当前位置： SCI文献检索 > MEDICAL HYPOTHESES期刊下所有文献 > The role of aromatic hydrocarbons in the genesis of breast cancer.

The role of aromatic hydrocarbons in the genesis of breast cancer.

Abstract：

:The incidence of breast cancer in women has increased dramatically over the last decade. Epidemiological markers of this increased incidence include: endocrine related phenomena (early menarche, age of first parity and age of menopause); exposure of the breast to X-radiation; and a group of seemingly disparate factors--urban residence, dietary selection and alcohol consumption. Although experimental breast cancer may be induced by estrogenic hormones, X-radiation and aromatic hydrocarbons, only aromatic hydrocarbons have not been previously implicated in human mammary carcinogenesis. The seemingly unrelated human factors can best be understood by examining the role of breast tissue in aromatic hydrocarbon metabolism. Aromatic hydrocarbons are important environmental chemicals produced by the incomplete combustion of hydrocarbons for use in energy production. Benzene, benz(a)pyrene, dibenz(ah)anthracene and 1-nitropyrene, known experimental breast carcinogens, are produced in this way. Human exposure to aromatic hydrocarbon metabolites induces and promotes altered DNA by mechanisms described as increased intracellular pro-oxidant production as well as direct adduction to DNA. The breast is anatomically embedded in a major fat depot which stores and concentrates aromatic hydrocarbons and can metabolize these hydrocarbons to carcinogenic metabolites. Ductal cells concentrate these metabolites and themselves become target cells for carcinogenesis. Some lifestyle factors increase the amount of carcinogens produced or enhance their activity. A unitary model for mammary carcinogenesis in humans as well as in experimental carcinogenesis is hypothesized. If correct, the hypothesis would account for some of the increase in breast cancer incidence in industrial countries--and would suggest environmental and dietary modifications that would inhibit hydrocarbon induced mammary carcinogenesis.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Morris JJ,Seifter E

doi

10.1016/0306-9877(92)90090-y

keywords:

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

177-84

issue

3

eissn

0306-9877

issn

1532-2777

pii

0306-9877(92)90090-Y

journal_volume

38

pub_type

杂志文章

相关文献

MEDICAL HYPOTHESES文献大全
  • Secondary to excessive melatonin synthesis, the consumption of tryptophan from outside the blood-brain barrier and melatonin over-signaling in the pars tuberalis may be central to the pathophysiology of winter depression.

    abstract：:Seasonal affective disorder is defined as recurrent episodes of major depression, mania, or hypomania with seasonal onset and remission. In this class of mood disturbances, a unipolar major depressive disorder known as winter depression is common in populations living in northern latitudes far from the equator. Winter...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2016.11.020

    authors： Pereira JC Jr,Pradella Hallinan M,Alves RC

    更新日期：2017-01-01 00:00:00

  • A model for metal selenide formation under biological conditions.

    abstract：:The essential trace element selenium is known to be capable of reducing the toxicity of heavy metals like cadmium(II), mercury(II) and silver(I). One mechanism by which this occurs is through the formation of an inert metal selenide like silver selenide. It is not clear why selenide should react in the body preferenti...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/0306-9877(87)90107-1

    authors： Nuttall KL

    更新日期：1987-10-01 00:00:00

  • Using histamine (H1) antagonists, in particular atypical antipsychotics, to treat anemia of chronic disease via interleukin-6 suppression.

    abstract：:Anemia of chronic disease (ACD) is a condition of decreased red cell mass secondary to some other chronic inflammatory condition. In ACD total body iron stores are normal, though serum iron is typically low secondary to iron sequestration by macrophages, and often iron supplementation is not an effective treatment for...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2005.01.036

    authors： Altschuler EL,Kast RE

    更新日期：2005-01-01 00:00:00

  • Tracing the origins of "fetal origins" of adult diseases: programming by oxidative stress?

    abstract：:Too small size at birth (due to poor fetal growth and/or preterm delivery) has been associated with substantially elevated risks of the metabolic syndrome (dislipidemia, insulin resistance, hypertension), type 2 diabetes and cardiovascular disease in adulthood. The mechanisms of such "fetal origins" or "programming" o...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2005.08.020

    authors： Luo ZC,Fraser WD,Julien P,Deal CL,Audibert F,Smith GN,Xiong X,Walker M

    更新日期：2006-01-01 00:00:00

  • Has enhanced folate status during pregnancy altered natural selection and possibly Autism prevalence? A closer look at a possible link.

    abstract：:The inverse association between maternal folate status and incidence of infants born with neural tube defects (NTD's) was recognized over twenty years ago and led the US health agencies in the early 1990s to recommend that women of childbearing age consume 400 microg of folic acid each day. The FDA followed by mandati...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2008.04.013

    authors： Rogers EJ

    更新日期：2008-09-01 00:00:00

  • Why does chloroquine impair renal function?: chloroquine may modulate the renal tubular response to vasopressin either directly by inhibiting cyclic AMP generation, or indirectly via nitric oxide.

    abstract：:Chloroquine is one of the antimalaria drugs, also used to treat rheumatoid arthritis and systemic lupus erythematosus (SLE). Although well tolerated in most individuals, it was suggested that chloroquine can exert a profound influence on renal function, especially in individuals with compromised body fluid status. How...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2006.06.012

    authors： Ahmed MH,Osman MM

    更新日期：2007-01-01 00:00:00

  • Host melatonin secretion is a timing signal for the release of W. bancrofti microfilaria into the circulation.

    abstract：:Infection of the lymphatic system by Wuchereria bancrofti microfilaria is the most common cause of elephantiasis, a disease that affects over 100 million people. The nightly release of microfilaria into the circulation coincides with the feeding activity of its mosquito vector, a synchronization that is presumably an ...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2009.02.034

    authors： Sack RL

    更新日期：2009-08-01 00:00:00

  • Embryogenesis, morphogens and cancer stem cells: putting the puzzle together.

    abstract：:This paper describes a model which puts together three key elements of cancer theory: the analogies between embryogenesis and carcinogenesis, the role played in both processes by morphogens and related pathways, and the recently emerged paradigm of cancer stem cells. The model is called Epigenetic Tracking. Originally...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2013.07.021

    authors： Fontana A,Wróbel B

    更新日期：2013-10-01 00:00:00

  • Pressure waves in neurons and their relationship to tangled neurons and plaques.

    abstract：:The paper based on the hypothesis that mechanical impulses cause the transmission of excitement in the peripheral and central nervous system. Possible connections between changes in the tubular neuronal network and the morphological findings of Alzheimer's disease are presented. Additionally, changes in the viscosity ...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2014.02.012

    authors： Barz H,Barz U

    更新日期：2014-05-01 00:00:00

  • AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome.

    abstract：:The endotheliopathy associated with insulin resistance syndrome appears to result largely from excessive free fatty acid (FFA) exposure that boosts endothelial production of diacylglycerol, thereby activating protein kinase C. This endothelial "lipotoxicity" can be alleviated by very-low-fat diets and by appropriate w...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2004.01.042

    authors： McCarty MF

    更新日期：2005-01-01 00:00:00

  • M2-like cells from the macrophage lineage might play a central role in closure of the embryonic neural tube.

    abstract：:Herein it is hypothesized that M2-like macrophages or pre-macrophages of fetal origin might play a central role in development and closure of the neural tube. Early in embryonic development, pre-macrophages arise from the fetal yolk sac and track through the bloodstream to reach diverse embryonic tissues, where they m...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2019.109264

    authors： Block J

    更新日期：2019-08-01 00:00:00

  • Some thoughts on the epidemiology of cardiovascular disease, (with special reference to women "on the pill"). Role of ascorbic acid.

    abstract：:Consideration of nine major factors predisposing to cerebral thrombosis, coronary thrombosis or thrombosis in the deep veins of the calf, reveals that these factors all have one thing in common. Estrogen administration, pregnancy, ageing, smoking, infection, trauma, surgery, soft water and winter season are all associ...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/0306-9877(79)90072-0

    authors： Clemetson CA

    更新日期：1979-08-01 00:00:00

  • The role of dietary ergothioneine in the development of diabetes mellitus.

    abstract：:Ergothioneine is believed not to be synthesized by man but it accumulates to high concentrations in some mammalian cells as a result of dietary intake. Ergothioneine is known to chelate divalent metal ions with high affinity. Other substances which are potent chelators of divalent metal ions such as diphenylthiocarbaz...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/0306-9877(82)90137-2

    authors： Epand RM

    更新日期：1982-08-01 00:00:00

  • mTOR inhibitors for treatment of low-risk prostate cancer.

    abstract：:Prostate cancer incidence increases with age; along with many other cancers, it could be considered a disease of aging. Prostate cancer screening has led to a significant proportion of men diagnosed with low-grade, low-stage prostate cancer who are now more likely to choose an active surveillance strategy rather than ...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2018.06.004

    authors： Liss MA,Rickborn L,DiGiovanni J,Bacich D,DeGraffenried LA,Parihar M,Thompson IM,Sharp ZD

    更新日期：2018-08-01 00:00:00

  • Intermittent hypoxia as a means to improve aerobic capacity in type 2 diabetes.

    abstract：:Physical inactivity and a low maximal aerobic capacity (VO2max) strongly predict morbidity and mortality in patients with type 2 diabetes (T2D). Patients with T2D have a reduced VO2max when compared with healthy individuals of similar age, weight, and physical activity levels, and this lower aerobic capacity is usuall...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2017.01.010

    authors： Leone RJ,Lalande S

    更新日期：2017-03-01 00:00:00

  • Volume transmission as a mechanism of time-dependent sensitization to antidepressant therapy.

    abstract：:Administration of certain drugs such as antidepressants have been shown to produce a phenomenon known as time-dependent sensitization, a process in which the acute effects of the drugs sensitize and grow over time. While both preclinical and clinical studies have demonstrated time-dependent sensitization, it is still ...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1054/mehy.1999.1001

    authors： Nathan P

    更新日期：2000-06-01 00:00:00

  • Amplification of extracellular nucleotide-induced leukocyte(s) degranulation by contingent autocrine and paracrine mode of leukotriene-mediated chemokine receptor activation.

    abstract：:Extracellular nucleotide-induced stimulation and activation of peripheral blood leukocytes and subsequent degranulation play a critical role in immediate-type hypersensitivity reaction and other inflammatory diseases. The extracellular nucleotides stimulate a P2Y receptor(s) on human PMN with the pharmacological profi...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/s0306-9877(02)00213-x

    authors： Kannan S

    更新日期：2002-09-01 00:00:00

  • Influenza H1N1 and the world wide economic crisis--a model of coherence?

    abstract：:A recent published model described the phenomenon of a global panic reaction (GPR) on the stock markets based on two remarkable stock market crashes in the months of January and March [Sperling W, Bleich S, Reulbach U, Black Monday on stock markets throughout the world - a new phenomenon of collective panic disorder? ...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2009.05.011

    authors： Sperling W,Biermann T

    更新日期：2009-11-01 00:00:00

  • Inflammatory cytokines as an underlying mechanism of the comorbidity between bipolar disorder and migraine.

    abstract：:A bi-directional association between mood disorders and migraine has been consistently reported. Nevertheless, the neurobiological substrate underlying the association between these disorders remains unknown. In the article herein we review evidence for the role of inflammatory cytokines in the neurobiology of bipolar...

    journal_title：Medical hypotheses

    pub_type： 杂志文章,评审

    doi：10.1016/j.mehy.2012.01.036

    authors： Brietzke E,Mansur RB,Grassi-Oliveira R,Soczynska JK,McIntyre RS

    更新日期：2012-05-01 00:00:00

  • Could cells from menstrual blood be a new source for cell-based therapies?

    abstract：:Human endometrium is a highly regenerative tissue and contains a low number of cells which have high replicative ability and differentiation efficiency. This has been identified by many scientists. When the fresh growth of tissue and blood vessels is shed during each menstrual cycle, some cells with regenerative capab...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2008.10.021

    authors： Zhang MJ,Liu B,Xia W,Sun ZY,Lu KH

    更新日期：2009-03-01 00:00:00

  • Etiology of antisocial personality disorder: benefits for society from an evolutionary standpoint.

    abstract：:As human society is mainly cooperative, it is not clear how antisocial personality disorder (APD) persists. The current explanation is that sociopaths are cheaters who maximize their fitness by taking advantages from others. Although this argument is valid, we show here that society also benefits from APD. We propose ...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2005.05.027

    authors： Miric D,Hallet-Mathieu AM,Amar G

    更新日期：2005-01-01 00:00:00

  • Is olfactory detection of human cancer by dogs based on major histocompatibility complex-dependent odour components?--A possible cure and a precocious diagnosis of cancer.

    abstract：:Given the reports made about dogs detecting cancer on the basis of odour, our hypothesis is that the volatile organic compounds produced by tumours, and detected by dogs, are products of MHC genes. Two lines of evidences support this hypothesis: (1) human body odour is genetically determined by MHC. These antigen mole...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2005.08.027

    authors： Balseiro SC,Correia HR

    更新日期：2006-01-01 00:00:00

  • Construction of a bispecific antisense oligonucleotide containing multiple binding sites for the treatment of hormone insensitive prostate tumors.

    abstract：:Antisense oligonucleotides (oligos) have demonstrated efficacy for the treatment of various cancers, infectious diseases and metabolic disorders. While most studies have utilized single oligos either administered alone, or more recently in combination therapy with other drugs, some investigators have administered more...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2004.12.032

    authors： Rubenstein M,Tsui P,Guinan P

    更新日期：2005-01-01 00:00:00

  • Foetal origins of adult diseases: just a matter of stem cell number?

    abstract：:Intrauterine growth retardation (IUGR) is associated with insulin resistance, non-insulin-dependent diabetes mellitus (NIDDM) and cardiovascular diseases in adulthood. Postnatal tissues contain stem cells that though quiescent, retain their capacity to self-renew and regenerate tissues to fulfil organ demands. I propo...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/s0306-9877(03)00182-8

    authors： Cianfarani S

    更新日期：2003-09-01 00:00:00

  • Fortress brain.

    abstract：:Neurodegenerative diseases are associated with neuronal inclusions, comprised of protein aggregates. In Alzheimer's Disease (AD) and Lewy Body Disease (LBD) such lesions are distributed in a hierarchical retrograde transynaptic spatial pattern. This implies a retrograde transynaptic temporal propagation as well. There...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2012.11.005

    authors： Royall DR

    更新日期：2013-02-01 00:00:00

  • Testosterone therapy, thrombophilia, and hospitalization for deep venous thrombosis-pulmonary embolus, an exploratory, hypothesis-generating study.

    abstract：:Our hypothesis was that testosterone therapy (TT) interacts with previously undiagnosed thrombophilia-hypofibrinolysis, leading to hospitalization for deep venous thrombosis (DVT)-pulmonary emboli (PE). We determined the prevalence of DVT-PE associated with TT 147 men hospitalized in the last 12 months for DVT-PE. Of ...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2015.01.020

    authors： Glueck CJ,Friedman J,Hafeez A,Hassan A,Wang P

    更新日期：2015-04-01 00:00:00

  • Anesthesia is a risk factor for drug and alcohol craving and relapse in ex-abusers.

    abstract：:Relapse to cocaine, heroin, and alcohol is a common occurrence in ex-abusers of these substances. Although there are many potential causes for relapse, we postulate that one cause in some people may be re-exposure in an anesthesia setting to a drug similar to the formerly abused drug. We hypothesize, for example, that...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1054/mehy.1999.0797

    authors： Sadeghi P,Zacny JP

    更新日期：1999-12-01 00:00:00

  • Are B lymphocytes involved in allograft/tumor rejection and GVH?

    abstract：:Several earlier observations by us and other investigators led us to propose a thesis that B lymphocytes, when activated by a virus, allo-antigen or bacterial protein would enter into effector arm of the immune response and cause allograft and tumor rejection or GVH-type of lesion in immunosuppressed animals. These ef...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/0306-9877(90)90071-l

    authors： Krishnan G

    更新日期：1990-05-01 00:00:00

  • Understanding pluripotency under folic acid deficiency using embryonic stem cells as an in vitro model.

    abstract：:Innumerable studies have been carried out by people to trace out those elements, find out the mechanisms that are vital to the maintenance of stemness. Amongst them, the one which is gaining importance in the recent past is the metabolism of stem cells, especially One carbon metabolism. Being associated directly or in...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2017.12.019

    authors： Kasulanati S,Venkatesan V

    更新日期：2018-02-01 00:00:00

  • The plateau iris component of primary angle closure glaucoma: developmental or acquired.

    abstract：:Primary angle closure glaucoma has been called the most common form of glaucoma in the world, and the leading cause of bilateral blindness. Pupillary block is felt to be the main mechanism of outflow obstruction in this condition. Recent advances in morphologic assessment of angle closure, specifically by means of ult...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2006.11.025

    authors： Razeghinejad MR,Kamali-Sarvestani E

    更新日期：2007-01-01 00:00:00