascular pool in vivo is strictly controlled by an unknown homeostatic mechanism, although there are fluctuations seen in pathologic conditions. Because the majority of the IgG in the serum is regarded as self-reactive natural autoantibodies, IgG may have a role to react with all proteins in vivo. It is hypothesized that like an immune system, a homeostatic mechanism for the protein pool also has a sensitive role to identify and memorize the extent and repertoire of both normal and pathogenic proteins on an individual basis, and IgG may be one of the major players in performing these functions. This hypothesis may explain the unresolved clinical observations as followed: (1) the marked increased IgG levels observed in self-limiting diseases presumed to come from immunological insults such as acute poststreptococcal glomerulonephritis and Kikuchi-Fujimoto disease, (2) an immediate reduction of all protein levels except immunoglobulins after intravenous immunoglobulin (IVIG) treatment in Kawasaki disease, (3) a unified explanation for the variety of immunomodulating effects exerted by IVIG, (4) the IgG-enzyme complexes observed in benign conditions such as macroamylasemia and hyperphosphatasemia, and (5) the marked decreased IgG level, which is correlated with the albumin level in minimal change nephrotic syndrome. IgG may be a 'watch-dog' for the disturbances of protein homeostasis in vivo. IgG may control the pathogenic proteins that appeared in disordered states, and it may help prevent the loss of proteins in case of nephrotic syndrome.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Lee KY,Lee JSdoi
10.1016/j.mehy.2006.04.011subject
Has Abstractpub_date
2006-01-01 00:00:00pages
848-55issue
4eissn
0306-9877issn
1532-2777pii
S0306-9877(06)00269-6journal_volume
67pub_type
杂志文章abstract：:Both human cell lines HL-60 and AML-193 exhibit a myeloblastic and promyelocytic morphology, respectively, but may be regarded as bipotent leukemic precursors. They can be triggered to differentiate to either granulocytes or monocytes upon retinoic acid (RA) or 1,25-dihydroxyvitamin D (D3) addition, respectively. We h...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(98)90025-1
更新日期：1998-03-01 00:00:00
abstract：:From biographical data sources on ranking scientists, I was able to identify 35 centenarians. Among these, only one (Michel Chevereul from France) lived before the 20th century. Since the remaining 34 individuals became centenarians only from 1965, I propose that centenarian scientists are an unusual cluster, first fo...
journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
doi：10.1054/mehy.2001.1480
更新日期：2001-12-01 00:00:00
abstract：:A wealth of research data points to increased oxidative stress as a key driver of the cardiac remodeling triggered by chronic pressure overload, loss of functional myocardial tissue, or atrial fibrillation. Oxidative stress is a mediator of the cardiomyocyte hypertrophy and apoptosis, the cardiac fibrosis, and the def...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2009.12.025
更新日期：2010-08-01 00:00:00
abstract：:Rheumatoid arthritis is complex and not clear on the mechanism of pathogenesis. On the basis of analysis of the symptom and pathology of rheumatoid arthritis patients, we raised a new hypothesis. The content of the hypothesis is as follows: (A) Collagen II or collagen II-Iike substance in human cartilage is the cross-...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00143-3
更新日期：2002-10-01 00:00:00
abstract：:The etiology of drug-induced agranulocytosis is poorly understood. Many drugs that induce neutropenia or agranulocytosis can be metabolized to reactive intermediates that covalently bind to macromolecules. Until now, the myeloid precursor cell or an earlier committed progenitor cell has been favoured as the target for...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1998.0734
更新日期：1999-08-01 00:00:00
abstract：:Acute stroke, including acute ischemic stroke (AIS) and acute hemorrhagic stroke, (AHS) is a common medical problem with particular relevance to the demographic changes in industrialized societies. In recent years, treatments for AIS have emerged, including thrombolysis with tissue plasminogen activator (t-PA). Althou...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.07.038
更新日期：2010-12-01 00:00:00
abstract：:The incidence of breast cancer in women has increased dramatically over the last decade. Epidemiological markers of this increased incidence include: endocrine related phenomena (early menarche, age of first parity and age of menopause); exposure of the breast to X-radiation; and a group of seemingly disparate factors...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(92)90090-y
更新日期：1992-07-01 00:00:00
abstract：:The contribution of various modes of transmission of SARS-CoV-2 has been the subject of recent intensive debate. The predominant route of the viral transmission is via exhaled droplets of different sizes which can be inhaled by nearby exposed individuals or deposited on peoples and surfaces. Touching contaminated surf...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110261
更新日期：2020-11-01 00:00:00
abstract：:Neuronal degeneration in the post-menopausal term leads to cognitive symptoms such as anxiety, difficulty in concentrating, overreacting to minor upsets, quickly becoming irritated and forgetfulness in approximately 70-80% of all women around the world. These symptoms, which result from microtubule damage in the axon ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.06.013
更新日期：2013-09-01 00:00:00
abstract：:In a survey based on the biographical sketches, obituary notes and eulogies of notable scientists, eight were identified as belonging to an elite group, having authored more than 1000 research publications, which include books, monographs and patents. They were, in chronological order, Thomas Alva Edison, Paul Karrer,...
journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
doi：10.1016/0306-9877(92)90179-g
更新日期：1992-10-01 00:00:00
abstract：:A novel substance-attributed biophysical theory of brain-mind unity is presented. We separate spiritualism and matters of the soul from the medical sphere. Biophysical principles are responsible for the body's operational regimen (BOR) in the homeostatic state which allows for materialization and emergence of the mind...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.0852
更新日期：2000-03-01 00:00:00
abstract：:The DSM is not brain-related and is thus unable to relate clinical assessments to putative brain disturbances. 'Clinical brain profiling' (CBP) involves the rearrangement of clinical findings to assess the relevant disturbances in brain dynamics. CBP has three major pathological dimensions, (1) disorders of basic brai...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.02.039
更新日期：2009-08-01 00:00:00
abstract：:The polyol pathway consists of two enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH); the former is the first enzyme in the polyol pathway, that catalyzes the reduction of glucose to sorbitol, the latter is the second one, that converts sorbitol to fructose using by NAD(+) as a cofactor. We along with oth...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00013-6
更新日期：2003-04-01 00:00:00
abstract：:We describe a new term: glutamate-based depression (GBD). GBD is defined as a chronic depressive illness associated with environmental stress and diseases associated with altered glutamate neurotransmission. We hypothesize that glutamate-induced over-activation of extrasynaptic NMDA receptors in the subgenual cingulat...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.02.009
更新日期：2012-05-01 00:00:00
abstract：:Both epidemiological and experimental studies have shown that impaired growth in utero due to maternal malnutrition, resulting in low birth weight, is associated with a high incidence of glucose intolerance, insulin resistance, and type 2 diabetes in adult life. Maternal malnutrition is a worldwide problem and unavoid...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.12.024
更新日期：2006-01-01 00:00:00
abstract：:The presence of the tumour induces important metabolic changes in the cancer patient which are not merely due to the fact that the tumour acts as a parasite, thus depleting the host of nutrients, but that are mainly the result of both tumoral and humoral mediators. The new metabolic status of the cancer patient may le...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(98)90037-8
更新日期：1998-11-01 00:00:00
abstract：:Recently, the concept of drug delivery requires that the release of encapsulated drug be produced only at the diseased site with controllable rates. Given that thermosensitive hydrogels have been widely investigated for controlled delivery based on their phase transition, we speculate that nanoparticles with the novel...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.03.023
更新日期：2008-08-01 00:00:00
abstract：:Metformin, a drug widely used in the treatment of type II diabetes mellitus (T2DM), has been the focus of interest as a potential therapeutic agent for certain types of malignancies, including gynaecological cancers [i.e. endometrial cancer (EC)]. Although the exact mechanism behind the potential anticancer activity o...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109420
更新日期：2020-01-01 00:00:00
abstract：:The etiology of intra-abdominal adhesions is explained by hydrolysis of the peritoneal phospholipid layer caused by phospholipase A2 activity. This view could unify the pre-existing hypotheses that intra-abdominal adhesions are due to ischemia or increased plasminogen activator activity. New therapeutic approaches are...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(93)90109-4
更新日期：1993-12-01 00:00:00
abstract：:Currently, drug repurposing is an alternative to novel drug development for the treatment of COVID-19 patients. The antimalarial drug chloroquine (CQ) and its metabolite hydroxychloroquine (HCQ) are currently being tested in several clinical studies as potential candidates to limit SARS-CoV-2-mediated morbidity and mo...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109815
更新日期：2020-09-01 00:00:00
abstract：HYPOTHESIS:The delayed lung damage after SARS-CoV-2 infection may be caused by an autoimmune response to ACE2 induced by forced presentation of the ACE2 protein in a complex with CoV Spike in Fc Receptor positive Antigen Presenting Cells in the lung. The likelihood that this hypothesis is valid is low, but it is easily...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110043
更新日期：2020-11-01 00:00:00
abstract：:No survival profit has been achieved for patients with disseminated prostate cancer since hormonal therapy was introduced. It is proposed that dissemination of rare prostatic cancer stem cells may lead to metastatic disease and that resistance of these cells to androgen ablation makes them responsible for failure of c...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.06.021
更新日期：2008-11-01 00:00:00
abstract：:There are different theories and hypotheses related to the aetiology of depression. The interaction between brain 5-HT level and the activity of its autoreceptors plays a role in mood changes and depression. In major depression, activation of the inflammatory response system (IRS) and, increased concentrations of proi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00207-x
更新日期：2003-11-01 00:00:00
abstract：:This novel, iso-osmo-resistive theory offers electro-resistivity of food components as a new dimension for digestion. Firstly, fats, carbohydrates and proteins differ markedly in their resistivity, which offers a way to monitor them, especially when digestive enzymes cause consistent and distinctive changes. Secondly ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109282
更新日期：2019-09-01 00:00:00
abstract：:The exact contribution of the sirtuin family of NAD+-dependent histone deacetylases to longevity in metazoans is, at present, not completely understood but nonetheless regarded as significant. Despite the rapidly accreting evidence solidifying the role of NAD+-dependent histone deacetylase activity in longevity-promot...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.08.032
更新日期：2006-01-01 00:00:00
abstract：:Logic, a fundamental component of research in the exact sciences is often not applied in prominent fields of medical research. Investigation into the aetiopathogenesis of headache, vertigo, and fatigue--acknowledged as the commonest and amongst the most prominent and debilitating of symptoms known to mankind--may be s...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(90)90025-a
更新日期：1990-04-01 00:00:00
abstract：:In this work a new theory of acoustic signal detection in the inner ear and an experimental explanation of the causes of bifilar cochlear structure was presented. Our innovative approach describes sound detection in a completely different way from the one currently adopted. It requires analyzing the inner ear system i...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109636
更新日期：2020-02-18 00:00:00
abstract：:It is proposed that gastrin promotes the uptake of divalent and trivalent metal ions from the gastrointestinal lumen by catalyzing the binding of metal ions to luminal albumin and transferrin respectively. The following observations are consistent with this hypothesis: 1. Gastrin binds both divalent and trivalent meta...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(92)90161-5
更新日期：1992-05-01 00:00:00
abstract：:It was hypothesized decades ago that reduced levels of brain monoamines such as serotonin or norepinephrine form, at least in part, a pathophysiological basis for major depression. Consistent with this hypothesis, a conventional strategy used, with varying success, to treat major depression involves administering anti...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.03.023
更新日期：2013-06-01 00:00:00
abstract：:Obesity is a major risk-factor for the development of insulin resistance, type 2 diabetes, and cardiovascular disease. Circulating molecules associated with obesity, such as saturated fatty acids and cholesterol crystals, stimulate the innate immune system to incite a chronic inflammatory state. Studies in mouse model...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.04.039
更新日期：2016-07-01 00:00:00
